Clinical trials: Optimization
Lymphedema of Upper Limb
Novel MRI Techniques on Evaluation of Lymphedema
In this project, the investigators aim to investigate the imaging approaches for breast cancer-related secondary lymphedema. The clinical study aims to optimize the conventional MRI methods for mapping lymphedema and assess the…
- Trial name
- NCT05804643
- Testing
- Diffusion magnetic resonance imaging
- Where
- Taiwan
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sports Betting Players
Optimization of the Self-exclusion Procedure
It has been shown that self-excluded gamblers are very heavy gamblers, and that it is not possible to distinguish between those who report self-exclusion for addictive reasons and those who self-exclude for commercial reasons…
- Trial name
- OSE (NCT04802226)
- Testing
- self exclusion procedure
- Where
- France
- Volunteers
- 2,554 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Spinal Cord Diseases, Spinal Cord Injuries
Optimization of Adaptive Rowing Seating
Adaptive sports programs are integral components to combating Veteran isolation, promoting wellbeing and seeking to build teams, networks, communities.
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neurodegenerative Disorders, Cerebrovascular Accident With Associated Sequelae
- Trial name
- OARS (NCT07099625)
- Testing
- Adaptive Indoor Rowing Seat, Paddle Sport adaptive seating system
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Tourette Syndrome
Safety, Tolerability, and Efficacy of NBI-98854 for the Treatment of Pediatric Subjects With Tourette Syndrome
This is a Phase 2b, randomized, double-blind, placebo-controlled, dose-optimization study to evaluate the efficacy, safety, and tolerability of NBI-98854 titrated to the subject's optimal dose administered once daily (qd) for a…
- Trial name
- NCT03325010
- Testing
- Valbenazine
- Where
- 35 sites in United States, Puerto Rico
- Volunteers
- 127 people
- Sponsor
- Neurocrine Biosciences
Breast Cancer, Axillary Lymph Node Metastasis
Axillary Lymph Node Changes After Neoadjuvant Therapy In Breast Cancer
The purpose of this study is to improve regional surgical treatment in breast cancer patients with axillary lymph node metastases (cN+) who received neoadjuvant systemic treatment (NAST) by using ultrasound elastography.
- Trial name
- NCT07428720
- Testing
- Ultrasound Elastography
- Where
- Slovenia
- Volunteers
- 97 people
- Sponsor
- Institute of Oncology Ljubljana
Patients Undergoing Surgery
Is an Online-tool Capable of Improving Patients' Outcomes After Surgery?
Recovery after the surgery depends on psychological factors such as preoperative information, expectations, and surgery-associated anxiety.
- Trial name
- NCT04669379
- Testing
- EXPECT: Preoperative optimization of patient's expectations
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- Philipps University Marburg
Healthy
Non-contrast Enhanced Cardiac Magnetic Resonance Normal Values and Imaging Protocols
One of the main problems in cardiac magnetic resonance (MR) investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations and it is…
- Trial name
- CMR-TECH (NCT01728597)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Breast Neoplasms
Investigation of Diagnostic Improvement Gained Through Optimization of MR Methods for Breast Cancer Detection
In a single MRI exam on a research scanner, each lesion will be categorized using the BI-RADS MRI score, which utilizes the DCE data alone, and then again using a modified BI-RADS score, which utilizes both DWI and DCE data.
- Trial name
- BCD (NCT02411760)
- Testing
- 3 Tesla Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Cognitive Functions
Cognitive Functions in Women's National Sitting Volleyball Players
This study investigates the effects of a multidimensional, 13-component sleep hygiene optimization intervention on cognitive performance (executive functions, cognitive flexibility, and psychomotor speed) and objective sleep…
- Trial name
- NCT07857720
- Testing
- Multidimensional Sleep Hygiene Optimization Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Coronary Artery Disease
MCG Algorithm Optimization Study in Patients With Coronary Artery Stenosis
This prospective, multicenter study aims to optimize the Magnetocardiography (MCG) algorithm for detecting myocardial ischemia in patients with coronary artery stenosis.
- Trial name
- NCT07888465
- Volunteers
- 165 people
- Sponsor
- AMCG
Heart Failure With Reduced Ejection Fraction
Dashboard Activated Services and Tele-Health for Heart Failure
The Dashboard Activated Services and tele-Health for Heart Failure (DASH-HF) study is a pragmatic randomized controlled trial of a quality improvement (QI) intervention of a prospective panel management intervention to optimize…
- Trial name
- DASH-HF (NCT05001165)
- Testing
- Proactive Panel Management Clinics for HFrEF
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Sedentary Behavior, Screen Time
StandUPTV: Reducing Sedentary Screen Time in Adults
The goal of this study is to develop an optimized intervention for reducing leisure sedentary screen time (SST) in middle-aged adults with overweight or obesity.
- Conditions
- Sedentary Behavior, Screen Time, Physical Activity, Sleep
- Trial name
- StandUPTV (NCT04464993)
- Testing
- Device-based feedback, self-monitoring, and education: CORE, Sedentary Screen Time lockout: LOCKOUT, Context-based prompts: TEXT
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Perioperative Hemodynamic Optimization, Cardiac Surgery
Goal-directed Resuscitation in High-risk Patients Undergoing Cardiac Surgery
The primary aim of the study is to investigate whether a goal-directed resuscitation therapy in high-risk patients through cardiac index optimization using the LiDCO Rapid device reduces complications after cardiac surgery.
- Trial name
- GRICS (NCT01470976)
- Testing
- Goal-directed Resuscitation Therapy (GDT), Standard protocol
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo
Heart Failure
The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients
The SmartHF study is a 12-week prospective randomized controlled multicenter clinical trial. This study will investigate the efficacy of an adaptive web application to facilitate guideline-directed medical therapy (GDMT)…
- Trial name
- SmartHF (NCT05858320)
- Testing
- SmartHF application
- Where
- 5 sites in United States
- Volunteers
- 225 people
- Sponsor
- University of Michigan
Congenital Hyperinsulinism, Neuroblastoma
18F-DOPA II - PET Imaging Optimization
A single centre non-randomized, non-blinded phase III prospective cohort study of 18F-DOPA PET/CT imaging in specific patient populations: 1. Pediatric patients (less than 18 years old) with congenital hyperinsulinism. 2.
- Conditions
- Congenital Hyperinsulinism, Neuroblastoma, Parkinson Disease, Lewy Body Disease
- Trial name
- NCT04706910
- Testing
- 18F-DOPA, Furosemide Injection
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University of Alberta
Celiac Disease in Children, Nutrition Disorder, Child
GF-NOURISH (Gluten Free Nutrition Optimization Through Ultra-processed Food Reduction and Improved Strategies for Health)
The investigators propose the Gluten Free Nutrition Optimization through Ultra-processed food Reduction and Improved Strategies for Health (GF-NOURISH) study to demonstrate the feasibility and success of a nutritional education…
- Trial name
- GF-NOURISH (NCT06356220)
- Testing
- Gluten-Free Diet Education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Transplant Dysfunction
Hemodynamic Optimization During Single Kidney Transplantation With MostcareUP
There are currently no clear recommendations on hemodynamic targets during kidney transplantation and most anesthesiologists rely on empiric or obsolete parameters such as CVP.
- Trial name
- NCT03446196
- Testing
- Fluid replacement based on MOSTCARE up
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Diabetes Mellitus, Type 1, Metabolic Disorder
A Telematic Program for Optimization of Metabolic Control in Diabetes Mellitus Type 1 (DM1) Patients
A greater visit frequency between the diabetes mellitus 1 (DM1) patient and the medical team increases the possibilities to improve metabolic control. The support of telematic visits can support the patient and the health system.
- Trial name
- NCT01337141
- Testing
- Control, Telecare system
- Where
- 5 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders
Autologous Blood Transfusion
Explore the Feasibility of Modified Blood Collection Method
Blood collection method: routine preparation according to predeposit autologous blood transfusion. Control group: according to the conventional blood collection method, the bevel of the needle head of the blood collection needle…
- Trial name
- NCT05539846
- Testing
- modified blood collection method
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Prostate Cancer, Advanced Cancer
SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization
The investigators will study SPECT imaging of radiopharmaceutical therapies given as standard of care or as part of other compatible research protocols.
- Trial name
- (SEEtoTREAT) (NCT06389097)
- Testing
- Radium-223, 177Lu-DOTATATE, 177Lu-PSMA-617
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins