Clinical trials: Optimized Treatment
Stage II, III, Nasopharyngeal Squamous Cell Carcinoma
Optimized Treatment Strategies for Early and Medium Stage Nasopharyngeal Carcinoma
The purpose of this study is to optimize treatment strategies for patients with stage II and III nasopharyngeal carcinoma, reduce the side effects related to treatment and improve the quality of life.
- Conditions
- Stage II, III, Nasopharyngeal Squamous Cell Carcinoma, Induction Chemotheray, Concurrent Chemoradiotherapy
- Trial name
- NCT03908372
- Testing
- Docetaxel, Cisplatin, IMRT
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Skin Laxity
The INFORM Study: Rotational Fractional Resection for Submental Contouring
Efficacy and safety of Rotational Fractional Resection (skin resection) in patients with moderate to severe submental skin laxity.
- Trial name
- NCT03853980
- Testing
- Focal Contouring System
- Where
- 14 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Recros Medica, Inc.
Reducing Tuberculosis Incidence
DeMONSTRATE-TB Study in Ethiopia
Ending the TB epidemic by 2035 in Ethiopia would be possible if TB notification declines by an annual factor of at least 15% from the current notification rate of 132 per 100,000 population.
- Trial name
- NCT06719193
- Testing
- Enhanced community-wide TB intervention, Routine TB program activities
- Where
- 2 sites in Ethiopia
- Volunteers
- 131,438 people, healthy volunteers welcome
- Sponsor
- Management Sciences for Health
Hypertension
Pragmatic Trial Comparing Telehealth Care and Optimized Clinic-Based Care for Uncontrolled High Blood Pressure
This pragmatic trial will compare two team-based care models for managing hypertension, Best Practice Clinic-based Care and Telehealth Care with pharmacist management, in a large care system in Minnesota.
- Trial name
- NCT02996565
- Testing
- Best Practice Clinic-Based Care, Telehealth Care
- Where
- United States
- Volunteers
- 3,071 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Frown Lines, Glabellar Frown Lines
Study Evaluating the Treatment of Forehead and/or Glabellar Lines With the CRYO-TOUCH III Device
myoscience Inc. (Redwood City, CA) has developed a device for a novel, minimally invasive facial rejuvenation procedure designed to soften hyperdynamic facial lines.
- Trial name
- NCT01808742
- Testing
- Treatment with CryoTouch III Device
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Obesity
Elements Vital to Treat Obesity Study
The overall objective of this study is to evaluate the first rigorously optimized, remotely delivered treatment for obesity against the current gold standard treatment in a head-to-head randomized controlled trial.
- Trial name
- EVO (NCT04708769)
- Testing
- Smartphone App Participants (APP), Diabetes Prevention Program Participants (DPP)
- Where
- United States
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Frown Lines, Glabellar Frown Lines
A Prospective Study Evaluating the Treatment of Forehead and/or Glabellar Lines With the Cryo-Touch IV Device
myoscience Inc. (Redwood City, CA) has developed a device for a novel, minimally invasive facial rejuvenation procedure designed to soften hyperdynamic facial lines.
- Trial name
- NCT01801826
- Testing
- Treatment with CryoTouch IV
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Major Depressive Disorder
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of this study is to integrate clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome…
- Trial name
- CAN-BIND-17 (NCT05017311)
- Testing
- Escitalopram, Brexpiprazole
- Where
- 10 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Healthy
A Study of the Cardiac Effects of ALXN1840 in Healthy Adults
This study will evaluate the effect of a supratherapeutic dose of ALXN1840 on the heart rate (HR)-corrected QT interval (QTc) in healthy adult participants. Moxifloxacin will be used as the active control.
- Trial name
- NCT04560816
- Testing
- ALXN1840, Moxifloxacin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Vocal Cord Injuries
in Vitro Evaluation of the Anti-fibrotic Activity of Adipose Tissu-derived Stromal Vascular Fraction Used as a Medicinal Treatment for Scarred Vocal Folds
This is a single-center, prospective study, aimed at investigating the anti-fibrotic in vitro activity of the stromal vascular fraction of patients with scarred vocal cord.
- Trial name
- CELLCORDES BIO (NCT06823908)
- Testing
- Reuse of surgical waste, Reuse of biological samples
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Major Depressive Disorder
Comparing Efficacy of Optimal Treatment and Conventional Treatment for Major Depressive Disorder in Viet Nam
Comparison of efficacy treatment (respond, remission) between the optimized treatment group (dose adjustment or early change other drug based on the change of total score HAM-D 17) and the routine treatment group (start with the…
- Trial name
- NCT04826614
- Testing
- optimized treatment
- Where
- Vietnam
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Hemorrhage, Hemodynamic Instability
Consortium for Optimized Integration of Bio-Artificial Blood Components for Adaptive Resuscitation Therapy
There is need for a whole blood analog for use when banked blood is unavailable or undesirable. In civilian trauma, hemorrhage accounts for ~ 35% of pre-hospital deaths; moreover, ~ 20% of military casualties are in hemorrhagic…
- Trial name
- CONCERT (NCT05756426)
- Testing
- Prospective
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Myopia, Astigmatism
Wavefront-guided Versus Wavefront-optimized LASIK for Nearsightedness
The purpose of the study is to compare the results of LASIK surgery when using wavefront-guided excimer laser treatment compared to wavefront optimized excimer laser treatment in patients with nearsightedness with and without…
- Trial name
- NCT01138189
- Testing
- Wavefront-guided LASIK, Wavefront-optimized LASIK
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Edward E. Manche