Clinical trials: Oral Cavity Disease
Cleft Lip and Palate
Use of Computer Aided Design and 3D Printing for Anesthesiology Management in a Pediatric Patient With Cleft Facial Defect (3D Obturator) - Pilot Trial
Congenital malformations of the orofacial area are the most common congenital malformations in children with an incidence of 1.8 children with orofacial cleft per 1000 healthy births in the Czech Republic.
- Trial name
- Pilobtur (NCT04422964)
- Testing
- 3D Obturator
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Brno University Hospital
Alveolar Bone Loss
Evaluation of Short Implants' Success for Teeth Replacement in Atrophic Posterior Mandibular Ridge
The aim of this study was to evaluate clinically and radiographically the splinted short implants' and single short implants' stability and bone condition before and after loading, in atrophic posterior mandibular alveolar ridges.
- Trial name
- NCT04414709
- Testing
- Double short implant, Single short implant
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Alexandria University
Trigeminal Neuralgia
Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program
Background: Prognosis of medically treated trigeminal neuralgia patients is assumed to be poor, but the evidence is lacking. Thus, prospective real-life studies of medical management of trigeminal neuralgia are warranted.
- Trial name
- NCT03838393
- Testing
- multidisciplinary management
- Volunteers
- 186 people
- Sponsor
- Danish Headache Center
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Behcet's Disease
Anti IL-18 (GSK1070806) in Behcet's Disease
The primary outcome measure of the study is to demonstrate the safety and tolerability of GSK1070806 in the Behcet's disease population at 24 weeks, with biochemical and clinical efficacy and mechanistic studies to further…
- Trial name
- NCT03522662
- Testing
- GSK1070806
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Periodontitis
Human Dental Pulp Mesenchymal Stem Cells for the Treatment of Chronic Periodontitis Patients
The primary objective:To evaluate the efficacy of different administration protocols of human dental pulp mesenchymal stem cells for the treatment of chronic periodontitis patients.
- Trial name
- NCT05924373
- Testing
- Human Dental Fulp Stem Cells
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Peking University Third Hospital
Gingivitis, Supragingival Plaque
Evaluation of the Efficacy and Safety of a Loop Stretchable Dental Floss
This will be a single-blind, single-center, parallel, randomized controlled clinical trial to evaluate the efficacy and safety of Floss Loops stretchable floss for the control of gingivitis and supragingival plaque removal…
- Trial name
- NCT06515483
- Testing
- Brushing and Flossing of teeth, Brushing Only
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Indiana University
RADICULAR CYSTS
Radicular Cyst Enucleation Using Piezosurgery Versus Conventional Surgery
AIM: The study was intended to evaluate the effectiveness of piezosurgery in enucleation of radicular odontogenic cysts in comparison to the conventional technique from both the clinical and radiographic perspectives.
- Trial name
- NCT04244422
- Testing
- PIEZOSURGERY VERSUS CONVENTIONAL SURGERY
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Burning Mouth Syndrome
The Efficacy of N-acetyl-cysteine in the Treatment of Burning Mouth Syndrome
The purpose of this study was to examine the efficacy of N-acetyl cysteine in the treatment of burning mouth syndrome. A control group of patients with burning mouth syndrome will receive a placebo.
- Trial name
- NCT05309070
- Testing
- N-acetyl cysteine
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- University of Zagreb
Apical Periodontitis
Assessment of Different Disinfection Protocols on Regenerative Potential of Mature Teeth
Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis.
- Trial name
- NCT05557994
- Testing
- Method
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Minia University
Periodontal Disease
Photodynamic Lasertherapy (PDT) in Periodontal Treatment (in Vivo)
The purpose of the study is to evaluate the effect of the photodynamic therapy in periodontal patients
- Trial name
- NCT00196456
- Testing
- photosensitisation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Periodontitis
Accuracy of Artificial Intelligence-Assisted Staging and Grading for Diagnosis of Periodontitis.
This observational study aims to develop and assess the accuracy, specificity, and sensitivity of a deep learning model for the classification of periodontitis using panoramic radiographs and clinical data inputs.
- Trial name
- NCT07113327
- Testing
- Artificial Intelligence-Assisted Staging and Grading for Diagnosis of Periodontitis
- Where
- Egypt
- Volunteers
- 47 people
- Sponsor
- Ain Shams University
Systemic Lupus Erthematosus, Systemic Sclerosis (SSc)
Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Autoimmune Diseases
Autoimmune diseases refer to a common category of diseases caused by the immune system reacting to self-antigens, leading to tissue damage.
- Conditions
- Systemic Lupus Erthematosus, Systemic Sclerosis (SSc), Sjogren Syndrome, ANCA Associated Vasculitis (AAV)
- Trial name
- NCT06828042
- Testing
- anti-CD19 CAR T cell therapy
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Generalized Chronic Periodontitis
Activated MMP-8 as Diagnostic Test for Periodontitis
Background: Untreated periodontal disease may influence general health. However, how may a physician who is not trained in periodontal probing detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in…
- Trial name
- MMP-8 (NCT02280122)
- Testing
- no intervention provided
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Goethe University
Periodontal Bone Loss, Periodontal Defect
Polynucleotides and Hyaluronic Acid vs Enamel Matrix Proteins in the Treatment of Intrabony Defects
The goal of this clinical trial is to compare two periodontal regenerative treatments in adults with Stage III or IV periodontitis and infrabony periodontal defects ≥3 mm.
- Conditions
- Periodontal Bone Loss, Periodontal Defect, Periodontitis Stage III, Periodontitis Stage IV
- Trial name
- PN-HAVSEMPIND (NCT07589959)
- Testing
- Regenerative periodontal surgery using Regenfast® (hyaluronic acid + polynucleotides) with Bio-Oss® graft, Regenerative periodontal surgery using Emdogain® (enamel matrix derivative) with Bio-Oss® graft
- Volunteers
- 40 people
- Sponsor
- Shashi Dadlani
Tooth Loss, Dental Implant
Tissue Preservation in Immediate 1C Implants Using an Anatomical Prefabricated Healing Abutment
The goal of this clinical trial is to evaluate whether an anatomical prefabricated healing abutment (AHA) improves tissue preservation and clinical outcomes following immediate implant placement after tooth extraction in adults.
- Conditions
- Tooth Loss, Dental Implant, Clinical Trials, Randomized Controlled Trial
- Trial name
- Aharct (NCT07727980)
- Testing
- scannable anatomical healing abutment, Standard Healing Abutment for Dental Implants
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Periodontitis
10 Year Follow up of RCT Comparing Different Regenerative Regenerative Procedures
Evaluate the 10-year stability clinical, radiographic outcomes obtained with the application of the modified minimally invasive surgery to deep pockets associated with intrabony defects.
- Trial name
- NCT05225142
- Testing
- Modified minimally invasive surgery, Modified minimally invasive surgery with enamel matrix derivative, Modified minimally invasive surgery with enamel matrix derivative and bone replacement graft
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- The European Research Group on Periodontology (ERGOPerio)
KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA
Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
This study was designed to test the efficacy and safety of low laser therapy to treat the xerostomia of patients with primary Sjogren's Syndrome.
- Conditions
- KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA, SICCA SYNDROME, PRIMARY SJOGREN SYNDROME
- Trial name
- NCT02066896
- Testing
- Lasertherapy
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of São Paulo
Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx
Erlotinib Plus Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Head and Neck Cancer
Phase I/II trial to study the effectiveness of combining erlotinib with docetaxel in treating patients who have locally advanced, recurrent, or metastatic head and neck cancer.
- Conditions
- Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx, Recurrent Squamous Cell Carcinoma of the Larynx, Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT00055770
- Testing
- erlotinib hydrochloride, docetaxel, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Cleft Palate, Hemorrhage
Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty
Randomized study evaluating the role of tranexamic acid in reducing intraoperative bleeding in palatoplasty.
- Trial name
- NCT02422056
- Testing
- Tranexamic Acid, Saline
- Volunteers
- 66 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
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