Clinical trials: Optical Imaging
Multiple Sclerosis
Evaluation of the Relationship Between Optic Nerve Diameter and Optic Nerve Sheath Diameter Measured by Transorbital Sonography With Clinical, Radiological, and Electrophysiological Parameters in Multiple Sclerosis Patients
The primary aim of this study is to evaluate the reliability of optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) measurements made with transorbital sonography (TOS) and magnetic resonance imaging (MRI) in…
- Trial name
- NCT06533930
- Testing
- Transorbital Sonography, Orbita Magnetic Resonance Imaging, Visual Evoked Potentials
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Advanced Glaucoma, Failed Trabeculectomies
Imaging Ahmed Glaucoma Tubes With a Pericardial Graft and Tissue Glue or Partial-Thickness Scleral Flap and Sutures
When implanting an Ahmed glaucoma tube, a scleral flap is usually created to cover the tube, and the conjunctiva is stitched back in place with nylon 10-0 sutures.
- Trial name
- NCT00453024
- Testing
- Pericardial graft & tissue glue, scleral flap & sutures
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Port-wine Stain
Evaluate the Port-wine Stain Birthmark Treatment Before and After Pulsed Dye Laser Treatment
Port-wine stain is a congenital, progressive vascular malformation of human skin involving post-capillary venules that occurs in an estimated 0.3% of children and can alter personality development and psychological in children.
- Trial name
- NCT01774552
- Testing
- Photo Acoustic Microscopy and Optical Coherence tomography
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Celiac Disease, Healthy
Imaging the Duodenum Using an Optical Frequency Domain Imaging OFDI Capsule
The study is being done to assess the tolerability and feasibility of a tethered OFDI capsule to image the duodenum. A total of 108 participants (36 healthy and 72 with clinically suspected or diagnosed Celiac disease) will be…
- Trial name
- NCT02202681
- Testing
- OFDI Capsule
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
PAD, Optical Imaging
Pulse Wave Velocity Imaging in the Assessment of PAD
The purpose of this study is to predict the outcome of peripheral revascularization surgery by use of a new technology developed by our team, Pulse Wave Velocity imaging (PWVI), which has the capability to detect pulse transit…
- Trial name
- PWVi (NCT03516383)
- Testing
- PWVi
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Glaucoma, Retinal Disease
The EASE Study - Human Factor and Usability Testing of a Binocular OCT System
Ophthalmology is among the most technology driven of all medical specialties, with advanced medical imaging devices - and specialised computer software - increasingly adopted for routine clinical use.
- Conditions
- Glaucoma, Retinal Disease, Strabismus, Healthy Volunteers
- Trial name
- EASE (NCT02822612)
- Testing
- Binocular OCT prototype
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University College, London
Healthy
Subfoveal Choroidal Thickness in Thai Population
The purpose of this study was to determine the subfoveal choroidal thickness in normal Thai eyes and study the associations with gender, age, refractive error and axial length using spectral-domain optical coherence tomography…
- Trial name
- NCT02551601
- Testing
- measure subfoveal choroidal thickness
- Where
- Thailand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Cardiomyopathies
Body Surface Area Prediction Impacts on Ventricular Dilatation Prevalence
The goals of this observational study are to investigate the accuracy of different predictive equations for body surface area (BSA) estimation and to evaluate the impact of different BSA normalizations on ventricular dilatation…
- Trial name
- NCT06939205
- Testing
- Assessment of body surface area and assessment ventricular dilatation prevalence
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Retinal Microcirculation Disorder
Influence of Daily Activities on Retinal Microcirculation
The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the…
- Trial name
- NCT03416088
- Testing
- Beverage consumption, Daily reading, Body motion
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Jiannan Huang
Glaucoma, Hypertension
Know Your Pressures NYC
Dr. Lisa A. Hark (PI and Study Chair) and an interdisciplinary team have designed "Know Your Pressures NYC" to conduct blood pressure (BP)/glaucoma screenings in adults age 40+ to identify undiagnosed and/or uncontrolled…
- Conditions
- Glaucoma, Hypertension, Glaucoma, Suspect, Elevated Blood Pressure
- Trial name
- NCT05992415
- Testing
- Virtual Automated Navigator Intervention with Health Education, Usual Care
- Where
- United States
- Volunteers
- 7,085 people, healthy volunteers welcome
- Sponsor
- Columbia University
Dry Eye Syndrome, Epiphora
Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome.
The primary aim of the study is to investigate whether optical coherence tomography (OCT) may be a useful tool for investigating the in-vivo histology of ocular structures in patients with tear film pathology.
- Conditions
- Dry Eye Syndrome, Epiphora, Sjögren's Syndrome
- Trial name
- OCT (NCT02849093)
- Testing
- Non-invasive OCT imaging
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bedford Hospital NHS Trust
Breast Cancer
Digital Breast Tomosynthesis Guided Tomographic Optical Breast Imaging (TOBI)
Screening for breast cancer improves early detection of aggressive cancers and has been shown to reduce breast cancer related mortality.
- Trial name
- NCT02033486
- Testing
- TOBI + DBT
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Benign Breast Tumors, Malignant Breast Tumours
Clinical Explorative Optical Breast Investigations
This study evaluates diffuse reflectance spectroscopy and photoacoustic imaging for differentiating healthy, benign, and malignant breast tissue by identifying their optical profiles.
- Conditions
- Benign Breast Tumors, Malignant Breast Tumours, Healthy
- Trial name
- CLEO-B (NCT06857669)
- Testing
- Diffuse reflectance spectroscopy and Photoacoustic imaging,
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Region Skane
Skin Diseases, Healthy Skin
An Observational Study to Assess Objective Skin Pigmentation Variation.
Accurate assessment of skin pigmentation is essential in dermatology for properly diagnosing and managing a wide range of skin conditions.
- Trial name
- SKIN-IMAGING (NCT07091604)
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Breast Cancer
Adjunctive Efficacy Study Of The SoftScan® Optical Breast Imaging System
The primary study endpoint -SoftScan adjunctive accuracy- will be used to test the hypothesis that the adjunctive combination of the SoftScan with x-ray mammography provides diagnostic accuracy that is significantly better than…
- Trial name
- NCT00267449
- Testing
- SoftScan Optical Breast Imaging System
- Where
- 6 sites in United States, Canada
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- ART Advanced Research Technologies Inc.
Non-melanocytic Skin Tumors, Melanocytic Skin Tumors
In-vivo Optical Coherence Tomography Imaging in Dermatooncology
In vivo differentiation of benign and malignant skin lesions is a fundamental issue in clinical dermatology. Malignant skin diseases are known to be accompanied by structural alterations.
- Trial name
- NCT01680562
- Testing
- in-vivo skin tumor imaging via optical coherence tomography
- Where
- Austria
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
Blood Flow of Ophthalmic Artery and Glaucoma
The main purpose of this project is to investigate the blood flow of the ophthalmic artery (OA) in patients with ocular hypertension, high tension glaucoma and normal tension glaucoma.
- Trial name
- NCT02656979
- Testing
- Latanoprost
- Where
- Sweden
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Umeå University
Healthy, Myopia
Ocular Imaging With Spectral Domain Optical Coherence Tomography
The purpose of this study is to analyze macular retinal thickness and macular volume using the spectral domain - optical coherence tomography (SD-OCT) in normal eyes and in eyes with various ocular diseases.
- Conditions
- Healthy, Myopia, Hypermetropia
- Trial name
- NCT00926549
- Testing
- Spectral domain-OCT (Cirrus™ HD-OCT, Carl Zeiss Meditec AG)
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yonsei University