Clinical trials: Oral Biofilm
Halitosis
Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis
Purpose: To investigate the short-term clinical effect of curcumin-containing toothpaste on halitosis as compared to placebo and to assess potential shifts in the composition of dental biofilm associated with the use of…
- Trial name
- NCT04998617
- Testing
- Toothpaste with curcumin, Toothpaste without curcumin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Oral Leukoplakia
Candida Associated Cytokines in Oral Leukoplakia
This study aims to determine the correlation between candida and pro- inflammatory cytokines response in Oral Leukoplakia(OL) with antifungal therapy.
- Trial name
- NCT04712929
- Testing
- Fluconazole
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Gingivitis, Dental Plaque
Effectiveness of Salvadora Persica Miswak in Improving Plaque Control and Gingival Health
Dental plaque is a main etiologic agent in periodontal disease. Global of Burden Disease Study 2016 ranked periodontal disease as the 11th most prevalent disease affecting 10.5% population worldwide.
- Trial name
- NCT04650685
- Testing
- The novel Salvadora persica toothbrush, The Salvadora persica (miswak) chewing stick, Standard toothbrush and toothpaste (control)
- Where
- Malaysia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Dental Diseases
Investigation of Bacterial Adhesion and Bactericide Effect ex Vivo on Different Implant Restoration Materials
Investigation of bacterial adhesion and bactericide effect ex vivo on different implant restoration materials
- Trial name
- NCT04657757
- Testing
- Intraoral apparatus
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Gingivitis
Frankincense and Herbal Extracts for Plaque-Induced Gingivitis: A Double-Blind RCT
Frankincense, a natural resin obtained from trees of the Boswellia genus, has been traditionally used for its medicinal properties.
- Trial name
- FHEPIG (NCT07535229)
- Testing
- Frankinscence and coconut Oil based mouthwash, Frankinscence and Thyme essence/ water based mouthwash, Chlorhexidine (0.2%)
- Where
- Oman
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Oman Dental College
Gingivitis
Efficacy of Matcha Tea on Patients With Biofilm-induced Gingivitis
1. Evaluate the salivary level of antioxidants (malondialdehyde "MDA," superoxide dismutase "SOD," and glutathione peroxidase-1 "GPX-1") by enzyme-linked immunosorbent assay test (ELISA). 2.
- Trial name
- NCT06912958
- Testing
- Drinking of matcha tea, Organic Japanese Matcha, Jade Leaf, Japan
- Where
- Iraq
- Volunteers
- 50 people
- Sponsor
- Ahmed Talib
Mouth Diseases
Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene
The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days.
- Trial name
- NCT02913235
- Testing
- Oral hygiene discontinuation group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gingivitis, Dental Plaque
MicroRepair® ABX vs Chlorhexidine 0.12% in Gingivitis Patients
This randomized controlled clinical trial is designed to compare the adjunctive effects of two mouthwashes used after professional biofilm removal in patients with generalized plaque-induced gingivitis, a reversible inflammatory…
- Conditions
- Gingivitis, Dental Plaque, Gingival Inflammation
- Trial name
- GEM-CHX012 (NCT07088653)
- Testing
- MicroRepair ABX mouthwash, Chlorhexidine 0.12% mouthwash
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Oral Health
Quaternary Ammonium Methacryloxy Silicate-containing Acrylic Resin
One of the major challenges in orthodontic treatment is long-term stability. Because removable retainers are worn for at least one year, bacteria and fungi may accumulate on the retainers in the form of multi-species plaque…
- Trial name
- NCT02525458
- Testing
- QAMS-containing PMMA, QAMS-free PMMA
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Frank Tay, BDSc (Hons), PhD
Peri-implantitis, Dental Implants
Natural Bioactive Gel for Peri-Implantitis
This study is a randomized controlled clinical trial using a split-mouth design to evaluate the effectiveness of a natural bioactive gel (Sterify Gel®) as an adjunct to standard non-surgical therapy for peri-implantitis.
- Conditions
- Peri-implantitis, Dental Implants, Non-surgical Periodontal Therapy
- Trial name
- PERISTER (NCT07088679)
- Testing
- Sterify Gel (mucoadhesive bioactive gel), Standard Non-Surgical Peri-Implantitis Therapy
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Pavia
Peri-Implantitis
Efficacy of Er: YSGG Laser in Treatment of Peri-implantitis
This study will be carried out to evaluate the efficacy of Er: YSGG laser on oral biofilm removal from implant surface in various peri-implant defect morphology in the treatment of peri-implantitis as a primary objective.
- Trial name
- NCT05137821
- Testing
- Er: YSGG laser, no therapy
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontal Diseases
Antibacterial and Anti-biofilm Activity of Frankincense Extract Against Porphyromonas Gingivalis
Boswellia sacra Flueck. oleoresin extract (frankincense) was traditionally used in the treatment of different diseases as respiratory, rheumatoid arthritis, and bacterial infections.
- Trial name
- NCT04705714
- Testing
- Frankincense Extract
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Poly(Lactide-co-glycolide) Sutures, Suture Resorption
Comparative Analysis of fast-and Slow-absorbable Poly(Lactose-co-glycolide) Sutures in Oral Surgery: a Randomized Controlled Trial.
This study aims to compare slow-resorbing and fast-resorbing sutures used after the surgical extraction of lower third molars. Sutures are routinely placed after wisdom tooth removal to promote hemostasis.
- Conditions
- Poly(Lactide-co-glycolide) Sutures, Suture Resorption, Third Molar Surgery
- Trial name
- NCT07498361
- Testing
- Fast absorbable sutures application, Standard absorbable sutures application
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Padova, School of Dental Medicine
Oral Disease
Effect of Different Cleaning Regimes on Biofilm Formation of Acrylic Based Removable Orthodontic Appliance
This study is to evaluate the effects of different cleaning regimes i.e. chemical and mechanical on biofilm formation of an acrylic based removable orthodontic appliance and to find out if surface modification i.e.
- Trial name
- NCT05707221
- Testing
- cleaning removable acrylic appliance with denture brush and chlorhexidine toothpaste, cleaning removable acrylic appliance with cleansing tablet, combination of mechanical and chemical cleaning
- Where
- Iraq
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Gingivitis and Periodontal Diseases, Gingivitis; Chronic
Guided Biofilm Therapy Compared to Traditional Cleaning for Treating Gingival Inflammation in Orthodontic Patients
Why is this study being done? This study is for people with braces who have gum inflammation (gingivitis), which is when gums are swollen and bleed easily.
- Conditions
- Gingivitis and Periodontal Diseases, Gingivitis; Chronic, Gingivitis, Gingival Bleeding
- Trial name
- NCT07355517
- Testing
- Guided Biofilm Therapy, Traditional Ultrasonic Scaling + Polishing
- Where
- Jordan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Gingivitis
Mouthwash of Pomegranate Against Biofilm and Gingival Inflammation in School Children
The mechanical control of supragingival biofilm is accepted as one of the most important measures to prevent dental caries and periodontal diseases. Nevertheless, maintaining dental surfaces biofilm-free is not an easy task.
- Trial name
- NCT02949583
- Testing
- Punica granatum Linn., chlorhexidine
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- Universidade Estadual da Paraiba
Gingivitis
Anti-Inflammatory Efficacy of Ginger Containing Dentifrice in the Control of Biofilm Induced Gingivitis
The goal of this clinical trial is to test efficiency of using toothpaste containing (Ginger) over a period of three month to control on gingival inflammation and plaque accumulation through measuring the clinical periodontal…
- Trial name
- NCT05868200
- Testing
- Capitano zenzero toothpaste, Colgate total toothpaste
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Apical Periodontitis, Endodontic Disease
Nanozymes in Endodontics
The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment.
- Conditions
- Apical Periodontitis, Endodontic Disease, Root Canal Infection
- Trial name
- NCT07518901
- Testing
- Nanozyme treatment, Control (Standard treatment)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pennsylvania
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study
Snuff use and smoking associated with poor periodontal health, especially if used together.
- Trial name
- NCT03614871
- Testing
- Epidemiological study
- Volunteers
- 1,676 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Oral Biofilm, Periodontitis
Methodology Antiseptic Application, Influence on Oral Biofilm.
The study has the objective to compare two different methodology of application the antiseptic on the oral biofilm will be formed during 48h in situ on a specific device.
- Conditions
- Oral Biofilm, Periodontitis, Gingivitis
- Trial name
- NCT02267239
- Testing
- essential oils, immersion, Chlorhexidine, immersion, essential oils, mouthwash
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela