Clinical trials: Opioids
Healthy Volunteer, Opioid-use Disorder
Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use Disorder
The primary objectives for the study are: Part I and Part II: Assess safety and tolerability of repeated doses of INDV-2000 in healthy volunteers.
- Trial name
- NCT04976855
- Testing
- INDV-2000, SUBOXONE® sublingual film
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Opioid Use
Best Practice Alert for Opioid Prescribing
The investigators will embed a developed decision support tool into the electronic health record (EHR) to individualize pain therapy in surgical patients after hospital discharge and test its performance in a pragmatic clinical…
- Trial name
- NCT04446975
- Testing
- BPA
- Where
- United States
- Volunteers
- 21,689 people
- Sponsor
- University of Colorado, Denver
Chronic Pain, Suicidal Ideation
Mindfulness for Pain and Suicide
The proposed study will assess the feasibility and acceptability of a mindfulness-based intervention to reduce functional impairment from chronic pain and risk of suicide.
- Conditions
- Chronic Pain, Suicidal Ideation, Suicide, Attempted, Opioid Use
- Trial name
- NCT05286112
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Health Education
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Canandaigua VA Medical Center
Opioid-use Disorder
Evaluation of Doxazosin to Alter the Abuse of Oxycodone
Healthy, adult men and women, aged 21 to 59 years, who abuse opioids and are physically dependent on them will be recruited to participate in a study to examine the ability of doxazosin, an epinephrine receptor blocker, to alter…
- Trial name
- NCT03415581
- Testing
- Intranasal Oxycodone, Cue Session
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Opioid Use, Sedative Use
Prescription Medication Interactions
This study will examine the effects of doses of opioid/placebo and doses of sedative/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other…
- Trial name
- NCT04315181
- Testing
- Opioid Agonist, Sedatives
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Sharon Walsh
Depression, Acute Pain
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center)
This is a Master Protocol Screening record. This study is comprised of three separate pharmacogenetic trials grouped into a single protocol due to similarities in the intervention, the hypotheses, and the trial design.
- Conditions
- Depression, Acute Pain, Chronic Pain
- Trial name
- ADOPT PGx (NCT04445792)
- Testing
- Pharmacogenetic testing, Clinical decisions support
- Where
- 14 sites in United States
- Volunteers
- 4,284 people
- Sponsor
- Duke University
Arthropathy of Knee Joint
Opioid-free Accelerated Recovery Total Knee Arthroplasty
To prove that total knee arthroplasty can be performed with little, if any need for opioids by using a combination of patient education, optimized pre-op and post-op pain and recovery protocols.
- Trial name
- NCT03647709
- Testing
- opioids
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- St. Elizabeth Medical Center, Utica, NY
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Alcohol Use, Drug Use
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
This application is a competing continuation of a grant in which we developed and pilot tested a computerized Therapeutic Workplace designed to train and employ adults as data entry operators.
- Conditions
- Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
- Trial name
- NCT00249496
- Testing
- Contingency management, Employment Only
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Opioid Use Disorder, Severe, in Sustained Remission, Opioid Use Disorder, Severe, in Early Remission
KAP for Depression in Abstinent Opioid Users
The purpose of the study is to examine whether an investigational medication called ketamine along with psychotherapy is an effective treatment for depression in participants with a history of opioid addiction who have not abused…
- Conditions
- Opioid Use Disorder, Severe, in Sustained Remission, Opioid Use Disorder, Severe, in Early Remission, Major Depressive Disorder
- Trial name
- KReDO (NCT05193318)
- Testing
- Ketamine-assisted psychotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Opioid Cessation
Motivational Interviewing and Guided Opioid Tapering Support to Promote Postoperative Opioid Cessation
The purpose of this study is to evaluate the relative efficacy of enhanced usual care versus motivational interviewing and guided opioid tapering support to promote opioid cessation after total hip or knee replacement surgery.
- Trial name
- NCT03659734
- Testing
- Motivational Interviewing and Guided Opioid Tapering Support, Enhanced Usual Care
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Stanford University
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid-use Disorder, Opioid-Related Disorders
Substance Use Treatment and Recovery Team
This study is a multi-site, randomized pragmatic trial being conducted at three diverse sites. The study, called the Substance Use Treatment and Recovery Team (START), will evaluate whether a collaborative care team increases the…
- Trial name
- START (NCT05086796)
- Testing
- Substance Use Treatment and Recovery Team (START)
- Where
- 3 sites in United States
- Volunteers
- 325 people
- Sponsor
- Cedars-Sinai Medical Center
Knee Osteoarthritis, Pain, Postoperative
Acupuncture for Low-Dose Opioid for TKA Replacement
The majority of patients undergoing total knee replacement(TKR) rely on opioids for postoperative analgesia. These medications have undesirable side effects and potential for abuse and addiction.
- Conditions
- Knee Osteoarthritis, Pain, Postoperative, Acupuncture
- Trial name
- NCT04084288
- Testing
- Acupuncture, Peripheral Nerve Stimulator
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Hospital for Special Surgery, New York
Trauma Injury, Pain
Ketamine for Acute Pain Management After Trauma
The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.
- Conditions
- Trauma Injury, Pain, Opioid Use
- Trial name
- KAPT (NCT04129086)
- Testing
- Ketamine plus usual care, Usual Care
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
Lumbar Spine Degeneration
A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.
The purpose of this study is to establish a relationship between liposomal bupivacaine surgical site injection and postop opioid utilization.
- Trial name
- Exparel (NCT04644796)
- Testing
- saline 0.9%, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Missouri-Columbia
Post Operative Pain
Trial of Extended Release Bupivacaine for Pain Relief After Surgery
This is a research study of SABER® -Bupivacaine, an experimental medication designed to reduce pain for up to 3 days after surgery.
- Trial name
- PERSIST (NCT02574520)
- Testing
- SABER-Bupivacaine (Part 1), SABER-Bupivacaine (Part 2), Bupivacaine HCl
- Where
- 21 sites in United States
- Volunteers
- 399 people
- Sponsor
- Durect
Analgesics, Gabapentin
Pregabalin vs. Gabapentin on Reducing Opioid Usage
This is a single-center, randomized, open-label, Phase 4 clinical trial investigating the efficacy of multiple-dose administrations of Pregabalin or Gabapentin in combination with traditional opioid pain medications to decrease…
- Conditions
- Analgesics, Gabapentin, Injuries, Narcotics
- Trial name
- NCT04705480
- Testing
- Pregabalin 50mg, Gabapentin 300mg, Neither Pregabalin nor Gabapentin
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- CAMC Health System
Anesthesia, Opioid Use
PROUD Study - Preventing Opioid Use Disorders
The objective of this study is to pilot an opioid free anesthetic protocol for patients undergoing total hip replacement.
- Trial name
- NCT04766996
- Testing
- Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
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