Clinical trials: Opioids
Opioid-use Disorder
Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)
Through CTN-0076-Ot (Clinical Decision Support for Opioid Use Disorders in Medical Settings: Pilot Usability Testing in an EMR (COMPUTE)), our team has iteratively developed and piloted a web-based and electronic health record…
- Trial name
- NCT04198428
- Testing
- Opioid Wizard
- Where
- 3 sites in United States
- Volunteers
- 10,891 people
- Sponsor
- HealthPartners Institute
Dental Anxiety, Dental Pain
Nonpharmacologic Reduction of Periprocedural Distress and Drug Use
Objectives of this Phase I pilot trial are to provide data towards assessing and facilitating feasibility of a larger scale Phase II trial in which the effects of a calmative Comfort Talk® app can be unequivocally evaluated.
- Conditions
- Dental Anxiety, Dental Pain, Drug Use, Opioid Use
- Trial name
- NCT03328208
- Testing
- Comfort Talk® app, White Noise app
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Hypnalgesics, LLC
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Acute Pain
IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients
The goal of this randomized clinical trial is to compare the analgesic efficacy and side effect profile of IV acetaminophen as an analgesic adjunctive medication to IV hydromorphone for the treatment of acute pain experienced by…
- Trial name
- NCT03553498
- Testing
- IV acetaminophen, hydromorphone
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Albert Einstein College of Medicine
Pain, Anesthesia
Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia
To explore and compare antihyperalgesic effects of Dexmedetomidine,Nalmefene,and a combination of both received before anesthesia induction.
- Trial name
- NCT03096730
- Testing
- Normal saline, Remifentanil, Sufentanil
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tianjin Medical University General Hospital
Chronic Pain
Effect of Guanfacine on the Reversal of Opioid-induced Hyperalgesia (OIH)
Combination of guanfacine with opioid medication as a standard treatment for chronic pain.
- Trial name
- NCT02192398
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Opioid Use Disorder, Substance Use Disorder
Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction
Support groups are an important component of addiction treatment, where individuals at more stable stages of their recovery help others by sharing personal experiences.
- Conditions
- Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder
- Trial name
- NCT07344233
- Testing
- Real-time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pain, Osteoarthritis, Hip
Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
This clinical trial tests the pain relieving effectiveness of OROS hydromorphone, a once-daily formulation of a strong opioid against placebo in patients, who are suffering from pain due to osteoarthritis of the hip or the knee…
- Conditions
- Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT00980798
- Testing
- OROS hydromorphone HCl
- Where
- 12 sites in Czechia, Romania and 2 more
- Volunteers
- 288 people
- Sponsor
- Janssen-Cilag International NV
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Multiple Myeloma, Hodgkin Disease
Managing Pain and Symptom Burden Caused by Chemotherapy in People With Myeloma or Lymphoma
The purpose of this study is to find out whether acupuncture treatments can reduce the need for opioid medication when managing pain caused by chemotherapy.
- Conditions
- Multiple Myeloma, Hodgkin Disease, Non-Hodgkin Lymphoma
- Trial name
- NCT04459416
- Testing
- Acupuncture, opioid, Assessments
- Where
- 2 sites in United States
- Volunteers
- 299 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Opioid Misuse
A Digital Intervention to Prevent Initiation of Opioid Misuse in Adolescents in School-based Health Centers
This study's specific aims were to: develop a digital intervention as a prevention intervention through focus groups with 40 youth; pilot-test the developed digital intervention with 30 adolescents, using methods from the…
- Trial name
- NCT04109599
- Testing
- PlaySmart, PlaySmart Storyline, Play Smart Mini-Game
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
To Determine the Fasting Bioequivalence of Reformulated OXY Tablets and Original OxyContin® (OXY) Tablets
The purpose of this study is to assess the bioequivalence of a new oxycodone formulation (40 mg) relative to the original OxyContin® (OXY) formulation (40 mg) in the fasted state.
- Trial name
- NCT01101165
- Testing
- Reformulated OXY (oxycodone HCl), Original OxyContin® (OXY) (oxycodone HCl)
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Cocaine Dependence, Opioid Dependence
Pharmacogenetics of Disulfiram for Cocaine
Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment.
- Trial name
- Disulfiram (NCT00149630)
- Testing
- Disulfiram, Methadone, CBT
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Baylor College of Medicine
Pain, Postoperative, Amputation
Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations
Through this pilot prospective trial, we aim to obtain preliminary data investigating the effectiveness of perineural catheters and liposomal bupivacaine, both currently accepted as standard care at Maine Medical Center, for the…
- Trial name
- NCT05140499
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Aurora Quaye
Opioid Use Disorder, Medication Adherence
MHealth Incentivized Adherence Plus Patient Navigation
Polysubstance use involving opioids and methamphetamine is emerging as a new public health crisis. Patients with opioids and methamphetamine use often experience serious medical complications requiring hospitalization, which…
- Conditions
- Opioid Use Disorder, Medication Adherence, Polysubstance Drug Use (Indiscriminate Drug Use), Methamphetamine-dependence
- Trial name
- MIAPP (NCT06027814)
- Testing
- Patient Navigation and mHealth (PN+mHealth)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Chronic Pain
Pain Catastrophizing and Prescription Opioid Craving
Adherence to prescription opioid and opioid tapering as indicated are critical for safe chronic opioid therapy for chronic pain, but this can be difficult for patients experiencing prescription opioid craving.
- Trial name
- NCT04097743
- Testing
- Coping Statement
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Stanford University
Hepatitis C, Opiate Dependence
Effective Treatment of Hepatitis C in Substance Users
We hypothesize that integrating Hepatitis C into methadone and buprenorphine treatment will improve Hepatitis C outcomes as well as drug treatment outcomes in patients who are addicted to opiates.
- Trial name
- NCT00633243
- Testing
- Modified Directly Observed Therapy (mDOT), Self-Administered Therapy (SAT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Acute Low Back Pain
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
Low back pain causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In a general low back pain (LBP) population, prognosis is poor.
- Trial name
- NCT01587274
- Testing
- Naproxen, Cyclobenzaprine, Oxycodone/ acetaminophen
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Montefiore Medical Center
Opioid Use Disorder
Remote Methadone Ingestion Surveillance Trial (RMIST)
The Remote Methadone Ingestion Surveillance Trial (RMIST) will explore a potential method of methadone ingestion surveillance that may mitigate patient safety risks of take-home methadone treatment regimens while minimizing the…
- Trial name
- NCT05259501
- Testing
- RMIST
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Pain, Opioid-use Disorder
Imaging the Effects of rTMS on Chronic Pain
Chronic pain is highly prevalent in patients with opioid use disorder on methadone maintenance therapy, and associated with problems related to psychosocial functioning, medical and psychiatric health, and substance craving and…
- Trial name
- NCT02687360
- Testing
- Active rTMS treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- New York State Psychiatric Institute