Clinical trials: Oral Cavity Disease
Peri-implantitis
The Efficacy and Safety of Chlorhexidine Gluconate Chip (Periochip®) in Therapy of Symptoms in Patients With Peri-implantitis
The purpose of the study is to assess the efficacy and the safety of Chlorhexidine Gluconate chip (Periochip®) versus Placebo Chip in treatment of symptoms in patients with Peri-Implantitis.
- Trial name
- NCT01079663
- Testing
- Chlorhexidine 2.5 mg
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Dexcel Pharma Technologies Ltd.
Cancer of Head and Neck
Evaluation of an Active Swallowing Rehabilitation on Quality of Life of Patients Treated by Radiotherapy for Head and Neck Cancer
Toxicity and mainly dysphagia have increased in head and neck cancers as chemoradiation indications have risen over the last decade, leading to a significant loss of quality of life for patients.
- Trial name
- RORC (NCT02892487)
- Testing
- Swallowing therapy
- Where
- 21 sites in France
- Volunteers
- 183 people
- Sponsor
- Rennes University Hospital
Double Cord Blood Transplant, Acute Myelogenous Leukemia
TXA127 in Enhancement of Engraftment in Adult Double Cord Blood Transplantation
The purpose of this study is to evaluate the effect of TXA127 on neutrophil and platelet counts in adult patients who have undergone a double cord blood transplant.
- Conditions
- Double Cord Blood Transplant, Acute Myelogenous Leukemia, Myelodysplastic Syndrome, Myelofibrosis
- Trial name
- USBTXA127CBT (NCT01300611)
- Testing
- TXA127 300 mcg/kg/day, TXA127 1000 mcg/kg/day
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tarix Pharmaceuticals
Gingival Recession
Effect of a Multi-directional Power Toothbrush on Recession
Background: Clinical studies have explored the relationship between toothbrushing and the development of recession, but relevant recession data for the multi-directional power toothbrush (PT) are lacking.
- Trial name
- NCT02530671
- Testing
- Toothbrushing with manual toothbrush, Toothbrushing with power toothbrush
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Chronic Periodontitis
Effect of the Diode Laser on Bacteremia Associated With Periodontal Flap Surgery: A Clinico-Microbiological Study
The objective of the present study is 1. To study the incidence and magnitude of bacteremia after periodontal flap surgery . 2. To compare and evaluate the effect of diode laser on frequency of bacteremia associated with…
- Trial name
- NCT04207034
- Testing
- flap surgery with diode laser, flap surgery
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Gingivitis
Efficacy of a Naturally-derived Mouthrinse for Gingival Inflammation
Gingivitis, defined as inflammation of the gingival tissues, has long been associated with bacterial accumulation [plaque] on the tooth surface adjacent to the gingiva, causing an inflammatory reaction.
- Trial name
- NCT00885599
- Testing
- Herbal API, Cepacol, Listerine Antiseptic Mouth Rinse
- Where
- Israel
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Alzheimer's Disease
A Randomized, Placebo-Controlled Trial to Examine the Efficacy of Oral Donepezil in Subjects With MCI
To purpose of this study is to estimate the effect of donepezil on Neuropsychological Testing (NPT) and brain Proton Magnetic Resonance Spectroscopy.
- Trial name
- NCT00483028
- Testing
- donezepil (Aricept)
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pfizer
Periodontitis, Adult
Clinical and Radiographic Evaluation of NIPSA Versus M-MIST in Treatment of Intra-osseous Defects
The aim: Clinical and Radiographic Evaluation for intra-osseous defects in stage III periodontitis using NIPSA versus M-MIST Steps in short Pre-surgical therapy Before surgical intervention, each patient will be given careful…
- Trial name
- NCT04149834
- Testing
- Group A (Test): Patients will receive NIPSA, Group B (Control): Patients will receive M-MIST
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hemodialysis Patients With Renal Anemia
A Long Term Study of Intermittent Oral Dosing of ASP1517 in Hemodialysis Chronic Kidney Disease Patients With Anemia Converted From Erythropoieses Stimulating Agent (ESA) Treatment
The objective of this study is to evaluate the efficacy and safety of ASP1517 in hemodialysis patients with renal anemia whose treatment is converted from an Erythropoieses Stimulating Agent formulation.
- Trial name
- NCT02779764
- Testing
- roxadustat
- Where
- 25 sites in Japan
- Volunteers
- 164 people
- Sponsor
- Astellas Pharma Inc
Alveolar Osteitis
Tackling Dry Socket Via Laser Therapy in Smokers
This study examines the efficiency of diode laser therapy to manage dry sockets after tooth extraction.
- Trial name
- NCT06481293
- Testing
- Diode laser therapy, Alveogyl dressing
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Badr University
Periodontitis
Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans
Inflammatory periodontal disease often results in loss of bone around the teeth. Bone defects that have a certain size and shape (called intrabony or intraosseous defects) may be improved by using a graft material in the bony…
- Trial name
- NCT02154906
- Testing
- DFDBA, autologous platelet rich fibrin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Periodontal Disease, Periodontitis
Investigation of the Relationship Between Periodontitis and Alzheimer's Disease in Terms of Blood Parameters
The aim of this study was to analyse the possible relationship between periodontal inflammation and Alzheimer's disease and to investigate the role of blood parameters in this relationship.
- Conditions
- Periodontal Disease, Periodontitis, Periodontal Inflammation, Biomarkers / Blood
- Trial name
- NCT07069244
- Testing
- Complete Blood Count Test, Periodontal examinations, Clinical Dementia Rating scale
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uskudar University
Burning Mouth Syndrome
Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome
What affect does the use of a mucoadhesive drug delivery system (Mucolox®) compounded with clonazepam have in the treatment of burning mouth syndrome? There are no clinical trials reported in the literature that evaluate the use…
- Trial name
- NCT02690844
- Testing
- Clonazepam mixed with Mucolox®, Mucolox® alone, Clonazepam
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Periodontitis
Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects
The purpose of this clinical trial is to compare the results in subjects with periodontitis using subjects own blood - Platelet-rich plasma (PRP) combined with bone graft material, namely, Demineralized Freeze - Dried Bone…
- Trial name
- NCT05886699
- Testing
- PRP combined with DFDBA, DFDBA
- Where
- India
- Volunteers
- 13 people
- Sponsor
- Government Dental College and Hospital, India
Trigeminal Neuralgia, Blood
Transcriptome Sequencing Analysis of Whole Blood From Patients With Trigeminal Neuralgia
Trigeminal neuralgia is a type of neuropathic pain that brings great physical and psychological pressure to patients. Chronic pain can cause changes in the composition of central and peripheral body fluids, and these changes may…
- Conditions
- Trigeminal Neuralgia, Blood, Plasma, Cerebrospinal Fluid
- Trial name
- NCT04923399
- Volunteers
- 20 people
- Sponsor
- Peking University People's Hospital
CKD, PAD
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent ± Probiotics in CKD Patients With PAD
Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD).
- Trial name
- NCT04788914
- Testing
- Active bamboo charcoal± probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Oral Cancer
Expression of VEGF-C and VEGF-CR in Oral Cancers and Premalignant Lesions
The role of vascular endothelial growth factor-C (VEGF-C) and its receptors induced lymphangiogenesis and host inflammatory responses on the carcinogenesis of oral cancers and premalignant lesions
- Trial name
- NCT00173316
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gingival Diseases
Pilot Efficacy Study to Treat Gingivitis
The primary purpose is to demonstrate the efficacy of a prescription mouthrinse in human subjects for treatment of Gingivitis.
- Trial name
- NCT00391547
- Testing
- Frio Oral Rinse
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Biomedical Development Corporation
Cleft Lip and Palate
Fabrication of Naso-alveolar Molding (NAM) Appliance in Cleft Lip and Palate (CLP) From Digital Magnetic Resonance Imaging (MRI) Face Scan
The purpose of this study is to fabricate a nasoalveolar molding (NAM) appliance that is digitally fabricated and 3 dimensionally printed utilizing an MRI face scan and to assess the fit of the NAM in new borns with cleft lip and…
- Trial name
- NCT04369638
- Testing
- 3D NAM, Traditional NAM
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The University of Texas Health Science Center, Houston
Edentulous Mouth, Complete Edentulism
Attachment Types for Single-implant Mandibular Overdentures: a Crossover Clinical Trial
Dental implants are often the preferred treatment option and in some clinical scenarios they are considered the standard of care to restore missing or damaged teeth, due to the limitations of conventional treatments.
- Trial name
- SIMODA (NCT03048812)
- Testing
- O'Ring Attachment (A), Equator Attachment (B)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
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