Clinical trials: Oral Cavity Disease
Dental Caries, Periodontal Diseases
Biomimetic Hydroxyapatite in Pediatric Patients With Asthma and/or Allergic Rhinitis
The aim of the study is to compare the incidence of dental caries and the level of demineralization in pediatric patients with asthma and/or allergic rhinitis. Patients will conduct professional oral hygiene at the baseline.
- Trial name
- NCT05631197
- Testing
- Biorepair Total Protection Plus + desensitizing enamel-repair shock treatment, Sensodyne Repair & Protect
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Stage III Oropharyngeal Squamous Cell Carcinoma, Stage IVA Oropharyngeal Squamous Cell Carcinoma
Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer
This randomized phase II trial studies the side effects and how well modestly reduced-dose intensity-modulated radiation therapy (IMRT) with or without cisplatin works in treating patients with oropharyngeal cancer that has…
- Conditions
- Stage III Oropharyngeal Squamous Cell Carcinoma, Stage IVA Oropharyngeal Squamous Cell Carcinoma, Stage IVB Oropharyngeal Squamous Cell Carcinoma, Stage IVC Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT02254278
- Testing
- Cisplatin, IMRT 6 weeks, IMRT 5 weeks
- Where
- 222 sites in United States, Canada and 2 more
- Volunteers
- 316 people
- Sponsor
- NRG Oncology
Gingivitis
Iranian Traditional Mouth Rinse Punica Granatum Pleniflora (Golnaar) in Treatment of Gingivitis in Diabetic Patients
This is a triple-blinded randomized clinical trial to evaluate the effect of an Iranian traditional mouth rinse (Punica granatum Pleniflora or "Golnaar" mouthrinse) on treatment of diabetic gingivitis and compare it with…
- Trial name
- Golnaar (NCT02227485)
- Testing
- Punica granatum Pleniflora (Golnaar) mouth rinse, Chlorhexidine (0.2%), Tooth bleaching
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shiraz University of Medical Sciences
Periodontitis
''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis
Hyaluronic Acid (HA) is an addition to the local chemotherapeutic agents. Hyaluronic acid was discovered by Meyer and Palmer. HA is widely found in the extracellular matrix and it plays an essential role in controlling cell…
- Trial name
- NCT05834517
- Testing
- Hyaluronic acid, non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Ehab Haider Hassan El-emam
Major Salivary Gland Carcinoma, Minor Salivary Gland Carcinoma
Nivolumab and Ipilimumab in Treating Patients With Metastatic/Recurrent ACC of All Sites and Non-ACC Salivary Gland Cancer
This phase II trial studies the efficacy (the effect on the tumor) and the safety (the effect on the body) of the study drugs when given as a combination in participants with this type of cancer.
- Conditions
- Major Salivary Gland Carcinoma, Minor Salivary Gland Carcinoma, Recurrent Salivary Gland Carcinoma, Stage IV Major Salivary Gland Carcinoma
- Trial name
- NCT03146650
- Testing
- Ipilimumab, Laboratory Biomarker Analysis, Nivolumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Periodontitis, Dry Eye Disease (DED)
Association Between Periodontitis and Dry Eye Disease: A Cross-Sectional Study
This study is aiming at exploring the association between periodontitis and dry eye disease, which are both chronic inflammatory diseases that might have common pathogenic mechanisms.
- Trial name
- NCT07873697
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Behçet's Syndrome
A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behçet's Disease
The main objective of this study is to evaluate the efficacy and safety of apremilast in the treatment of oral ulcers in adults with active Behçet's disease (BD).
- Trial name
- NCT02307513
- Testing
- Apremilast
- Where
- 63 sites in United States, France and 8 more
- Volunteers
- 207 people
- Sponsor
- Amgen
Sjogren's Syndrome
Ultra-High Frequency Ultrasonography in Sjögren's Syndrome
Patients diagnosed with a diagnosis of Sjogren's syndrome performed according to the ACR/EULAR criteria will be included in the study.
- Trial name
- UltraSjögren (NCT06338735)
- Testing
- Ultra-High Frequency Ultrasound scan of minor salivary glands
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Pisa
Asthma, Aspirin-Induced
Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD)
The purpose of this phase 2 study is to assess the safety and efficacy of oral ifetroban for the treatment of aspirin-exacerbated respiratory disease (AERD).
- Trial name
- NCT03028350
- Testing
- Ifetroban Oral Capsule
- Where
- 16 sites in United States
- Volunteers
- 54 people
- Sponsor
- Cumberland Pharmaceuticals
Bone Loss, Alveolar
L-PRF in Alveolar Ridge Preservation
The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate.
- Trial name
- L-PRF (NCT03408418)
- Testing
- Platelet-rich fibrin
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Peri-implant Mucositis, Mucositis Oral
Treatment of Peri-implant Mucositis by Sodium Hypochlorite Gel and Cross-linked Hyaluronic Acid Gel
The aim of the study is to evaluate the potential of the combination of a sodium hypochlorite-based gel and a hyaluronic acid-based gel as an adjuvant to Non-Surgical Mechanical Debridement (NSMD) in the treatment of mucositis…
- Trial name
- NCT05926297
- Testing
- Application NaOCl gel + HA gel, Non-surgical mechanical debridement
- Where
- 2 sites in Hungary, Italy
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Federico II University
Facial Paralysis, Central, Stroke
Mimic Muscle Volume, Central Facial Palsy Severity and Dysphagia
70 stroke patients with central facial paralysis will be included and their demographic data will be questioned and facial nerve thickness, depressor labi inferior, depressor anguli oris, buccinator and risorius muscles will be…
- Trial name
- NCT06615297
- Testing
- ultrasonographic evaluation
- Volunteers
- 70 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Furcation Defects
Surgical Treatment of Mandibular Furcations Using a Xenograft With/Without a Collagen Membrane
The aim of the study was to perform a randomized controlled clinical study in order to compare the effects of a bovine derived xenograft (with 10% collagen) + a bioabsorbable membrane (control group, CG) vs a bovine derived…
- Trial name
- NCT03354182
- Testing
- Open flap surgery, Bio-oss collagen, Bio-gide
- Volunteers
- 19 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Edentulous Jaw
Comparing Marginal Bone Loss for Immediately Loaded Implants in Maxillary Full Arch Interim Prosthesis Using Welded Titanium Bar Versus Polyetheretherketone Bar
Fourteen completely edentulous patients will be randomly allocated into two parallel arm groups. For both groups virtual implant planning will be done and surgical guide will be planned and printed.
- Trial name
- NCT06127017
- Testing
- splinting dental implants with titanium bar, splinting dental implants with PEEK bar
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Recurrent Aphthous Stomatitis, Oral Ulcers
Efficacy of 5% Chitosan Nanoparticle Paste in the Treatment of Recurrent Aphthous Stomatitis
The purpose of this study is to evaluate the therapeutic clinical efficacy of a synthesized 5 wt.% chitosan nanoparticle paste compared to a standard topical corticosteroid (triamcinolone acetonide 0.1% oral paste) in patients…
- Trial name
- NCT07702474
- Testing
- Triamcinolone Acetonide 0.1% Oral Paste, 5 wt.% Chitosan Nanoparticle Paste
- Volunteers
- 30 people
- Sponsor
- Kerman University of Medical Sciences
Anemia, Non-Dialysis-Dependent Chronic Kidney Disease
Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)
A multicenter, randomized, open-label, active-controlled Phase 3 study for the maintenance treatment of anemia in participants with Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)
- Trial name
- NCT02680574
- Testing
- Vadadustat, Darbepoetin alfa
- Where
- 503 sites in United States, Argentina and 28 more
- Volunteers
- 1,725 people
- Sponsor
- Akebia Therapeutics
Polycystic Kidney, Type 1 Autosomal Dominant Disease, Polycystic Kidney, Type 2 Autosomal Dominant Disease
Pulsed Oral Sirolimus in Autosomal Dominant Polycystic Kidney Disease
Sirolimus (SIR) has lead to a reduction of overall kidney size, a decrease in cyst density and general tubular cell proliferation in animal models, and to a reduction of the increase in creatinine and blood urea nitrogen by 34…
- Trial name
- RAP (NCT02055079)
- Testing
- Sirolimus
- Where
- Austria
- Volunteers
- 68 people
- Sponsor
- Medical University of Vienna
Recurrent Aphthous Stomatitis
A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis
This is a randomized, double blind, placebo controlled trial of the use of pentoxifylline (oxpentifylline) for the treatment of recurrent mouth ulcers.
- Trial name
- NCT00315679
- Testing
- Pentoxifylline (also known as oxpentifylline)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Apical Periodontitis
Comparison of AH Plus and WellRootST Root Canal Sealers in Terms of Postoperative Pain: One-Month Follow-up
This randomized, parallel-group clinical trial aimed to compare the effects of two root canal sealers, AH Plus and Well-Root ST, on postoperative pain in patients undergoing single-visit root canal treatment for teeth diagnosed…
- Trial name
- NCT07246174
- Testing
- AH Plus Root Canal Sealer, Well-Root ST Root Canal Sealer
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Medipol University
Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection
Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial
The goal of this clinical trial is to learn if a new combination antibiotic treatment (Arm D) works to treat a rare lung condition called mycobacterium abscessus pulmonary disease in people of any age and sex, when compared to…
- Conditions
- Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection, Non-Tuberculous Mycobacterial (NTM) Infections, Non-Tuberculous Mycobacteria Pulmonary Disease
- Trial name
- FORMaT-EVOLVE (NCT07485010)
- Testing
- Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin
- Volunteers
- 300 people
- Sponsor
- The University of Queensland
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