Clinical trials: Optical Coherence Tomography
Glaucoma, Tomography, Optical Coherence
The Diagnostic Performance of BMO-MRW and RNFL Thickness and Their Combinational Index Using Artificial Neural Network
This study evaluates the relationship between BMO-MRW and RNFL thickness measured by OCT. SD-OCT exam will be performed to all patients in this study.
- Trial name
- NCT03257020
- Testing
- SD-OCT
- Where
- South Korea
- Volunteers
- 402 people
- Sponsor
- Pusan National University Hospital
Anti-VEGF Treatment, Ranibizumab
Effectiveness of Biosimilar Ranibizumab in the Management of Diabetic Macular Edema
Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. Anti-VEGF agents are widely used to improve vision and reduce retinal swelling.
- Conditions
- Anti-VEGF Treatment, Ranibizumab, Biosimilar
- Trial name
- ERBDME (NCT07663370)
- Testing
- Ranibizumab biosimilar
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Alzheimer Disease, Dementia Alzheimers
Optical Coherence Tomography in Cerebral Amyloidosis
In this observational study, the investigators aim to evaluate whether changes in the retinal and choroidal circulation, as assessed by Optical Coherence Tomography (OCT) and the quantification of retinal amyloid deposits using…
- Conditions
- Alzheimer Disease, Dementia Alzheimers, Dementia, Lewy Body Disease
- Trial name
- NCT03472482
- Testing
- non-invasive retinal imaging
- Where
- Belgium
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pituitary Mass, Diagnoses Disease
Pituitary Gland Enlargement Was First Diagnosed by Optical Coherence Tomography (OCT)
OCT is now an established way to measure the thickness of the Retinal Nerve Fiber Layer (RNFL) in the retina of the eye. The thickness of the RNFL is always a reflection of the number of the RNFs in any particular area of the…
- Trial name
- OCT (NCT03087682)
- Testing
- Optical Coherence Tomography (OCT)
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Dr. S.S. Michel Clinic
Optical Coherence Tomography of Retina
Comparative Study of High Performance Low-Cost Optical Coherence Tomography
The purpose of this study is to complete performance testing of our custom optical coherence tomography (OCT) device to verify it can deliver retinal images of similar quality to a commercial OCT device.
- Trial name
- NCT05530460
- Testing
- retinal imaging with low-cost OCT device, retinal imaging with commercial OCT device
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Duke University
Exudative Age Related Macular Degeneration
The Spectralis-Cirrus Study
Retinal thickness measurement is one of the most important examinations in the follow up of exudative age-related macular degeneration.
- Trial name
- NCT00927303
- Testing
- Cirrus-Spectralis, Spectralis-Cirrus
- Where
- Austria
- Volunteers
- 110 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Myopia
Effect of Axial Length of the Globe on Retinal Nerve Fibre Thickness
the goal of this obsrevational study is to learn about retinal nerve fibres and if their numbers changed with axial length of the globe or not.
- Trial name
- NCT05716776
- Testing
- Optical coherence tomography (OCT)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Intracranial Atherosclerotic Stenosis
Multimodal Imaging Evaluation of Vulnerability of Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS
The primary objective of this study is to evaluate the vulnerability of intracranial and extracranial atherosclerotic plaques using HR-VWI, OCT, and RWS technologies, while exploring correlations among these three imaging…
- Trial name
- NCT07133451
- Where
- China
- Volunteers
- 561 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Retinal Dystrophies
SS-HH-OCT as a Novel Diagnostic Modality for Early-Onset Retinal Dystrophies (EORDs)
The goal of this observational study is to utilize a novel imaging system designed for high-resolution retinal imaging of neonates, infants and children to identify the signs of photoreceptor development and degeneration in…
- Trial name
- SS-HH-OCT (NCT06177977)
- Testing
- SS-HH-OCT
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Duke University
Tomography, Optical Coherence, Myocardial Revascularization
The FAST OCT Study
This trial is designed to associate angiography-based fractional flow reserve (3D-angio-based FFR) values with optical coherence tomography findings in pre- and post-percutaneous coronary intervention in patients with non-ST…
- Conditions
- Tomography, Optical Coherence, Myocardial Revascularization, NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
- Trial name
- NCT04683133
- Testing
- Optical coherence tomography assessment
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Coronary Artery Disease
The Optical Coherence Tomography Drug Eluting Stent Investigation
The objective of this study is to evaluate the completeness of struts coverage and vessel wall response to the new generation JACTAX drug-eluting stent vs Taxus stent in de novo coronary artery lesions at 6 months post index…
- Trial name
- OCTDESI (NCT00776204)
- Testing
- JACTAX Drug eluting stent, JACTAX LD drug eluting stent, Taxus Libertè
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Boston Scientific Corporation
Enucleated; Eye, Evisceration; Traumatic, Eye
Click2Print Artificial Eyes
To undertake a randomised crossover trial in human subjects the Click2Print ocular prosthesis versus an analogue ocular prosthesis demonstrating non-inferiority in the assessment of ocular prosthesis motility, cosmesis, fit and…
- Trial name
- Click2Print (NCT05093348)
- Testing
- Click2Print artificial eye, Hand-made artificial eye
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Acute Myocardial Infarction
Vessel Wall Response of the Zotarolimus Drug-eluting Stent Implanted in AMI Assessed by Optical Coherence Tomography
The objective of this study is to evaluate the completeness of struts coverage and vessel wall response (strut malapposition, neointima disomogeneities in texture) to the ENDEAVOR drug-eluting stent vs the DRIVER stent (bare…
- Trial name
- OCTAMI (NCT00704561)
- Testing
- ENDEAVOR® drug-eluting stent (Medtronic, Santa Rosa, CA), DRIVER bare metal stent (Medtronic, Santa Rosa, Ca), Coronary stent implantation
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Coronary Artery Disease, Coronary Artery Stenosis
Vessel Imaging Using Optical Coherence Tomography for Plaque Morphology and Vessel Fractional Flow Reserve
The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between mopphometric indices: luminal and qualitative parameters assessed by optical coherence tomography (OCT)…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Tomography, Optical Coherence, 3D-angio-based FFR
- Trial name
- VISION-FFR (NCT06844942)
- Testing
- vessel Fractional Flow Reserve
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction
OCT Based Edge and In-stent Vascular Response After Cordimax Stent in patIents With NSTE-ACS
This study evaluates the completeness of strut coverage and vessel wall response, at different time points (3-6-12 Months), following CordimaxTM stent implantation in patients with non-ST elevation acute coronary syndrome
- Trial name
- NCT02868203
- Testing
- OCT, eLuting stent
- Volunteers
- 80 people
- Sponsor
- Xijing Hospital
Microvascular Angina
The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients With Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI).
Microvascular angina is thought to affect around 112 million patients worldwide. However, this figure is underestimated due to the difficulty of making the diagnosis.
- Trial name
- EYE-NOCA (NCT06692751)
- Testing
- Blood sampling, Ophthalmological examination, angina severity questionnaire
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Optical Coherence Tomography, Optical Coherence Tomography Angiography
Normative Database of Healthy Subject Vascular Density Using Spectralis Heidelberg® Optical Coherence Tomography Angiography
Optical coherence tomography angiography (OCT-A) is a determinant progress to study retinal and choroidal vasculature without using a dye injection.
- Trial name
- COPENBASE (NCT06043622)
- Testing
- Optical coherence tomography angiography, ophthalmological exam
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
No Eye Disease
Optical Coherence Tomography (OCT) Data Collection Study
Collect OCT data to evaluate the range and age trend of eye measurements.
- Trial name
- NCT01459731
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Optovue
True Coronary Bifurcation Lesions
COmplex BifuRcation Lesions: a Comparison Between the AXXESS Device and Culotte Stenting: an Optical Coherence Tomography (OCT) Study
Treatment of bifurcation lesions with drug-eluting stents (DES) (especially when a double stent technique is used) is associated with a higher risk for stent thrombosis.
- Trial name
- COBRA (NCT01486095)
- Testing
- AXXESS + Biomatrix Biolimus Eluting stent, Culotte technique with Xience V or Xience Prime stents
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Percutaneous Coronary Revascularisation, Complex Coronary Lesion
Use of Physiology to Evaluate Procedural Result After PCI CTO
ULTRA-CTO is a prospective multicentre non-randomised investigator-initiated trial designed to enrol 200 subjects with an indication for percutaneous coronary intervention (PCI) of chronic total occluded (CTO) coronary artery.
- Trial name
- ULTRA-CTO (NCT04780971)
- Testing
- post-PCI Pd/Pa
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Isala