Clinical trials: Oral Immunotherapy for Food Allergy
Oral Immunotherapy for Food Allergy
Predictors of Positive Food Challenge
Patients with suspected tree-nut or sesame allergy based on sensitization on skin-prick tests (SPT), will be assessed for allergy using component analysis and basophil activation test (BAT) and entered into oral immunotherapy…
- Trial name
- NCT02786914
- Where
- Israel
- Volunteers
- 250 people
- Sponsor
- Assaf-Harofeh Medical Center
Peanut Allergy
Peanut Oral Immunotherapy Study of Early Intervention for Desensitization
The purpose of this study is to determine the efficacy and safety of AR101 in peanut-allergic children aged 1 to < 4 years.
- Trial name
- POSEIDON (NCT03736447)
- Testing
- AR101 powder provided in capsules & sachets
- Where
- 23 sites in United States, France and 2 more
- Volunteers
- 146 people
- Sponsor
- Aimmune Therapeutics, Inc.
Peanut Hypersensitivity
Peanut Oral Immunotherapy and Anti-Immunoglobulin E (IgE) for Peanut Allergy
The purpose of this study is to determine whether the addition of anti-IgE treatment will make peanut oral immunotherapy safer, more tolerable, and more effective in treating peanut allergy.
- Trial name
- PAIE/Xolair (NCT00932282)
- Testing
- Peanut Oral Immunotherapy, Omalizumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of North Carolina, Chapel Hill
Cow's Milk Allergy
Use of Baked Milk in Oral Immunotherapy for Severe IgE-mediated Cow's Milk Protein Allergic Patients
Oral immunotherapy (OIT) programs for milk, egg and peanut, desensitize patients to their respective allergens and thereby decrease their risk of morbidity and mortality.
- Trial name
- NCT01968278
- Testing
- Baked milk
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Peanut Hypersensitivity
Oral Immunotherapy (OIT) for Peanut Allergy
Peanut allergy is known to cause severe anaphylactic reactions.The goal of this proposal is to produce a new treatment that would benefit subjects who have peanut allergy by lowering the risk of anaphylactic reactions…
- Trial name
- PnOIT3 (NCT00815035)
- Testing
- Peanut OIT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Cow's Milk Allergy
Baked Milk Oral Immunotherapy for Cow's Milk Allergy
The purpose of this study is to determine whether baked milk oral immunotherapy is safe in the treatment of cow's milk allergy.
- Trial name
- NCT03462030
- Testing
- Baked non-fat cow's milk powder
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Johns Hopkins University
Peanut Allergy
Oral Low Doses Tolerance INduction Study for Peanuts
Several protocols have been proposed in scientifis literature, for oral tolerance induction (OIT) protocols for peanuts. A meta-analysis showed that the data in the literature are rather in favor of the exclusion of peanuts, and…
- Trial name
- OLDTINYpeanut (NCT04881773)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Montpellier
Hen Egg Allergy
Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy
To determine the efficacy and safety of AR201 in a characterized oral desensitization immunotherapy (CODIT™) regimen in hen egg-allergic subjects aged 4 to 26 years, inclusive.
- Trial name
- NCT04056299
- Testing
- AR201 powder
- Where
- 11 sites in United States
- Volunteers
- 15 people
- Sponsor
- Aimmune Therapeutics, Inc.
Peanut Hypersensitivity, Food Hypersensitivity
A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut Allergy
The purpose of this study is to explore the safety and efficacy of a sublingual (under the tongue) immunotherapy (SLIT) dosing regimen and an oral immunotherapy (OIT) regimen in inducing desensitization and long term tolerance in…
- Conditions
- Peanut Hypersensitivity, Food Hypersensitivity, Immediate Hypersensitivity
- Trial name
- NCT01084174
- Testing
- Peanut powder, Peanut extract
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Johns Hopkins University
Peanut Allergy
Oral Immunotherapy for Young Children With Peanut Allergy - Small Children OIT
Open label study with peanut oral immunotherapy (OIT). Peanut allergic children aged 1-3 years of age will be randomized 2:1 to: 1.
- Trial name
- SmaChO (NCT04511494)
- Testing
- Peanut (bamba)
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Karolinska Institutet
Peanut Allergy
Walnut Oral Immunotherapy for Tree Nut Allergy
The purpose of this research study is to learn about the medical effects, safety, and how the Walnut Oral Immunotherapy (OIT) treatment affects your body (immune system).
- Trial name
- NCT01918657
- Testing
- walnut powder
- Where
- United States
- Sponsor
- Jonathan Spergel
Peanut Allergy
VE416 for Treatment of Food Allergy
This is a single-center, randomized, double-blind trial with four arms evaluating VE416 as pretreatment or concurrent treatment in comparison to low-dose peanut oral immunotherapy (PNOIT) alone.
- Trial name
- NCT03936998
- Testing
- Vancomycin plus VE416 before PNOIT, Vancomycin plus VE416 with PNOIT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Food Hypersensitivity
Oral Immunotherapy for Peanut Allergy (PMIT)
The purpose of this study is to determine if mucosal peanut immunotherapy will make subjects who have peanut allergy less allergic and induce changes in their immune system.
- Trial name
- PMIT (NCT00597675)
- Testing
- Peanut OIT
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Allergy;Food, Wheat Allergy
Randomized Controlled Trial for Wheat Oral Immunotherapy
IgE-mediated wheat allergy is a growing allergy problem in children, and affected children can predict with immediate-type allergic reactions to the extent of anaphylactic shock.
- Conditions
- Allergy;Food, Wheat Allergy, Children
- Trial name
- WOIT-RCT (NCT06069492)
- Testing
- Wheat-containing food
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- Chinese University of Hong Kong
Peanut Allergy
Food Oral Immunotherapy for Peanut Allergy
This is an open label observational single center study of clinical food oral immunotherapy outcomes with biomarker samples and participant and/or caregiver-completed questionnaires in participants between 6 months and 65 years…
- Trial name
- NCT04222491
- Testing
- Peanut oral immunotherapy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Milk Allergy
Swedish Study of Immunotherapy for Milk Allergy in Children
This trial is a two-armed open randomized controlled trial in children aged 5-15 years with challenge proven Immunoglobulin E (IgE)-associated milk allergy.The purpose is to determine if oral immunotherapy with milk can induce…
- Trial name
- SWITCH (NCT03819556)
- Testing
- Milk protein in fresh milk
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Can Milk Allergic Patients Tolerate Baked Milk Products
Oral Immunotherapy With Baked Milk Products for Patients Allergic to Cow's Milk - A Multicenter Study
Based on the current knowledge, the investigators hypothesized that most children with milk allergy in Israel would be able to ingest baked milk products daily, thus benefiting from improved nutrition and dietary variety and…
- Trial name
- NCT01760837
- Testing
- Baked milk products to cow's milk allergic patients
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Wolfson Medical Center
Food Allergy
Improving the Safety of Oral Immunotherapy for Cow's Milk Allergy
Allergy to cow's milk is the most common food allergy affecting children. There is currently no accepted routine clinical therapy to cure milk allergy.
- Trial name
- SOCMA (NCT02216175)
- Testing
- SLIT to cow's milk, Low dose OIT, Conventional OIT to cow's milk
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 68 people
- Sponsor
- Imperial College London
Hypersensitivity, Immediate Hypersensitivity
Oral Immunotherapy for Childhood Egg Allergy
The purpose of this study is to determine if oral immunotherapy (OIT) will desensitize a child with an allergy to egg and eventually lead to the development of tolerance to egg.
- Conditions
- Hypersensitivity, Immediate Hypersensitivity, Food Hypersensitivity
- Trial name
- NCT00461097
- Testing
- Egg oral immunotherapy, Control Group
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tree Nut Allergy
Walnut Oral Immunotherapy for Tree Nut Allergy
The purpose of this study is to determine if walnut oral immunotherapy can be used in participants allergic to tree nuts to reduce tree nut allergy and induce changes in the participant's immune system.
- Trial name
- WOIT (NCT01546753)
- Testing
- Walnut Protein Powder, Open-label Walnut Protein Powder
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Arkansas