Clinical trials: Oral Cavity Cancer
Oral Cancer
Analysis Of Sensory Recovery Of Donor Size And Quality Life In Oral Cancer Patients
The aim of the study is to investigate post-surgery sensory impairment and life quality changes in oral cancer patients who underwent free flap (Free Flap) on post-operative 6 months, 12 months, and 24 months, respectively
- Trial name
- NCT02048631
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Oral Cancer, Esophageal Cancer
Evaluations of Alcohol Warning Labels
The goal of this study is to determine the effectiveness of pictorial warning labels (PWLs) featuring narrative (vs. non-narrative) content in communicating the cancer risk of alcohol.
- Conditions
- Oral Cancer, Esophageal Cancer, Larynx Cancer, Alcohol Drinking
- Trial name
- NCT06129487
- Testing
- Narrative pictorial warning labels for alcoholic beverages, Non-narrative pictorial warning labels for alcoholic beverages
- Where
- United States
- Volunteers
- 1,053 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Non Small Cell Lung Cancer
TGRX-326 Pharmacokinetic Drug Interaction
This is a drug-drug interaction study for TGRX-326 to evaluate the effects of CYP3A inhibitor/inducer drugs on pharmacokinetic profiles of TGRX-326, an ALK inhibitor indicated for treatment of Non-small cell lung cancer.
- Trial name
- NCT06294561
- Testing
- Itraconazole+TGRX-326, Efavirenz+TGRX-326
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Shenzhen TargetRx Co., Ltd.
Gastric Cancer, Colorectal Cancer
Oral, Fecal and Intratumoral Microbiome Atlas in Colombian Patients With Advanced Solid Tumors Receiving First-Line Immunotherapy
This is a prospective observational cohort study conducted at Fundación CTIC in Bogotá, Colombia. It characterizes the oral, fecal and intratumoral microbiome of Colombian adults with advanced solid tumors (gastric, colorectal…
- Conditions
- Gastric Cancer, Colorectal Cancer, Breast Cancer, Cervical Cancer
- Trial name
- ATLAS (NCT07676461)
- Testing
- First-line immunotherapy (immune checkpoint inhibitors), INVIMA-approved, standard of care
- Where
- Colombia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Basal Cell Carcinoma
Vismodegib for Treatment of Basal Cell Carcinoma
The primary objectives of this study are to assess, using Mohs micrographic surgery (MMS) at the end of treatment, the efficacy (primary) and safety (secondary) of vismodegib compared to placebo in the oral adjunctive pre…
- Trial name
- Erivedge (NCT01543581)
- Testing
- Vismodegib
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abel Torres, MD
Oral Cancer Screening
Non-invasive Methods for Oral Cancer Screening
Oral cancer is a common cancer worldwide, with approximately 250,000 new cases annually and a high mortality rate. Its major risk factors include smoking, alcohol consumption, and betel nut chewing.
- Trial name
- HRME (NCT07249437)
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders
Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer Triage
This research study evaluates an experimental, point-of-care tool that combines Deep Ultraviolet (DUV) light imaging with Artificial Intelligence (AI) to rapidly screen for oral cancer and pre-cancer (dysplasia).
- Conditions
- Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Cancer
- Trial name
- DEEP UV-M (NCT07842211)
- Testing
- Deep UV-M and AI Cytology Triage
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Anh Le
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Liver Cancer
Prevention for the Development of Liver Tumorigenesis by the Oral Supplementation of Branched-chain Amino Acids
The long-term outcomes of branched-chain amino acid (BCAA) administration in patients undergoing hepatic resection remain unclear.
- Trial name
- NCT01434524
- Testing
- LIVACT
- Where
- Japan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kochi University
Oral Cancer, Oral Cavity Cancer
WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMA
Cancer of the oral mucosa, also known as oral squamous cell carcinoma (OSCC), occurs as an ulceroproliferative lesion that can develop at any site in the mouth, from the lips to oropharynx.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Squamous Cell Carcinoma
- Trial name
- NCT05927220
- Testing
- Biopsy Specimens Histopathology
- Where
- Pakistan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Pathology Rawalpindi
Neuroblastoma
A Study of a Vaccine in Combination With β-glucan and GM-CSF in People With Neuroblastoma
The purpose of the study is to explore the combination of a bivalent vaccine, a sugar called beta-glucan (β-glucan), and a protein called granulocyte-macrophage colony stimulating factor (GM-CSF) as an effective treatment for…
- Trial name
- NCT04936529
- Testing
- β-glucan, GM-CSF, OPT-821
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Parotid Neoplasms
Feasibility Study of MRI Imaging on Parotid Gland Stimulation
The aim of this study is to determine the feasibility of demonstrating the following physiologically-descriptive quantities ('metrics'): the volume of plasma/volume of tissue (νp), Apparent Diffusion Coefficient (ADC), the volume…
- Trial name
- SPIT (NCT02294838)
- Testing
- MRI, Citric acid, Gadovist
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Lipid Profile, Lipids
Serum Lipid Profile and Lip Squamous Cell Carcinoma
The goal of this observational retrospective study is to assess whether serum lipid levels differ between patients diagnosed with lip squamous cell carcinoma (SCC) and healthy individuals.
- Conditions
- Lipid Profile, Lipids, SCC - Squamous Cell Carcinoma, Lip Cancer
- Trial name
- NCT07005115
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Chemotherapy-Induced Neutropenia
Study to Evaluate the Safety, Tolerability and PK of EC-18 After Oral Administration in Healthy Volunteers
This study is a Dose block-randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Escalation, Phase I clinical trial to assess the safety, tolerability and pharmacokinetics of single-dose and…
- Trial name
- NCT02532712
- Testing
- EC-18
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Enzychem Lifesciences Corporation
Oral Health, Oral Cancer
The Use of Functional Confections in Promoting Oral Health
In areas of the world where populations are undernourished poor oral health is prevalent. Diets rich in fruit and vegetables are thought to have many health benefits including reducing the risk of oral cancer or gum disease.
- Conditions
- Oral Health, Oral Cancer, Gum Disease
- Trial name
- NCT01514552
- Testing
- Strawberry gummy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cancer
A Bioavailability Study of Nilotinib in Healthy, Adult, Human Subjects Under Fasted Conditions.
An open label, single-center, balanced, randomized, four-treatment, four-sequence, four-period, single dose, crossover, comparative bioavailability study in healthy, adult, human subjects under fasteding conditions
- Trial name
- XS003-11 (NCT07138378)
- Testing
- XS003 (nilotinib), Tasigna (nilotinib)
- Where
- India
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xspray Pharma AB
Pelvic Cancer, Enteritis, Probiotics,Chemoradiotherapy
Oral Probiotics on Radiation Enteritis Stage Ⅱ Induced by Pelvic Concurrent Chemoradiotherapy
Effect of Probiotics on Raditon Enteritis in Pelvic Tumor Patients Receiving Radiotherapy.
- Trial name
- probiotics (NCT05032027)
- Testing
- probiotics
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jiangxi Provincial Cancer Hospital
Oral Squamous Cell Carcinoma
Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma
This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions)…
- Trial name
- NCT05821179
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Head and Neck Cancer
Biomarkers in Patients With Head and Neck Cancer and in Healthy Volunteers
RATIONALE: Studying samples of blood, tissue, and saliva in the laboratory from patients with cancer and from healthy volunteers may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT00899769
- Testing
- protein expression analysis, proteomic profiling, immunoenzyme technique
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center