Clinical trials: Oral Cavity Disease
Xerostomia
Safety and Potential Effect of Innovative Cell-based Therapy Using Adipose-derived Stromal Vascular Fraction in Patients With Autoimmune Xerostomia
The main objective of this study is to evaluate the tolerance and safety of autologous adipose-derived stromal vascular fraction injected in accessory salivary glands for treatment of autoimmune xerostomia in terms of adverse…
- Trial name
- XEROCELL (NCT05857358)
- Testing
- lipoaspiration, Injection of the autologous adipose-derived stromal vascular fraction (AD-SVF)
- Volunteers
- 18 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Leukemia, Lymphocytic, Chronic, B-Cell
This Study in Patients With Chronic Lymphocytic Leukaemia is Done to Determine a Safe and Effective Dose of BI 836826 in Combination With Venetoclax
The main objective of this trial is to determine the maximum tolerated dose (MTD) of BI 836826 in combination with venetoclax on the basis of dose limiting toxicities (DLTs incidence rate during the MTD evaluation period of the…
- Trial name
- NCT03343678
- Testing
- Venetoclax, BI 836826
- Sponsor
- Boehringer Ingelheim
Periimplantitis
Adhesion of Connective Tissue Around Laser-treated Abutments for Dental Implants - Clinical Trial in Humans
This study aims to demonstrate the histological differences in the connective tissue surrounding laser-treated abutments and untreated abutments in humans.
- Trial name
- NCT01954485
- Testing
- Dental implant placement with a final prosthetic abutment
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Barcelona
Periodontitis, Obesity
Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With Obesity
The goal of this clinical trial is to compare the effects of adjuvant antimicrobial photodynamic therapy (aPDT) as an adjuvant of scaling and root planing with scaling and root planing alone for periodontal treatment in patients…
- Trial name
- NCT06073704
- Testing
- antimicrobial photodynamic therapy (aPDT), Control
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases
This study evaluates the effectiveness of topical NAVS naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS).
- Trial name
- NCT02920658
- Testing
- NAVS Naphthalan, 0.05% Betamethasone dipropionate
- Where
- Croatia
- Volunteers
- 57 people
- Sponsor
- Ivan Alajbeg
Periodontitis
The Novel Electrolyzed Water Spray Treatment Mild Periodontitis
The purpose of this study is to test whether spraying the tooth of patients by use of the novel electrolyzed water spray will produce improvement in the condition of mild periodontitis.
- Trial name
- NCT05770258
- Testing
- The novel electrolyzed water spray
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Dove Medical Press Ltd
Periodontitis
Periodontal Air-Polishing Device Versus Manual Scaling and Root Planing
This study looks at two common ways to perform deep cleaning of the gums in people with periodontitis: Airflow® (a spray system that uses fine powder and water) and hand scaling (cleaning with metal instruments).
- Trial name
- NCT07200284
- Testing
- Airpolishing device, Manual SRP
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad de Granada
Implant Infection, Alveolar Bone Loss
Associations of Alveolar Bone Loss and Interleukin-1β Levels in One and Two Stage Surgical Procedures
The present study was compared the level of alveolar bone loss, clinical parameters and IL-1β in PICF in one- or two-stage surgical procedures.
- Trial name
- NCT03045458
- Testing
- tissue level dental implant, Bone level dental implant
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Firat University
Trigeminal Neuralgia
Efficacy, Safety, and Tolerability of SR750 in Patients With Trigeminal Neuralgia
The goal of this clinical trial is to evaluate the efficacy，safety and tolerability of SR750 in patients with trigeminal neuralgia (TN).
- Trial name
- NCT06571448
- Testing
- SR750 tablet
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Shanghai SIMR Biotechnology Co., Ltd.
Periodontitis, Obesity
Investigation of Asprosin a Novel Adipokine in Periodontitis
Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc.
- Conditions
- Periodontitis, Obesity, Diabetes Mellitus
- Trial name
- NCT05449821
- Testing
- Serum and salivary samples will be collected. Asprosin levels will be determined by biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Ataturk University
Oral Mucositis
Cox-2 Inhibition in Radiation-induced Oral Mucositis
Oral mucositis refers to ulcerative lesions of the oral mucosa that occur due to radiation therapy given for treatment of head and neck cancer.
- Trial name
- NCT00698204
- Testing
- celecoxib
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- UConn Health
Canavan Disease, Infantile
Lithium and Acetate for Canavan Disease
The aim of this study is to determine whether oral supplementation with lithium and acetate may improve the biological and clinical prognosis in patients with Canavan Disease.
- Conditions
- Canavan Disease, Infantile, Deficiency Disease, Aspartoacylase
- Trial name
- NCT00657748
- Testing
- Lithium Gluconate (drug) Glyceryl Triacetate GTA (drug)
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gingivitis, Periodontitis
SmartMouth Advanced Clinical Formula Clinical Research Design Protocol
The aim of this study is to provide evidence on the clinical efficacy of SmartMouth Advanced Clinical Formula mouthrinse in comparison to the efficacy of 0.12% chlorhexidine mouthrinse and a placebo mouthrinse.
- Trial name
- NCT02709785
- Testing
- SmartMouth Clinical DDS mouthrinse, 0.12% chlorhexidine rinse
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- St. Louis University
Sjögren's Syndrome, Rheumatic Diseases
Impact of Korean Red Ginseng on Fatigue in Patients With Rheumatic Disease
The objective of a randomized, double-blind, placebo-controlled trial and open-label extension study is to figure out the impact of Korean Red Ginseng (KRG) on fatigue in patients with rheumatic diseases.
- Conditions
- Sjögren's Syndrome, Rheumatic Diseases, Korean Red Ginseng
- Trial name
- NCT03983408
- Testing
- Korean Red Ginseng
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Hanyang University
Side Effect, Ischemia Reperfusion Injury
Tongue Depressor-related Ischemia-Reperfusion Injury in Tongue
This study aimed to detect tongue edema associated with the pressure exerted by a rigid direct laryngoscope by measuring the tongue area using USG in patients undergoing suspension laryngoscopy (SL) procedures.
- Conditions
- Side Effect, Ischemia Reperfusion Injury, Edema, Tongue Enlarged
- Trial name
- NCT04205253
- Testing
- Ultrasonography imaging
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Selcuk University
Acute Bronchitis, Chronic Bronchitis
Safety/Tolerability and Efficacy of YHD001 in Patients With Acute and Chronic Bronchitis
The study will conduct with 4 comparative groups orally treated with YHD001 dose level 1(t.i.d.), YHD001 dose level 2(t.i.d.), pelargonium sidoides extract 9mL(t.i.d.) or Placebo for 7 days.
- Trial name
- NCT01420445
- Testing
- YHD001 dose level 1, YHD001 dose level 2, Pelargonium sidoides extract
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Yuhan Corporation
Alveolar Bone Loss, Alveolar Ridge Augmentation
Evaluation of Guided Tissue Regeneration With Autogenous Bone Chips and CGF During Implant Placement
CGF membranes will be prepared using a swing-lock centrifuge. A full-thickness mucoperiosteal flap will be elevated in a narrow alveolar ridge. Implants will be inserted.
- Conditions
- Alveolar Bone Loss, Alveolar Ridge Augmentation, Dental Implant
- Trial name
- CGF (NCT07521514)
- Testing
- concentrated growth factor (CGF) Membrane
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Cairo University
Apical Periodontitis, Endodontically Treated Teeth
Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery
The purpose of this study is to evaluate the effect of Photobiomodulation (PBM) in postoperative pain after endodontic microsurgery (EMS) in patients from the University of Texas Health Science Center at Houston, School of…
- Conditions
- Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst
- Trial name
- NCT06574152
- Testing
- PBM treatment, EMS
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alveolar Bone Loss
A Feasibility Study for Growth Bone Vertically With Titanium Mesh and Allograft in Lower Posterior Jaw
This study will involve placing donor bone into the back of lower jaw then covering with a newly designed titanium mesh. The mesh will then stay in the mouth for 4 months before it will be removed.
- Trial name
- NCT02255149
- Testing
- Bone/Mesh
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Periodontitis, Diabetes Mellitus
Subgingival Lactobacillus Reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Diabetic Patients
This randomized controlled clinical trial evaluates the adjunctive effect of subgingival administration of Lactobacillus reuteri probiotics in diabetic patients with Stage III Grade B or higher periodontitis receiving…
- Trial name
- LREUTERI-DM (NCT07652255)
- Testing
- Lactobacillus Reuteri Oral Solution [BioGaia], saline control
- Where
- Vietnam
- Volunteers
- 5 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
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