Clinical trials: Optic Disk
Keratoconus, Glaucoma
Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus
The mechanism by which vision loss in glaucoma occurs is still unknown, but it is clear that increased Intraocular Pressure (IOP) is a major risk factor.
- Trial name
- NCT03560609
- Testing
- Ophthalmodynamometer, Goldmann applanation tonometer, Pentacam
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NYU Langone Health
Posterior Vitreous Detachment, Vitreomacular Traction
Vitreopapillary Interface and Optic Disc Morphology
The vitreous fills the posterior chamber of the eye and is firmly attached, at the posterior pole, to the macula and the optic nerve head (ONH).
- Conditions
- Posterior Vitreous Detachment, Vitreomacular Traction, Glaucoma, Vitreopapillary Traction
- Trial name
- NCT02290795
- Testing
- OCT imaging/HRT imaging
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
Optical Coherence Tomography (OCT) Normative Data Collection Study
This study is being initiated to create a normal database including measures of optic nerve head (ONH), peripapillary retinal nerve fiber layer (RNFL), and macula using the Heidelberg Spectralis OCT device.
- Trial name
- S-2013-3 (NCT02014688)
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Myopia
Comparing Myopia Control Efficacy in Children With 4 Methods: Orthokeratology, DIMS, DISK, and SVS.
The goal of this clinical trial is to learn if 3 optical interventions（DIMS, DISC and orthokeratology) to control myopia have different efficacy to slow myopia progression in children when the control is single focus…
- Trial name
- NCT06654180
- Testing
- Orthokeratology, defocus-incorporated multiple segment lenses (DIMS) spectacles, DISK
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Kaikai QIU
Glaucoma, Myopia
Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT
Because the measurement of the retinal nerve fiber layer thickness is very sensitive to the position of measurement, it may be incorrect in patients with the tilted disc.
- Trial name
- NCT00741130
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Other Disorders of Optic Disc, Bilateral
Video Diversion During Fundoscopic Exam in Children
Fundoscopy is an important aspect of the neurological examination, but can be challenging in uncooperative children. This study explored whether viewing a video (selected by patient or caregiver) during eye examination improves…
- Trial name
- CAFE (NCT01673815)
- Testing
- Video (played on a computer monitor)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Glaucoma, Open-Angle
Optic Nerve Head Strain as Biomarker for Glaucoma
The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.
- Trial name
- NCT06240312
- Testing
- Images of eye at 2 eye pressures
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetic Retinopathy
Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR)
To evaluate the effect of intravitreal bevacizumab on the course of diabetic retinopathy in cases with the signs of active progressive PDR
- Trial name
- NCT00370721
- Testing
- bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma
ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function
The aim is to determine which approach, immediate argon laser peripheral iridoplasty or conventional systemic medical treatment efficiently breaks acute angle closure attack without consequent visual morbidities.
- Trial name
- Iridoplasty (NCT00485238)
- Testing
- Argon laser Iridoplasty, Intravenous acetazolamide
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- National University Hospital, Singapore
Corneal re-Epithelialization
A Study to Assess the Safety, Tolerability and Effect of Nexagon™ Applied to the Eye After PRK Laser Eye Surgery for Nearsightedness
Phase 1 randomized, prospective, double-masked, vehicle-controlled, dose-escalation study to evaluate the safety, tolerability and clinical effect of Nexagon™ in subjects following bilateral PRK for the correction of mild to…
- Trial name
- NCT00654550
- Testing
- Nexagon™ or Nexagon™ vehicle
- Where
- New Zealand
- Volunteers
- 24 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Glaucoma
Comparison Between an Electronic Mobile Device and Optical Coherence Tomography to Determine Cup-to-disc Ratio
This study was a non-inferiority trial with masked data analysis. Individuals ranging from 18 to 60 years from both genders that met the pre-defined criteria were included.
- Trial name
- NCT02988752
- Testing
- Electronic Mobile Device, Optical Coherence Tomography
- Where
- Brazil
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Clinica Oftamologica Zona Sul
Normal Tension Glaucoma
Water Drinking Test Study and Disc Hemorrhages in Normal Tension Glaucoma
Disc hemorrhages are a known risk factor for progression of glaucoma. A positive water drinking test is also associated with progression of primary open glaucoma.
- Trial name
- NCT05075369
- Testing
- water drinking test
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Non-arteritic Ischemic Optic Neuropathy, Optic Disk Drusen
NA-AION Risk Factors: New Perspectives
The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION.
- Trial name
- NARROW (NCT05305079)
- Where
- 20 sites in United States, Australia and 7 more
- Volunteers
- 179 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Glaucoma, Open-Angle
Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma
Glaucoma is one of the leading causes of blindness worldwide that is a chronic public health problem. Unfortunately, glaucoma can be diagnosed when the disease reaches a certain level in today's conditions.
- Trial name
- NCT03966560
- Testing
- Brimonidine Tartrate, Dorzolamide (as Dorzolamide Hydrochloride) 20 Mg/mL and Timolol (as Timolol Maleate) 5 Mg/mL Eye Drops, Brinzolamide/Timolol 10 MG/1 ML-5 MG/1 ML Ophthalmic Suspension
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Afyon Kocatepe University Hospital
Optic Disc Edema, Endothelial Dysfunction
B-Complex: A Nutraceutical SANS Countermeasure
In this project, the investigators propose to test effectiveness of a daily nutraceutical supplement containing bioactive B vitamins to mitigate optic disc edema in astronauts.
- Trial name
- NCT05366933
- Testing
- Vitamin B-Complex Supplement
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Glaucoma, Suspect, Optic Nerve Hypoplasia and Abnormalities of the Central Nervous System
A More Engaging Visual Field Test to Increase Use and Reliability in Pediatrics
The majority of young children do not think that visual field (VF) testing of peripheral vision is similar to a game; therefore, it is not surprising that they have difficulty maintaining attention during VF testing and thus the…
- Conditions
- Glaucoma, Suspect, Optic Nerve Hypoplasia and Abnormalities of the Central Nervous System, Congenital Coloboma of the Optic Nerve, Optic Nerve Head Pits, Bilateral Congenital
- Trial name
- NCT02157025
- Testing
- Cartoon video fixation target and cartoon character voice audio instructions during Humphrey perimetry, Usual Care procedures during Humphrey perimetry for children
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Chronic Kidney Disease
Disc Edema in Patients With Chronic Kidney Disease
Papilledema is defined as swelling of the optic nerves often due to increased intracranial pressure. When present, it often indicates life-threatening lesions of the brain such as tumors, abscesses, meningitis, encephalitis…
- Trial name
- NCT00769834
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Glaucoma, Suspect, Glaucoma
Validation of an Automatic Analysis Algorithm of the Probability of Glaucoma From Optic Disc Images
Clinical, cross-sectional and prospective study to assess the images of the posterior pole of the retina of patients from the Glaucoma Unit of the IOBA and the Hospital Clínico Universitario de Valladolid during the period…
- Conditions
- Glaucoma, Suspect, Glaucoma, Ocular Hypertension
- Trial name
- NCT04972695
- Testing
- Fundus Photographs (retinographies)
- Where
- Spain
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Glaucoma, Primary Open Angle
Caffeine Consumption in Glaucoma Patients and Healthy Subjects
Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.
- Trial name
- NCT03675412
- Testing
- Caffeine tablet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Thyroid Associated Ophthalmopathy
Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy
The aim of the study is to compare the measurements of retinal nerve fiber layer (RNFL), macula and optical disc parameters obtained by optical coherence tomography (OCT), and intraocular pressure (IOP) between the patients with…
- Trial name
- NCT02766660
- Testing
- Optical Coherence Tomography
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Neon Hospital