Clinical trials: Optical Guided Surgery
Lung Cancer
Evaluation of IRDye800CW-nimotuzumab in Lung Cancer Surgery
The purpose of this study is to determine the safety, optimal dose and imaging time of the investigational product, IRDye800CW-nimotuzumab for use as a near infrared imaging probe for image-guided surgery during lung cancer…
- Trial name
- NCT04459065
- Testing
- IRDye800CW-nimotuzumab
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of Saskatchewan
Breast Cancer
Fluorescence Guided Surgery in Breast Cancer
A need for further investigation for fluorescence image-guided surgery in breast conserving surgery (BCS) has arisen following the results obtained from a phase I feasibility breast cancer trial (BIRDYE study: ABR NL…
- Trial name
- MARGIN (NCT02583568)
- Testing
- Bevacizumab-800CW
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- University Medical Center Groningen
Diabetic Retinopathy
Study on Precision Treatment of Diabetic Retinopathy Macular Edema Guided by Real-time OCT During Operation
Select Proliferative Proliferative diabetic retinopathy(PDR) patients who are planning to undergo vitrectomy for informed notification. After obtaining informed consent, vitrectomy will be performed.
- Trial name
- NCT05138029
- Testing
- Ranibizumab Injection [Lucentis], Inner limiting membrane stripping, Dexamethasone intravitreal implant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Nantong University
Thyroid Carcinoma, Surgery
Thyroid Cancer and Central Lymph Node Metastases Detection Using Bevacizumab-IRDye800CW
Background: Papillary thyroid cancer (PTC) patients often develop central lymph node metastases (CLNM), which pose a high risk of disease recurrence.
- Trial name
- TARGET-beva (NCT06095362)
- Testing
- Bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Optical Guided Surgery
Safety Validation of EndoSWIR Device
Head and neck cancer has an incidence of 600,000 cases per year worldwide (6th among cancers) and cause 380,000 death per year. Surgical resection is guided by the surgeon's inspection and palpation of the tumor.
- Trial name
- ENDO-AMYG (NCT04274309)
- Testing
- EndoSWIR
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Grenoble
Gynecologic Cancer, Cervical Cancer
Intraoperative Microscopic Assessment of Lymph Node Status in Gynecological Malignancies
The IMAGINE study is a monocentric, observational, prospective study evaluating the diagnostic performance of Full-Field Optical Coherence Tomography (FF-OCT) combined with Dynamic Cell Imaging (DCI) (Van Gogh System, AQUYRE…
- Conditions
- Gynecologic Cancer, Cervical Cancer, Endometrial Cancer, Ovary Cancer
- Trial name
- IMAGINE (NCT07702721)
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypoparathyroidism Postprocedural, Hypocalcemia
Near Infrared (NIR) Autofluorescence Image-guided Thyroid Surgery
The objective of this ongoing randomized controlled trial is to examine whether the use of intra-operative NIR(near infrared) camera can reduce the number of patients who experience transient or persistent hypoparathyroidism…
- Conditions
- Hypoparathyroidism Postprocedural, Hypocalcemia, Surgery--Complications
- Trial name
- NCT04193332
- Testing
- NIR optical imaging camera
- Where
- 2 sites in Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer
Lidocaine Mucilage-ICG as an Optical Agent for Tumor Delineation During Breast-conserving Surgery
Around 15%-30% of patients receiving breast-conserving surgery (BCS) for invasive breast carcinoma or ductal carcinoma in situ (DCIS) need a reoperation due to tumor-positive margins at final histopathology.
- Trial name
- LI-CTD (NCT04438577)
- Testing
- Lidocaine mucilage-ICG
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shantou Central Hospital
Hyperparathyroidism, Primary, Parathyroid Neoplasms
WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making
Primary hyperparathyroidism is usually cured by removing the single over-active parathyroid adenoma. During surgery, however, surgeons often see a thin rim of normal parathyroid tissue that still "glows" under a near-infrared…
- Conditions
- Hyperparathyroidism, Primary, Parathyroid Neoplasms, Parathyroid Adenoma, Hypocalcemia
- Trial name
- WHITE CAP-PTS (NCT07043010)
- Testing
- Near-Infrared Parathyroid Tissue Sensor Imaging (PTS), Rim-Preservation Technique, En-bloc Resection Technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Pancreatic Cancer, Pancreatic Adenocarcinoma
Near-infrared Image Guided Surgery in Pancreatic Adenocarcinoma
There is a need for better visualization of resection margins and detection of small tumor deposits during surgery for pancreatic cancer.
- Trial name
- PENGUIN (NCT02743975)
- Testing
- Bevacizumab-800CW
- Where
- 3 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Accuracy of Surgical Guide in Computer Guided Implantology
Assessment of the Accuracy of Surgical Guide Designed From Dental Model Optical Scan Versus Impression Inversion With Markers Techniques in Computer Guided Implantology. Randomized Clinical Trial.
Dental model cast accuracy can be affected by many variables as tray material, impression material and time elapsed before pouring the impression.
- Trial name
- NCT03367949
- Testing
- Surgical guide designed from Impression inversion with markers
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Retinal Detachment, Epiretinal Membrane
PIONEER: Intraoperative and Perioperative OCT Study
OCT provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. Much of this information is not able to be recognized by a clinician.
- Conditions
- Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
- Trial name
- PIONEER (NCT02423161)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Macular Hole, Epiretinal Membrane
Optical Coherence Tomography - Rescan During Dissection of Macular Membranes
In our study , the investigators will use the microscope with OCT ( Lumera with RESCAN OCT ) coupled to assess the extent , depth and change of retinal architecture in the perioperative period .
- Conditions
- Macular Hole, Epiretinal Membrane, Traction Syndrome Vitreomacular, Proliferative Vitreoretinopathy
- Trial name
- NCT02748421
- Testing
- Lumera Microscope with OCT RESCAN, Conventional Microscope
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo