Clinical trials: Optimization
Primary Insomnia
Different Acupoints Compatibility Difference of the Effect of Treatment of the Primary Insomnia
With primary insomnia as the research object, by the method of multi-center RCT and needle single cavity and different acupoints compatibility treatment for primary insomnia, to Pittsburgh sleep quality index(PSQI) and…
- Trial name
- NCT02448602
- Testing
- acupuncture
- Where
- China
- Volunteers
- 333 people
- Sponsor
- Changchun University of Chinese Medicine
Obesity
Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women
Obesity disproportionately impacts sexual minority women. Behavioral weight loss programs are the gold standard treatment for mild to moderate obesity.
- Trial name
- NCT05775497
- Testing
- Behavioral weight loss intervention (Online; Rx Weight Loss), Minority stress intervention, Social support intervention
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- The Miriam Hospital
Heart Failure
The Optimization of Medications in Chronic Heart Failure Using a Website
Heart failure (HF) is the most common hospital discharge diagnosis among older adults in the United States. Strikingly, 2 in 5 patients are readmitted within 1-year following their first HF admission.
- Trial name
- NCT04580004
- Testing
- Med Optimization Arm
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Michigan
Lung Cancer, Head and Neck Cancer
Optimization of Smoking Cessation Strategies Concurrent With Treatment of Tobacco Related Malignancies
The purpose of this study is to find an optimal smoking cessation strategy in patients undergoing therapy for lung and head and neck cancers at selected cancer centers in Kentucky by delivering high quality smoking cessation to…
- Trial name
- NCT02048917
- Testing
- High Intensity Counseling + Long Acting NRT + PRN NRT, High Intensity Counseling + bupropion + PRN NRT, High Intensity Counseling + varenicline + PRN NRT
- Where
- 10 sites in United States
- Volunteers
- 93 people
- Sponsor
- University of Kentucky
Neoplasms, Prostate
First-Time-in-Human Study of GSK5471713 in Adults With mCRPC
This first-time-in-human study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, preliminary clinical activity, and establish the benefit/risk of GSK5471713 given as a monotherapy in mCRPC.
- Trial name
- NCT07332455
- Testing
- GSK5471713
- Where
- 20 sites in United States, Australia and 6 more
- Volunteers
- 54 people
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases, Coronary Artery Disease
Feasibility and Effectiveness of a Real-time Heart Team Approach in Complex CAD
This study is aimed to evaluate the clinical outcomes, efficiency and feasibility of the real-time heart team approach and the conventional heart team approach.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Multidisciplinary Communication
- Trial name
- EHEART (NCT05514210)
- Testing
- heart team meeting and discussion
- Where
- China
- Volunteers
- 490 people
- Sponsor
- China National Center for Cardiovascular Diseases
Asthma
Mobile Phone Text for Optimizing Asthma Treatment
The study aims at providing information on how the Short Message Service (SMS) tool influences self-management in asthma patients and to assess the resulting health related effect.
- Trial name
- NCT00917410
- Testing
- SMS support
- Where
- Denmark
- Volunteers
- 244 people
- Sponsor
- University of Copenhagen
Stress Urinary Incontinence in Women
Evaluation of Integrated Optimization Schemes for Female Stress Incontinence
The aim of this study is to determine the effectiveness of PFMT added to EA vs PFMT added sham EA for SUI in women.
- Trial name
- EIOSFSI (NCT05053373)
- Testing
- Electroacupuncture group, Pelvic floor muscle training
- Where
- 4 sites in China
- Volunteers
- 358 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Breast Neoplasms
Prevention of Female Cancers by Optimization of Selenium Levels in the Organism.
Hypothesis to be tested: Oral supplementation or diet modifications of selenium to a specified range will be effective in reducing the risk of developing cancer of any type in women with high risk of breast cancer, as compared to…
- Trial name
- SELINA (NCT04014283)
- Testing
- Diet modification
- Where
- Poland
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Read-Gene S.A.
Diabetes Mellitus, Type 2
Self Titration With Apidra to Reach Target Study (START)
Primary Objective: The primary objective of this study is to demonstrate non-inferiority of a patient-managed titration algorithm (including blood glucose monitoring) for the addition of a single dose of insulin glulisine at…
- Trial name
- NCT01013571
- Testing
- insulin glargine, Apidra (insulin glulisine)
- Where
- Canada
- Volunteers
- 493 people
- Sponsor
- Sanofi
Opioid Use, Chronic Pain
Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I
Phase 1 - MOST Preparation Phase: 1. To conduct a pilot trial at two opioid use disorder clinic sites, enrolling n=10 at both sites, for a total n=20. 2.
- Trial name
- YOGAMAT-II (NCT04646148)
- Testing
- Yoga classes
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Butler Hospital
Rheumatoid Arthritis
Applications for Methotrexate Optimization in Rheumatoid Arthritis
The goal of this study is to enable the study sponsor to assess the impact of a marketed or validated blood test has on physicians' clinical treatment decision making when treating RA patients who have been taking methotrexate.
- Trial name
- AMORA (NCT01038349)
- Testing
- Avise PG - Diagnostic test
- Volunteers
- 256 people
- Sponsor
- Cypress Bioscience, Inc.
Neuromuscular Disease
A Method to Optimize Mecanical In-exsufflation in Neuromuscular Diseases
The investigators want to demonstrate that there is an optimal expiratory pressure when using mecanical in-exsufflation for each patient in neuromuscular disease.
- Trial name
- COUGHELP (NCT02137304)
- Testing
- Cough Assist® (JH Emerson Compagny, Cambridge, MA, USA)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Breast Cancer
Design of Chatbot Persona for Breast Cancer Screening Outreach Among Black Women
Breast cancer screening disparities among Black women persist despite health system recognition and outreach. However, current evidence on how to tailor and optimize implementation strategies for breast cancer screening outreach…
- Trial name
- NCT05472064
- Testing
- Persona: Primary care doctor, Persona: Breast cancer survivor, Communication Style: Direct
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- University of Washington
Cranial Waveform in Normal Patients as a Result of Cardiac Cycle, Healthy
500 "Normal" Adult Subjects Who Have Experienced no Known Brain Injury Will Participate in Collecting Data That Will Assist With the Optimization of the Diagnostic Capabilities of the Harmony in Detecting Neurologic Abnormalities.
The REFRESH study is designed to collect data related to a signal in the brain that MindRhythm has named the Headpulse. The Headpulse occurs as a natural movement of the brain in conjunction with the beating of the heart.
- Trial name
- REFRESH (NCT05203393)
- Testing
- Harmony Headset
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- MindRhythm, Inc.
Attention-Deficit/Hyperactivity Disorder
Tolerability and Efficacy of AM and PM Once Daily Dosing With Extended-release Guanfacine Hydrochloride in Children 6-12 With Attention-Deficit/Hyperactivity Disorder (ADHD) (The ADHD Tempo Study)
The primary purpose is to assess the efficacy of once daily dosing with optimized SPD503 (1, 2, 3 and 4mg/day), dosed either in the morning or evening, compared to placebo, in children with ADHD as measured by change from…
- Trial name
- NCT00997984
- Testing
- extended-release guanfacine hydrochloride (SPD503), extended-release guanfacine hydrochloride
- Where
- 46 sites in United States, Canada
- Volunteers
- 340 people
- Sponsor
- Shire
Childhood Obesity
An Evaluation of a Web-based System for Optimization of Behavioral Childhood Obesity Treatment
This study evaluates the families' and health care professional's experience from using a web based support system including mobile applications for self-monitoring weight and physical activity.
- Trial name
- NCT03380598
- Testing
- CLOSS, Usual care
- Where
- 3 sites in Sweden
- Volunteers
- 28 people
- Sponsor
- Karolinska Institutet
Chronic Obstructive Pulmonary Disease (COPD)
Assessing and Improving Misuse of Inhalers in COPD Outpatients
Chronic obstructive pulmonary disease (COPD) is a common long-term lung disease that causes breathlessness, cough, and frequent flare-ups. Most patients with COPD use inhaled medications every day.
- Trial name
- AIMO COPD (NCT07264140)
- Testing
- Physiotherapist-Led Inhaler Optimization Program
- Where
- Switzerland
- Volunteers
- 116 people
- Sponsor
- Hôpital Fribourgeois
Heart Failure, Left Bundle-Branch Block
Resynchronization in Paced Heart Failure Patients With Implantable Cardioverter Defibrillator (ICD) Indication
Today patients with a Cardiac Resynchronization Therapy (CRT) indication usually receive 2 ventricular leads, right ventricular (RV) apex and left ventricular (LV) (postero-) lateral, gaining a responder rate of approximately…
- Trial name
- CRTICD Dual LV (NCT01415024)
- Testing
- second LV lead in CRT
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Schuechtermann-Klinik
Type 1 Diabetes Mellitus
Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas
BACKGROUND. Optimal glucose control can prevent/relent tissue damage in patients with type 1 diabetes mellitus (T1DM). Ongoing efforts aim at developing closed loop control (CLC) algorithms linking subcutaneous continuous glucose…
- Trial name
- NCT02003274
- Testing
- Clamp-Mixed Meal, IVGTT-Mixed Meal Arm
- Where
- 2 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona