Clinical trials: Oral Cavity Disease
Vaginal Flora Imbalance, ASC-US
"Lactobacillus Crispatus M247, LSIL and Microbiota"
Patients affected by ASC-US/ low-grade HPV cervical lesions will be randomly assigned to treatment arm vs control arm. The treatment arm will include the characterization of the vaginal microbiota at enrollment (T0), 4 months of…
- Conditions
- Vaginal Flora Imbalance, ASC-US, LSIL, HPV Infection
- Trial name
- NCT05808816
- Testing
- Lactobacillus Crispatus M247
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gingival Overgrowth
Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth
This study will examine common features of gingival overgrowth (excessive growth of the gums around the teeth) that develops in patients with the hereditary form of the condition and in those who develop the condition as a side…
- Trial name
- NCT00104026
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Halitosis, Periodontitis
Oral Malodour and Periodontal Disease-related Parameters
The primary aim of the current study was to determine the association between halitosis detection (presence or absence) and periodontal status in non-smoking subjects, and also assess whether halitosis recordings were related to…
- Conditions
- Halitosis, Periodontitis, Gingivitis
- Trial name
- NCT01234948
- Where
- Greece
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Gingivitis
Personalized 3D Visualization for Oral Hygiene and Motivation in Adults With Gingivitis
This study evaluated whether personalized three-dimensional images of possible future changes in the gums could improve oral hygiene and motivation in adults with gingivitis.
- Trial name
- NCT07826715
- Testing
- Conventional Oral Hygiene Education, Three-Dimensional Animation-Based Oral Hygiene Education, Personalized Three-Dimensional Visualization With Motivational Discussion
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Denture Stomatitis
The Effect of Palatal Brushing on Denture Stomatitis
Palatal brushing has several advantages including removal of debris and stimulation of blood flow and saliva, which may help to prevent or treat oral diseases, such as denture-related stomatitis in complete denture wearers.
- Trial name
- NCT01643876
- Testing
- Palatal brushing
- Where
- 2 sites in Brazil, Canada
- Volunteers
- 48 people
- Sponsor
- Université de Montréal
Cirrhosis, Periodontal Diseases
Oral Health In Cirrhosis of the Liver (ORACLE)
The goal of this observational study is to learn about dental evaluation and periodontal cleaning along with scheduled follow -up on the dental health and overall health of patients with cirrhosis and also to determine what…
- Trial name
- ORACLE (NCT06052150)
- Testing
- Dental exam and periodontal cleaning if needed
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Alveolar Bone Loss
Clinical Trial on the Safety and Efficacy of Magnesium Doped Calcium Silicate 3d Alveolar Bone Repair Unit for Periodontal Bone Defects
The goal of this clinical trial is to test in height increment of alveolar bone and safety evaluation index. The main question it aims to answer are: The safety and effectiveness of magnesium calcium silicate three-dimensional…
- Trial name
- NCT05743452
- Testing
- GBR with CS@Mg
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Huntington Disease
An Exploratory Clinical Trial in Early Stage Huntington's Disease Patients With SEN0014196
The primary objective of this study is to provide biological samples from patients with Huntington's disease to allow characterisation of the pharmacological mechanism of action of SEN0014196.
- Trial name
- PADDINGTON (NCT01485952)
- Testing
- SEN0014196 (Low Dose), SEN0014196 (High Dose)
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Siena Biotech S.p.A.
Parkinson Disease
Safety, Tolerability and Effects of Mannitol in Parkinson's Disease
Parkinson's disease is a progressive neurodegenerative disease that causes disabling motor and cognitive impairments. Currently, no disease-modifying therapy exists for this disease.
- Trial name
- PD-mannitol (NCT03823638)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Periodontal Diseases, Smoking Cessation
Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy
The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease.
- Trial name
- NCT06145685
- Testing
- Minimally invasive non-surgical periodontal therapy, Conventional non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Alveolar Osteitis
Photo Biomodulation Therapy for Alveolar Osteitis Recovery in Oral Contraceptive Users
does laser effect on alveolar osteitis recovery in oral contraceptive users ?
- Trial name
- NCT06865508
- Testing
- Laser therapy, zinc oxide eugenol dressing.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Badr University
Measles, Mumps
A Study of ProQuad™ in Healthy Children in Korea (V221-023)
This study will compare ProQuad™ and concomitant administration of M-M-R™ II and Varivax™ with respect to immunogenicity, safety and tolerability.
- Conditions
- Measles, Mumps, Rubella, Varicella
- Trial name
- NCT00839917
- Testing
- Measles, Mumps, Rubella and Varicella (Oka-Merck) Virus Vaccine Live (ProQuad™), M-M-R™ II and Varivax™
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Peri-Implantitis
Non-surgical Treatment of Peri-implantitis With and Without Erythritol Air-polishing
Erythritol is a natural sugar alcohol (a four-carbon polyol) produced by the reduction of erythrose. It is considered safe as food additive and has many of the functional properties that are important for subgingival debridement.
- Trial name
- NCT04152668
- Testing
- Titanium curette., Ultrasonic, Air-polishing
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Knut N. Leknes
Peri-implantitis
Non-Surgical Treatment of Peri-implantitis with Systemic Azithromycin or Placebo
The primary objective of this study is to evaluate the change in probing depth in patients with peri-implantitis, assessing the influence of systemic antibiotic (azithromycin) adjunctive to non-surgical treatment at 12 months.
- Trial name
- NSTP (NCT06715150)
- Testing
- Azithromcyin
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- University of Santiago de Compostela
Edentulous Jaw
An Observational Clinical Study of the T3 Dental Implant System
This will be a prospective, observational study where all implants will be placed in either the maxilla or mandible and loaded immediately (within 48 hours), early (within 6-8 weeks) or delayed (> 8 weeks) with a provisional or…
- Trial name
- Kashmir (NCT05062863)
- Testing
- T3 dental implant system
- Where
- 4 sites in United States, Germany
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- ZimVie
Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis
Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome
This clinical research focus on evaluating the effectiveness of Huanglian-Jiedu Decoction in patients with intense-exuberant stomach fire syndrome (one of the common TCM syndrome)of acute pericoronitis,minor recurrent aphthous…
- Conditions
- Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis, Recurrent Aphthous Stomatitis, Recurrent Herpes Simplex Labialis
- Trial name
- NCT03469232
- Testing
- Huanglian-Jiedu Decoction
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- China Academy of Chinese Medical Sciences
Periodontal Diseases
Evaluation of PerioMonitor for Detection of Oral Inflammatory Load (OIL) in Human Subjects
The purpose of this multicenter, prospective, single arm Study is to evaluate the efficacy and safety of PerioMonitor as an aid to the presumptive detection of oral inflammation associated with periodontal diseases.
- Trial name
- NCT05153798
- Where
- 3 sites in United States, Canada
- Volunteers
- 117 people
- Sponsor
- Oral Science International Inc.
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases
To evaluate the safety of UTAA09 injection in the treatment of relapsed/refractory (R/R) autoimmune disease (AID). To evaluate the pharmacokinetic (PK) profile of UTAA09 injection in patients with R/R AID.
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, Sjogren's Syndrome
- Trial name
- NCT06417398
- Testing
- T cell injection targeting CD19 chimeric antigen receptor
- Volunteers
- 10 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
PRF, Gingival Recession
Clinical Evaluation of Platelet Rich Fibrin Membrane With or Without Hyaluronic Acid Along With Coronally Advanced Flap in the Treatment of Rt1 Gingival Recession
Gingival recession is a common mucogingival deformity that may result in root hypersensitivity, esthetic concern, plaque accumulation, and difficulty in oral hygiene maintenance.
- Conditions
- PRF, Gingival Recession, Hyaluronic Acid
- Trial name
- NCT07662447
- Testing
- root coverage with multilayered PRF, root coverage with multilayered PRF and hyaluronic acid
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Alzheimer Disease
BnH-015B Clinical Trial in Moderate Alzheimer's Disease
BnH-015B is a small molecule compound that targets the GluN2B binding site on NMDA receptors and positively modulates. BnH-015B has shown, through nonclinical trials, to improve symptoms of cognitive decline by regulating the…
- Trial name
- NCT06535308
- Testing
- BnH-015B 5 mg, BnH-015B 10 mg, BnH-015B 20 mg
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- BnH Research
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