Clinical trials: Optical Imaging
Pregnancy
Evaluation of Choroidal Thickness During Pregnancy Using Enhanced Depth Imaging Optical Coherence Tomography
The purpose of this study is to evaluate choroidal thickness and volume during the third trimester of pregnancy by comparison with a group of age-matched non-pregnant healthy group of women
- Trial name
- NCT02024048
- Testing
- OCT
- Where
- Portugal
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Gaia Hospital
Dehydration
Transdermal Optical Imaging (TOI) as a Non-invasive Measure to Detect Changes in Hydration Status in Healthy Adults and Athletes
The primary objective of this study is to analyze smart phone-based Transdermal Optical Imaging (TOI) features to develop a model that can discern hydration status, including: 1) at various timepoints throughout a 24-hour period…
- Trial name
- NCT06212518
- Testing
- GENPOP ad libitum fluid intake, GENPOP fluid restriction, ATHLETE ad libitum fluid intake
- Where
- 4 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Beta-Thalassemia
Choroidal Thickness in Beta-thalassemia Patients
The purpose of this study is to examine choroidal thickness in beta-thalassemia patients and compare it to the one of healthy controls.
- Trial name
- NCT04067258
- Testing
- EDI-OCT
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital of Patras
Giant Cell Arteritis, Polymyalgia Rheumatica
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR).
- Trial name
- GCAIO (NCT06460142)
- Testing
- Aortic/ cardiac magnetic resonance imaging, Vascular ultrasound, Transorbital Ultrasound
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Acute Lung Injury
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs
Seriously ill patients may develop a complication called acute lung injury (ALI), a form of inflammation in which lung tissue is filled by fluid containing white blood cells called neutrophils.
- Trial name
- NAP (NCT01532024)
- Testing
- Microdose of NAP
- Where
- 3 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Blood Pressure
Comparison of Blood Pressure Measurements Between Transdermal Optical Imaging and Standard of Care
Participants (patients and volunteers) will be recruited to have their blood pressure measured by standard blood pressure assessment methods while having their face video recorded.
- Trial name
- NCT04539860
- Testing
- Transdermal Optical Imaging
- Where
- 3 sites in Canada, China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Epilepsy
Evaluation of Optical Pumping Magnetometer Sensors for MagnetoEncephaloGraphy Imaging
This research is a feasibility study on a new generation of brain magnetic activity sensor which should allow the development of this modality, until now limited by its cost to a few large university centers.
- Trial name
- OPM (NCT04694313)
- Testing
- OPM
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Optic Nerve Disease
DTI & DIR in Optic Neuritis
To evaluate the role of Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI) in the assessment of optic neuritis and to correlate imaging findings with clinical and visual outcomes.
- Trial name
- DTI & DIR (NCT07748819)
- Testing
- MRI
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Assiut University
Blindness
Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours
The purpose of this study is to provide data that would give the investigators a better understanding of the physiologic changes that occur and may contribute to post operative blindness.
- Trial name
- NCT00875043
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Myofascial Pain
Multi-modal Imaging of Myofascial Pain
The goal of this study is to develop new imaging biomarkers for quantitative assessments of myofascial pain.
- Trial name
- NCT06036524
- Testing
- Multi-modal, multi-parametric, multiscale imaging of the myofascial unit
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dehydration
Utility of Transdermal Optical Imaging (TOI) as a Non-invasive Measure of Hydration Status: Phase 3a for Model Development
The primary objective of this study is to analyze smart phone-based Transdermal Optical Imaging (TOI) features to develop a model that can discern hypohydration from euhydration status including 1) a small feasibility study for…
- Trial name
- NCT06044610
- Testing
- GENPOP Passive dehydration (75% reduction in fluid intake, GENPOP Ad lib fluid intake, EXERCISE without fluid replacement
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Glaucoma, Primary Open Angle
Adaptive Optics Retinal Imaging
The objective of the study is to collect and assess adaptive optics (AO) retinal images from human subjects in support of projects to demonstrate, advance, and enhance clinical use of AO technology.
- Trial name
- NCT05370287
- Testing
- oxygen inhalation, Adaptive optics imaging
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Colonic Polyp, Colonic Diseases
Optical Polyp Testing for In Vivo Classification
Small growths detected in the colon (polyps) during a colonoscopy may or may not have the potential to develop into cancer. However, since visual inspection alone cannot separate all potentially harmful polyps from harmless ones…
- Conditions
- Colonic Polyp, Colonic Diseases, Colonic Neoplasms, Colonic Adenoma
- Trial name
- OPTIC (NCT03139942)
- Testing
- Optical spectral reflectance and autofluorescence imaging
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cognition
Testing and Calibration of Non-Invasive Optical Imaging Technology for Functional Brain Imaging
Background: Non-invasive functional near infrared (fNIR) imaging techniques use infrared light to detect changes in blood volume and oxygen levels during brain activity.
- Trial name
- NCT01212029
- Testing
- Behavioral measures, fNIRS Devices & Application, Physiological measures
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Idiopathic Intracranial Hypertension
MR Lymphatic Imaging in Idiopathic Intracranial Hypertention
In the brain and its borders, blood vessels coexist with lymphatic vessels exclusively in the dura mater, the outermost layer of meninges.
- Trial name
- LYMPHIMAGIIH (NCT05762367)
- Testing
- 3T MRI with Gadobutrol injection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy Adult
Optical Imaging of Retinal Vascular Metrics Under Different Dietary Conditions
In a typical clinical setting, patient eating habits are not controlled when performing optical coherence tomography (OCT) imaging for retinal diagnostics.
- Trial name
- NCT07818239
- Testing
- Consumption of a high fat meal, Consumption of a high carbohydrate meal
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Age Related Macular Degeneration
A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)
This study proposes to use a new instrument (AO-OCT/AF: adaptive optics - optical coherence tomography/autofluorescence) combined with a data processing method to image the retinal pigment epithelium (RPE) of the eye in normal…
- Trial name
- NCT03963817
- Testing
- adaptive optics AO-OCT/AF instrument
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Dental Caries (Diagnosis), Dental Plaque
Clinical Assessment of Caries and Dental Plaque Based on Auto-fluorescence Imaging System
The purpose of this study was to evaluate the applicability of auto-fluorescence imaging system to detect and quantify caries and dental plaque.
- Conditions
- Dental Caries (Diagnosis), Dental Plaque, Optical Imaging
- Trial name
- NCT03038412
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hui Chen
Breast Tumor
Monitoring and Predicting Breast Cancer Neoadjuvant Chemotherapy Response Using DOSI
The purpose of this research study is to help us learn if an experimental imaging device called Diffuse Optical Spectroscopic Imaging (DOSI) can monitor tumor shrinkage during chemotherapy treatment and can predict if the tumor…
- Trial name
- NCT02725658
- Testing
- DOSI
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Beckman Laser Institute and Medical Center
Pectus Excavatum
Quantification of Chest Wall Changes After Nuss Bar Removal Utilizing Three-dimensional Optical Surface Scans
Pectus excavatum is the most common anterior chest wall deformity that affects up to 1:400 of newborns. If an operative correction is indicated, patients are often operated via the Ravitsch or Nuss bar procedure. The latter (i.e.
- Trial name
- CHEST (NCT04052321)
- Testing
- 3D optical surface scan
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum