Clinical trials: Oral Cavity Disease
Behcet Syndrome
Dietary Interventions and Butyrate Production in Behçet's Patients
A dietary intervention trial will be performed on patients affected by Behçet's syndrome. Three different diets will be compared, analyzing their effects on the gut microbiota composition, on endogenous butyrate production and on…
- Trial name
- NCT03274648
- Testing
- Oral butyrate, Vegetarian diet, Habitual diet
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Toxic Epidermal Necrolysis
Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions (ACDEs): A Pilot Study
The purpose of this study is to determine whether isotretinoin is helpful in treating patients with an adverse cutaneous drug eruption known as toxic epidermal necrolysis (TEN).
- Trial name
- NCT02795143
- Testing
- Isotretinoin
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Dental Implant
The Effectiveness of Single Tufted Brush in the Management of Peri-implant Mucositis
The study aims to investigate and compare the reduction in (1) soft tissue inflammation and (2) amount of plaque accumulation at implant sites with (test) or without (control) patient administered use of single tufted brush.
- Trial name
- NCT03872687
- Testing
- single tufted brush with IDB, interdental brushes
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National University Health System, Singapore
Kidney Diseases
Dose Escalation Study to Investigate Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BAY85-3934 in Subjects With Chronic Kidney Disease (CKD)
Primary objective was to assess in subjects with CKD: Safety and tolerability of molidustat (BAY 85-3934), effects of molidustat on non-invasive hemodynamics Secondary objectives were to assess: Effects on pharmacodynamic…
- Trial name
- NCT01679587
- Testing
- Molidustat (BAY85-3934)
- Where
- 3 sites in Germany
- Volunteers
- 49 people
- Sponsor
- Bayer
Trigeminal Neuralgia, Temporomandibular Disorder
Comorbid Painful TMD Among Trigeminal Neuralgia
An observational study following up with trigeminal neuralgia patients to understand their comorbid facial pain condition, specifically temporomandibular disorder.
- Conditions
- Trigeminal Neuralgia, Temporomandibular Disorder, Myofascial Pain, Trigeminal Neuropathy
- Trial name
- TNTMD (NCT05914558)
- Testing
- Clinical appointment
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Gingivitis
Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
This will be a single-center, 12 week, examiner-blind, randomized, stratified (gender and baseline mean whole mouth MGI score), two-treatment, parallel group, clinical study in healthy adult volunteers with moderate gingivitis.
- Trial name
- NCT02750943
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gingival Recession, Localized
Extended Platelet- Rich Fibrin Membrane Combined With Vestibular Incision Subperiosteal Tunnel Access Technique to Treat Localized Gingival Recession
This study will be performed to clinically evaluate and compare the effectiveness of extended platelet-rich fibrin (e-PRF) membrane versus de-epithelized free gingival graft (DFGG) in combination with vestibular incision…
- Trial name
- alb prf REC (NCT07079293)
- Testing
- Preparation of Extended PRF, Harvesting of Free Gingival Graft and preparation of CTG, VISTA technique
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Bell Palsy
Effects of Massage Therapy and Facial PNF in Early Bell's Palsy
Effects of Massage therapy and Facial PNF in early Bell's palsy
- Trial name
- NCT05679752
- Testing
- Facial PNF technique, Massage therapy
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neuro Counsel Hospital, Pakistan
Jaw, Edentulous, Partially
Pain Severity in Flapless Dental Implant Placement Using Laser
The goal of this split-mouth randomized clinical trial study was to investigate the effect of using a laser on pain and discomfort following flapless dental implant surgery.
- Trial name
- NCT06294249
- Testing
- Laser-induced Incision, Punch Incision, Implant Placement
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Anemia of Chronic Kidney Disease
Vafseo Outcomes In-Center Experience
This trial is an investigator-initiated, multi-center, randomized (1:1), open-label, active-controlled, pragmatic study of the safety of vadadustat administered three times per week for the treatment of anemia in in-center…
- Trial name
- VOICE (NCT06520826)
- Testing
- Vadadustat, Erythropoiesis Stimulating Agent
- Where
- 5 sites in United States
- Volunteers
- 2,200 people
- Sponsor
- USRC Kidney Research
Shallow Vestibular Depth, Gingival Recession
The Relationship Between Root Coverage Procedures and Buccal Vestibular Depth
In this comparative trial, 50 patients with shallow vestibules and Type 1/2 recessions will be treated with either a vertically coronally advanced flap + connective tissue graft or a free gingival graft.
- Trial name
- NCT05777811
- Testing
- Vertically coronally advanced flap combined with connective tissue graft., Free gingival graft
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Peri-Implantitis
Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation)
The objective of the study is to evaluate the safety, effectiveness and anti-microbial effects of Arestin (minocycline HCl) 1 mg Microspheres in the treatment of subjects with peri-implantitis, when used in combination with…
- Trial name
- NCT01517334
- Testing
- Minocycline HCl Microspheres
- Where
- 10 sites in United States
- Volunteers
- 208 people
- Sponsor
- OraPharma
Periodontitis, Type 2 Diabetes Mellitus
FM-SRP and Tooth Extraction Improve Type 2 Diabetes Mellitus in Periodontitis
This intervention study is designed to evaluate the effects of non-surgical procedure in addition to surgical procedure on systemic inflammation and glycemic control in with type 2 diabetes mellitus patients with periodontitis in…
- Trial name
- NCT02874963
- Testing
- Surgical Periodontal Treatment, Non Surgical Periodontal Treatment includes scaling root planing with UDS-J Ultrasonic Scaler., Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%)
- Where
- Kosovo
- Volunteers
- 160 people
- Sponsor
- University Clinical Centre of Kosova
Abfraction
Treatment of NCCL Asociated With Gingival Recession With B.O.P.T. Technique
The purpose of this clinical trial is to evaluate the gingival margin changes resulting from the treatment with biologically oriented preparation technique (B.O.P.T.) of non-carious cervical lesions (NCCL).
- Trial name
- NCT05861193
- Testing
- Treatment of the abfraction with BOPT technique
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Head and Neck Cancer, Lung Cancer
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00021333
- Testing
- filgrastim, cisplatin, paclitaxel
- Where
- 18 sites in United States
- Volunteers
- 29 people
- Sponsor
- Fox Chase Cancer Center
Parotid Tumor
FArial NErf MRI in the Preoperative Assessment of PArotide Tumors
1. st visit: Inclusion, 3Tesla injected parotid MRI performed as part of routine care for characterization, to which two specific high resolution sequences will be added.
- Trial name
- NEFAPA (NCT04613349)
- Testing
- MRI
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Xerostomia, Head and Neck Cancers
Efficacy of Traditional Persian Medicine Preparation Versus Artificial Saliva for Radiation Induced Xerostomia
Head and neck cancers(HNC) is one of the most common cancers worldwide. Xerostomia is one of the most common side effect of radiation therapy among patients with HNC.
- Trial name
- NCT02854358
- Testing
- mixed powder of A. digitata and M. sylvestris, Hypozalix spray (artificial saliva)
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Periodontal Diseases
Clinical Relevance of Different Time of Periodontal Re-evaluation
Treatment of periodontitis follows an incremental step approach. The results after step 1 (Oral Hygiene Instruction and Professional Mechanical Plaque Removal) and 2 (subgingival instrumentation) are re-evaluated in order to…
- Trial name
- NCT06086821
- Testing
- Periodontal Re-Evaluation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Florence
Aggressive Periodontitis
Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis
Approaches and objectives related to the treatment of patients with aggressive periodontitis are not markedly different compared patients with the chronic form.
- Trial name
- NCT03025204
- Testing
- Enamel Matrix Proteins, Open Flap Debridement
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Campinas, Brazil
Spinocerebellar Ataxia 3
Clinical Effects of Oral Trehalose In Patients With Spinocerebellar Ataxia 3
There are no clinically established treatments which have been proven to delay the disease progression in spinocerebellar ataxia (SCA) 3.
- Trial name
- NCT04426149
- Testing
- trehalose
- Where
- Malaysia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
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