Clinical trials: Optic Neuropathy
Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension Treatment Trial
Idiopathic intracranial hypertension (IIH), also called pseudotumor cerebri, is a disorder of elevated intracranial pressure of unknown cause [Corbett, et al., 1982; Wall, et al., 1991].
- Trial name
- IIHTT (NCT01003639)
- Testing
- Acetazolamide, Formal weight loss counselling program
- Where
- 41 sites in United States, Canada
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Open Angle Glaucoma, Normal Tension Glaucoma
Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
- Conditions
- Open Angle Glaucoma, Normal Tension Glaucoma, Healthy
- Trial name
- LSFG Repro (NCT04014933)
- Testing
- LASER SPECKLE FLOWGRAPHY
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Optic Neuropathy
Biomechanics of Optic Neuropathy
The participant is being asked to be a subject in this research study because the participant may have a disorder that can cause optic nerve damage and impairment of his/her visual function which is called optic neuropathies…
- Trial name
- NCT02982499
- Testing
- magnetic resonance image (MRI), Optical Coherence Tomography (OCT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Miami
Diabetes Mellitus, Type 1, Monogenic Diabetes
Monogenic Diabetes Misdiagnosed as Type 1
The study has two aims: 1. To (1a) determine the frequency of monogenic diabetes misdiagnosed as type 1 diabetes (T1D) and (2) to define an algorithm for case selection. 2.
- Conditions
- Diabetes Mellitus, Type 1, Monogenic Diabetes, Neonatal Diabetes, Maturity-onset Diabetes in the Young (MODY)
- Trial name
- ADDAM (NCT03988764)
- Testing
- None AHT
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion
New Non-invasive Modalities for Assessing Retinal Structure and Function
This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other…
- Conditions
- Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion, Hemianopia, Leber Hereditary Optic Neuropathy
- Trial name
- NCT03475173
- Testing
- LSFG-NAVI
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Optic Neuritis
Effect of Phenytoin on the Ganglion Cell Layer in Patients With Optic Neuritis
Optic neuritis typically occurs in young (mean age, 32 years), female (77%) patients, and it presents as subacute monocular visual loss that develops over several days.
- Trial name
- NCT02939937
- Testing
- Phenytoin
- Where
- Iran
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Corneal Ectasia, Corneal Disease
Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics
The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with…
- Conditions
- Corneal Ectasia, Corneal Disease, Corneal Astigmatism, Keratoconus
- Trial name
- EyeTwin (NCT04475900)
- Testing
- Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany), Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany), Optic nerve head measurement
- Where
- Germany
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Optic Neuropathy
Repetitive Transorbital Alternating Current Stimulation for Optic Neuropathies
The purpose of this study is to test the efficacy and feasibility of an intervention protocol for home-based repetitive transorbital alternating current stimulation (rtACS) for the treatment of visual impairment in people with…
- Trial name
- NCT06662448
- Testing
- SAVIR Alpha Synch mobile (SASm)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Open Angle Glaucoma, Normal Tension Glaucoma
Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study
Glaucoma is a leading cause of blindness worldwide, whose treatment - intraocular pressure lowering - is only partially effective in preventing disease progression.
- Trial name
- NCT01840202
- Where
- Belgium
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Normal Tension Glaucoma
Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost
A randomized, multicenter, investigator-masked prospective study of NTG patients currently on latanoprost 0.005% monotherapy, to study the effect of IOP change with the introduction of netarsudil 0.02% vs brimonidine 0.1%.
- Trial name
- NCT06449352
- Testing
- Netarsudil, Brimonidine
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Westlake Eye Specialists
Multiple Sclerosis, NMO Spectrum Disorder
National, Multicentric Registry Study on Neuroimmunological Diseases in China
The aim of this study is to establish a real-world clinical neuroimmune disease research cohort, to follow up and observe the prognosis of patients with different subtypes and subgroups, and to provide support for the treatment…
- Conditions
- Multiple Sclerosis, NMO Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Myasthenia Gravis
- Trial name
- NIDBase (NCT06443333)
- Testing
- Data collection and follow-up observation, Data collection
- Where
- China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Anterior Ischemic Optic Neuropathy
Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy
Ischemic optic neuropathy is among the most common causes of serious impaired vision in the middle-aged and elderly population in the western world.
- Trial name
- NCT03401892
- Testing
- Dynamic Vessel Analyzer (DVA), Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Optical coherence tomography (OCT)
- Where
- Austria
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy, Multiple Sclerosis
Normal Chinese Lifespan Brain Charts Initiative (NCLBCI)
Major brain diseases (including neuroimmune diseases, neurodegenerative diseases, and cerebrovascular diseases) are leading causes of death and disability in humans.
- Conditions
- Healthy, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Neurodegenerative Diseases
- Trial name
- NCT06643858
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital