Clinical trials: Oral Chemotherapy
Solid Tumor
The Intersection of Oncology Care and Worker Well-Being
The goals of this study will be a greater understanding of cancer patients' well-being experience through the care/treatment continuum.
- Trial name
- NCT05250284
- Testing
- WellBQ, PROMIS
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Colorado, Denver
Arthritis, Rheumatoid
Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and efficacy of TAK-715, twice daily (BID), in the treatment of rheumatoid arthritis signs and symptoms in patients with a partial response to methotrexate.
- Trial name
- NCT00760864
- Testing
- TAK-715 and methotrexate, Methotrexate
- Volunteers
- 432 people
- Sponsor
- Takeda
Oral Mucositis, Head and Neck Neoplasms
Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region
The present study aims to evaluate the effectiveness of a combined protocol of professional and at-home ozone therapy in the treatment of oral mucositis in patients undergoing radio- and/or chemotherapy.
- Trial name
- NCT07247799
- Testing
- Ozone treatment
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Andrea Scribante
Carcinoma, Non-Small-Cell Lung
LUME-Columbus: Nintedanib Plus Docetaxel in Advanced Non-small Cell Lung Cancer With Translational Research
The present trial will investigate the efficacy and safety of nintedanib in combination with docetaxel as compared to placebo in combination with docetaxel in patients with stage IIIB/IV or recurrent NSCLC of adenocarcinoma…
- Trial name
- NCT02231164
- Testing
- docetaxel, nintedanib
- Where
- 13 sites in United States, Georgia and 1 more
- Volunteers
- 12 people
- Sponsor
- Boehringer Ingelheim
Hematological Neoplasms, Non-Hodgkin's Lymphoma
Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies
This is a Phase 1, open-label, multicenter, randomized, 2-stage crossover study consisting of 2 phases: Stage I - Pharmacokinetics (Bioequivalence), with an Extension Stage II - Pharmacokinetics (Food Effect) with an Extension…
- Conditions
- Hematological Neoplasms, Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma, Lymphoma
- Trial name
- NCT02223052
- Testing
- CC-486, Vidaza
- Where
- 10 sites in United States
- Volunteers
- 89 people
- Sponsor
- Celgene
HIV Infections
Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adults
HIV replication in resting CD4 cells is so minimal that anti-HIV drugs often fail to destroy the virus in these cells. Enfuvirtide, also known as T-20, is a type of anti-HIV drug called a fusion inhibitor.
- Trial name
- NCT00051831
- Testing
- Emtricitabine, Enfuvirtide, Ritonavir
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 19 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mucositis, Hematopoietic Stem Cell Transplantation
Oral Selenium Therapy for the Prevention of Mucositis
Selenium as an antioxidant and anti-inflammatory agent could be effective in prevention of mucositis induced by chemotherapy and radiotherapy.
- Trial name
- NCT01432873
- Testing
- Oral selenium
- Where
- Iran
- Volunteers
- 76 people
- Sponsor
- Tehran University of Medical Sciences
Head and Neck Cancer
Cisplatin, Fluorouracil, Iressa, and Radiation Therapy Patients With Locally Advanced Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00352105
- Testing
- cisplatin, fluorouracil, Iressa
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David Adelstein
Head and Neck Cancer, Mucositis
Oral Glutamine and Mucositis of Head and Neck Cancer Patients Undergoing Radiation
This study will enroll 60 consecutive patients who are scheduled to receive radiotherapy with/without chemotherapy due to head and neck cancers. Basic data will be recorded along with tumor related variables.
- Trial name
- NCT02282839
- Testing
- Glutamine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Chemotherapy Induced Mucositis
Curcumin for Prevention of Oral Mucositis in Children Chemotherapy
Mucositis consists of inflammation of the mucosal membrane and is a prominent cause of patient discomfort during cancer therapy.
- Trial name
- NCT00475683
- Testing
- Mouth wash, Curcumol
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Hadassah Medical Organization
Multiple Myeloma and Plasma Cell Neoplasm
Chemotherapy Plus Steroid Therapy in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00003603
- Testing
- cyclophosphamide, dexamethasone, idarubicin
- Where
- United Kingdom
- Volunteers
- 660 people
- Sponsor
- Riverside Haematology Group
Head and Neck Cancer, Oral Mucositis
Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer
This study will evaluate the ability of grape exosomes, given to the subject as grape powder, as an important anti-inflammatory agent to reduce the incidence of oral mucositis during radiation and chemotherapy treatment for head…
- Trial name
- NCT01668849
- Testing
- Grape extract, Lortab, Fentanyl patch, mouthwash
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Louisville
Advanced Solid Tumors, Relapsed/Refractory Lymphoma
Pharmacokinetics of Alisertib in Adults With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Function
The purpose of this study is to evaluate the effect of moderate or severe hepatic impairment on the single-dose pharmacokinetics of alisertib in adult participants with cancer.
- Trial name
- NCT02214147
- Testing
- Alisertib
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents
A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935
The purpose of this study is to determine the brain cholesterol 24S-hydroxylase (CH24H) enzyme occupancy of TAK-935 after single oral dose in healthy participants using the positron emission tomography (PET) ligand [18F]MNI-792…
- Trial name
- NCT02497235
- Testing
- TAK-935, [18F]MNI-792 (tracer)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Takeda
Sarcoma, Soft Tissue
Ph II Nintedanib vs. Ifosfamide in Soft Tissue Sarcoma
This is a prospective, multicentric, randomized, open label Phase II trial investigating whether the oral angiogenesis inhibitor nintedanib, as compared to the intravenous cytotoxic compound ifosfamide, given for patients with…
- Trial name
- ANITA (NCT02808247)
- Testing
- Nintedanib, Ifosfamide
- Where
- 13 sites in Belgium, France and 5 more
- Volunteers
- 80 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Unspecified Adult Solid Tumor, Protocol Specific
Chemotherapy in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of carbendazim in treating patients who have advanced solid…
- Trial name
- NCT00003709
- Testing
- carbendazim
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pneumonia, Pneumocystis Carinii, HIV Infections
Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
To compare the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium) with that of conventional therapy (sulfamethoxazole-trimethoprim) in the treatment of moderately severe…
- Trial name
- NCT00001014
- Testing
- Trimetrexate glucuronate, Sulfamethoxazole-Trimethoprim, Leucovorin calcium
- Where
- 6 sites in United States
- Volunteers
- 302 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy
Multicentre Real-life Data Collection Study With CareMin650™ in the Prevention and Treatment of Oral Mucositis and Radio- and/or Chemo-induced Dermatitis
Most patients with cancer or haematological malignancies who receive chemotherapy - broadly defined to include targeted therapies and immunotherapy - and/or external beam radiotherapy may experience serious and disabling adverse…
- Conditions
- Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Oral Mucositis (Ulcerative) Due to Radiation, Dermatitis
- Trial name
- NéoPBM (NCT07054528)
- Where
- France
- Volunteers
- 33,000 people
- Sponsor
- Centre Hospitalier de Valenciennes
Acute Lymphoblastic Leukemia (ALL)
Bright Ideas - CIN Feasibility Study
In this study investigators will determine the feasibility of a future trial comparing chemotherapy-induced nausea control in children with ALL receiving oral 6-mercaptopurine who do and do not receive problem-solving skill…
- Trial name
- NCT04929899
- Testing
- Bright Ideas - CIN Training
- Where
- 4 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- The Hospital for Sick Children
Dental Anxiety
Flumazenil Reversal of Oral Triazolam
An increase in the utilization of anesthesia and sedation medications by non-anesthesiologists, including dentists, has grown dramatically.
- Trial name
- NCT00695630
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington