Clinical trials: Optic Nerve Diseases
Neuropathic Pain, Diabetes Mellitus
Eye Movement Desensitization and Reprocessing (EMDR) as a Treatment for Chronic Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to investigate the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy in reducing pain intensity in individuals with chronic painful diabetic neuropathy (PDN).
- Trial name
- EMDR4CPDN (NCT06171230)
- Testing
- Eye Movement Desensitization and Reprocessing, Attention control phase
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Dijklander Ziekenhuis
Neuromyelitis Optica Spectrum Disorder
Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
The primary purpose of this study is to evaluate the safety and efficacy of ravulizumab in pediatric participants with Neuromyelitis Optica Spectrum Disorder (NMOSD).
- Trial name
- NCT05346354
- Testing
- Ravulizumab
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 12 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Parkinson Disease
The Effect of Eye Exercises in Parkinson's Disease
Parkinson's disease is commonly associated with impaired gait, postural instability, reduced physical function, and increased concern about falling, all of which contribute substantially to disability and reduced quality of life.
- Trial name
- NCT07525973
- Testing
- Supervised In-Center Eye Exercises
- Where
- Iran
- Volunteers
- 68 people
- Sponsor
- Pardis Specialized Wellness Institute
Ocular Injury, Optic Nerve Diseases
A Phase I Feasibility Study of an Intracortical Visual Prosthesis (ICVP) for People With Blindness
The purpose of this study is to determine the feasibility of producing artificial vision in persons with blindness. Study participants will have wireless electrical stimulators implanted into the cortical vision processing areas…
- Conditions
- Ocular Injury, Optic Nerve Diseases, Photoreceptor Degeneration, Blindness,Acquired
- Trial name
- ICVP (NCT04634383)
- Testing
- WFMA - wireless floating microelectrode array
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Illinois Institute of Technology
Ciliary Body and Choroid Melanoma, Medium/Large Size, Extraocular Extension Melanoma
Sorafenib, Carboplatin, and Paclitaxel in Treating Patients With Stage IV Melanoma of the Eye
This phase II trial is studying how well sorafenib works when given together with carboplatin and paclitaxel in treating patients with stage IV melanoma of the eye.
- Conditions
- Ciliary Body and Choroid Melanoma, Medium/Large Size, Extraocular Extension Melanoma, Iris Melanoma, Metastatic Intraocular Melanoma
- Trial name
- NCT00329641
- Testing
- carboplatin, paclitaxel, sorafenib tosylate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Uveal Melanoma
Melphalan Chemoreduction for Ocular Melanoma
The goal of this clinical trial is to investigate a new approach for treating large uveal melanomas, a type of eye cancer. The study aims to determine the effectiveness of using intra-arterial melphalan, a chemotherapy drug, to…
- Trial name
- MELCOM (NCT05893654)
- Testing
- Melphalan Injection, Plaque brachytherapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Visual Loss
Evaluation of a Scalable Educational Intervention for Adjustment and Coping to Vision Loss
The goal of this interventional study is to learn if an educational intervention improves awareness in people experiencing visual loss.
- Trial name
- NCT07715695
- Testing
- audiovisual educational intervention
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Brigham and Women's Hospital
Childhood Absence Epilepsy, Absence Seizures
Assessing Comorbidities in Epilepsy Using Eye Movement Recordings
This study wants to make it easier to find kids with a type of epilepsy called childhood absence epilepsy (CAE) who might have problems with ongoing seizures and thinking.
- Conditions
- Childhood Absence Epilepsy, Absence Seizures, Epilepsy Comorbidities
- Trial name
- ACER (NCT06310772)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eysz, Inc.
Chronic Venous Insufficiency, CVI
Clinical Study to Assess the Safety and Efficacy of Mechanochemical Ablation With Flebogrif in Patients With Great Saphenous Vein Insufficiency
The objective of the study is to collect clinical data of patients in whom Flebogrif® will have been used for mechanochemical ablation of incompetent veins in the follow-up period, as related to the safety, clinical…
- Trial name
- POLFLEB (NCT04558957)
- Testing
- FLEBOGRIF
- Where
- 4 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Balton Sp.zo.o.
Metastatic Uveal Melanoma
Efficacy and Safety of Pembrolizumab in Combination With Lenvatinib in Metastatic Uveal MElanoma Patients (PLUME)
Because we suspect that the benefit of anti-PD-1 in metastatic UM patients could vary according to previous exposure to Tebentafusp (better efficacy of anti-PD-1 after Tebentafusp), the combination of pembrolizumab and lenvatinib…
- Trial name
- PLUME (NCT05282901)
- Testing
- Pembrolizumab 25 MG/1 ML Intravenous Solution
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Institut Curie
Blindness
Sensory Substitution and Brain Plasticity Following Vision Loss
The goal of this clinical investigation is to learn how the brain responds when visual information is converted into patterns of sound or touch in blind and sighted participants.
- Trial name
- SenSubMRI (NCT07450677)
- Testing
- Electrotactile display (BrainPort), Vision-to-sound converter (AI Sight)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Optic Neuritis
Safety and Efficacy Study of Erythropoietin as add-on Therapy of Methylprednisolone to Treat Acute Optic Neuritis
The purpose of this study is to determine the safety and efficacy of erythropoietin as an add-on therapy to methylprednisolone in subjects with acute autoimmune optic neuritis.
- Trial name
- NCT00355095
- Testing
- Erythropoietin
- Where
- 3 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Acute Vestibular Syndrome, Vertigo
Quantitative Eye Movement Measurements in Patients with Acute Vestibular Syndrome
BACKGROUND: A chief complaint of acute vertigo/dizziness is related to about 2.1-7.1% of all emergency department (ED) visits. About 25% of all patients with acute prolonged vertigo meeting diagnostic criteria of AVS (acute…
- Conditions
- Acute Vestibular Syndrome, Vertigo, Stroke Acute, Acute Unilateral Vestibulopathy (AUV)
- Trial name
- NCT06668857
- Testing
- video-oculography
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Alexander Tarnutzer
Choroidal Melanoma, Indeterminate Lesions
Choroidal Melanoma Patient-Reported Outcome Study (CM-PRO) in a Subset of AU-011-301 (CoMpass) Subjects
To assess subject-centric evidence of QoL outcomes in a subset of subjects enrolled in the global Phase 3 AU-011-301 clinical trial.
- Conditions
- Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
- Trial name
- NCT07421739
- Testing
- Non-interventional, digital, patient-reported, study
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Aura Biosciences
Melanoma
Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma
This is a phase I/II clinical trial of a single dose of CD40L-augmented TIL administered in patients with advanced melanoma (Cohort 1: Cutaneous acral melanoma, cutaneous non-acral melanoma, (n=26); Cohort 2: Mucosal melanoma…
- Trial name
- NCT06961357
- Testing
- Cyclophosphamide, Fludarabine, Interleukin-2
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Healthy Male and Female Subjects, Healthy Elderly
Impact Of Everyday Light Exposure Patterns On Health
The aim of the present study is to characterize everyday light conditions of younger and older adults and to consider them in relation to cardiovascular, metabolic and psychological health.
- Trial name
- AgeLight (NCT06908395)
- Testing
- 10-day ambulatory assessment in everyday life combined with two laboratory office days
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- RWTH Aachen University
Uveal Melanoma
Prospective Registration Of Patient Data and Quality of Life in Eye Melanoma Patients
PROQEM is a prospective cohort study among patients diagnosed with uveal melanoma to assess quality of life before and in the first five years after treatment.
- Trial name
- PROQEM (NCT05377957)
- Testing
- Quality of life questionnaires, Discrete choice experiment, Shared decision-making analysis
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Leiden University Medical Center
Transverse Myelitis, Neuromyelitis Optica
Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch)
Transverse myelitis (TM) is an inflammatory disorder of the spinal cord that leads to disabilities of gait. Dalfampridine, a sustained-release potassium inhibitor has been shown to be effective in improving gait and other…
- Conditions
- Transverse Myelitis, Neuromyelitis Optica, Idiopathic Transverse Myelitis, Myelitis NOS
- Trial name
- NCT02166346
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Uveal Melanoma, Metastatic
Targeted Alpha Particle Radiotherapy for Metastatic Uveal Melanoma
The primary aim of the study is to establish the maximum-tolerated dose (MTD) of 225Ac-MTI-201 in participants with metastatic uveal melanoma.
- Trial name
- NCT05496686
- Testing
- 4.7 microCi 225Ac-MTI-201, 9.5 microCi of 225Ac-MTI-201, 19 microCi of 225Ac-MTI-201
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Modulation Therapeutics, Inc.
Health, Hypertension
Optical Coherence Tomography And NEphropathy: The OCTANE Study
Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes.
- Conditions
- Health, Hypertension, Chronic Kidney Disease
- Trial name
- NCT02132741
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
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