Clinical trials: Oral Complication
Pain, Postoperative
Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery.
- Trial name
- NCT02487303
- Testing
- Acetaminophen Intravenous, Acetaminophen Oral
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Depression, Depressive State
A Study to Compare the Pharmacokinetic Profiles of Etravil® Tablet 10mg and Etravil® Tablet 25mg
To evaluate the pharmacokinetics of single oral dose of Amitriptyline hydrochloride film-coated tablet 10mg \& 25mg
- Conditions
- Depression, Depressive State, Enuresis
- Trial name
- DWETR (NCT01367080)
- Testing
- DWETR10, DWETR25
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dong Wha Pharmaceutical Co. Ltd.
Bone Loss, Implant Complication
The Effects of Dis/Reconnection of Implant Abutments on Peri-implant Bone Levels
The aim of this study was to evaluate the effects of definitive abutment connection at the time of implant placement on peri-implant bone levels and soft tissue changes in posterior maxilla and mandible regions.
- Conditions
- Bone Loss, Implant Complication, Gingival Recession
- Trial name
- NCT04043286
- Testing
- Definitive abutment
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Nephropathy
A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
The purpose of this study is to compare the efficacy of oral N-acetylcysteine and intravenous sodium bicarbonate for the prevention of Contrast-Induced Nephropathy (CIN) after cardiac catheterization.
- Trial name
- PROTECt (NCT00579995)
- Testing
- Oral N-Acetylcysteine, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Contraception
Side Effect Profiles of Brand Name Versus Generic Oral Contraceptives
This is a randomized control trial of Ortho tricyclen versus Trinessa (generic equivalent) to determine if they have similar effects.
- Trial name
- NCT00775190
- Testing
- ortho tricyclen, Trinessa
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Mastitis
Global Effects of a Probiotic Strain on Lactating Women
In this study, the investigators will try to confirm if application of probiotic strains isolated from breast milk actually have a beneficial effect on women suffering lactational mastitis.
- Trial name
- PROBIOLAC (NCT01124448)
- Testing
- Lactobacillus salivarius PS2
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Postoperative Pain
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy
Purpose: To compare the efficacy of oral gabapentin and its newer analogue pregabalin in postoperative pain control after photorefractive keratectomy (PRK).
- Trial name
- NCT00954187
- Testing
- Gabapentin, pregabalin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Urinary Tract Infections
Safety, Tolerability and Pharmacokinetic Investigation of GSK3882347 in Healthy Participants.
This is a phase 1, 2-part, double-blind (sponsor-unblinded), randomized, placebo-controlled, first time in human (FTIH) study, that includes both single-ascending and multiple-ascending dose phase to assess the safety…
- Trial name
- NCT04488770
- Testing
- GSK3882347
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Severe Renal Impairment
Safety, Tolerability, and Pharmacokinetic of Single Dose of Pitavastatin 4 mg in Severe Renal Patients Versus Healthy Adult Volunteers
This is a Phase 4, multicenter, open label, 1 period study. A total of 16 subjects are planned (8 subjects in Group A and 8 subjects in Group B): The 2 groups will be comparable in terms of age, gender, and body mass index (BMI)…
- Trial name
- NCT01043094
- Testing
- Pitavastatin 4mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Polycystic Ovary Syndrome
Insulin Resistance, Polycystic Ovary Syndrome, and Bone Research Study
The purpose is to investigate the effects of 2 different treatments (drospirenone/ethinyl estradiol versus rosiglitazone) on insulin sensitivity and androgen levels, inflammatory markers, vascular markers and bone development in…
- Trial name
- NCT00640224
- Testing
- rosiglitazone, drospirenone/ethinyl estradiol
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Silva Arslanian
Cystitis, Interstitial, Dysmenorrhea
Chronic Pain Risk Associated With Menstrual Period Pain
The purpose of this study is to determine if some women with dysmenorrhea (painful periods) are at higher future risk of developing chronic pelvic pain (CPP) and if oral contraceptives (OC) can be used to reverse this chronic…
- Conditions
- Cystitis, Interstitial, Dysmenorrhea, Migraine Disorders, Pelvic Pain
- Trial name
- CRAMPP (NCT02214550)
- Testing
- cyclic microgestin 1/20, continuous microgestin 1/20
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Polycystic Ovary Syndrome
Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy
Oral contraceptives are known to improve menstrual cycles and symptoms in PCOS, however may increase cholesterol. Metformin, a drug to improve insulin resistance, may benefit metabolic state.
- Trial name
- NCT00283816
- Testing
- Metformin, Oral Contraceptive Pill, Lifestyle Management Program
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Preterm Birth, Tube Feeding
Maternal Role in Oral Feed Establishment in Preterm Neonates
Hypothesis Preterm babies who receive sensory motor stimulation from their mothers as compared to trained nurses will 1. Start taking oral feed at the same time as compared to control group 2.
- Conditions
- Preterm Birth, Tube Feeding, Swallowing Disorder, Maternal Care Patterns
- Trial name
- NCT05484726
- Testing
- perioral sensory motor stimulation
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Fatima Memorial Hospital
Vulvovaginal Candidiasis, Candida Infection
Pharmacokinetic Study in Healthy Lactating Women Exposed to Ibrexafungerp
This is a pharmacokinetic evaluation of lactating women after receiving two doses of Ibrexafungerp. The study population included healthy lactating females who were at least 10 days postpartum with a fully established milk supply…
- Conditions
- Vulvovaginal Candidiasis, Candida Infection, Vaginal Candidiasis
- Trial name
- NCT06954493
- Testing
- Ibrexafungerp
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Scynexis, Inc.
Vesicoureteral Reflux
Midazolam Effect in Children Undergoing Voiding Cystourethrogram (VCUG)
The purpose of this research is to validate the common administration of oral midazolam to children prior to voiding cystourethrogram (VCUG) to see if this will significantly decrease children's anxiety and make the experience…
- Trial name
- NCT00894465
- Testing
- midazolam
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dysfunctional Uterine Bleeding
DMPA & High Dose Oral Progestin (MPA) Tablets in Outpatient Treatment of Acute Excessive Vaginal Bleeding
The purpose of this study is to investigate the effectiveness and acceptability of high dose MPA (20mg oral 3 times a day) for 3 days combined with an injection of DMPA 150 mg intramuscularly in the treatment of acute heavy…
- Trial name
- NCT01148420
- Testing
- Medroxyprogesterone 17-Acetate, medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Women's Health Care Clinic, Torrance, California
Heart Failure
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 986 Administered Orally to Healthy Volunteers and Participants With Severely Impaired Renal Function
A study to assess the safety, tolerability, and pharmacokinetics of AMG 986 given orally as a single dose to healthy participants and participants with severely impaired kidney function.
- Trial name
- NCT03318809
- Testing
- AMG 986
- Where
- 4 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Amgen
Renal Insufficiency, Healthy
A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Kidney Problems
This study is open to adults aged 18 years and older. People without kidney problems and people who have moderate or severe kidney problems can join the study.
- Trial name
- NCT05718648
- Testing
- BI 1015550
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Maternal Death, Maternal Infections Affecting Fetus or Newborn
Azithromycin-Prevention in Labor Use Study (A-PLUS)
Maternal and neonatal infections are among the most frequent causes of maternal and neonatal deaths, and current antibiotic strategies have not been effective in preventing many of these deaths.
- Conditions
- Maternal Death, Maternal Infections Affecting Fetus or Newborn, Neonatal SEPSIS, Maternal Sepsis During Labor
- Trial name
- NCT03871491
- Testing
- Azithromycin
- Where
- 8 sites in Bangladesh, Democratic Republic of the Congo and 5 more
- Volunteers
- 58,747 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health