Clinical trials: Oral Lichen Planus
Oral Lichen Planus
Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus
Glucosamine (GlcN) is an N-deacetyl amino sugar derived from the complete hydrolysis of chitosan with recently reported immunoregulatory capacity and anti-inflammatory effect and was administrated orally in osteoarthritis and…
- Trial name
- NCT02858297
- Testing
- Glucosamine sulfate, triamcinolone acetonide
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Lichen Planus, Oral
Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1 to 4%. The clinics forms are many and symptoms are varied.
- Trial name
- LICHENVIR (NCT02276573)
- Testing
- buccal cavity sample
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lichen Planus, Oral, Lichen Planus, Mucosal
Efficacy and Safety of Baricitinib in Oral Lichen Planus: a Proof-of-Concept Study
The goal of this clinical trial is to learn the effects of baricitinib (the study drug) in patients with Oral Lichen Planus. The main questions it aims to answer are: What is the efficacy of baricitinib in treating moderate to…
- Conditions
- Lichen Planus, Oral, Lichen Planus, Mucosal, Oral Lichen Planus
- Trial name
- NCT06158113
- Testing
- Baricitinib 4 milligram Oral Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Oral Lichen Planus
Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease characterized by outbreaks or flares. It affects 0.2-1.9% of the population.
- Trial name
- lichenPlanus (NCT02421770)
- Testing
- Chamaemelum nobile 2%
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Murcia
Oral Lichen Planus
Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus
Introduction :Oral lichen planus (OLP) is one of the most common disorders of the oral cavity which is basically a chronic and inflammated mucocutaneous .There is no cure for OLP currently.
- Trial name
- NCT02453503
- Testing
- Licorice, Triamcinolone Acetonide
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Oral Lichen Planus, Oral Lichenoid Reaction
Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus
The objective of this study is to see the amount of systemic absorption of a standard dose of dexamethasone oral rinse for patients with symptomatic oral lichen planus (OLP) or oral lichenoid reactions (OLR) and healthy subjects…
- Trial name
- NCT06428630
- Testing
- dexamethasone oral rinse
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Oral Lichen Planus
Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension
Lesions of the lichen planus type within the oral mucosa are now considered a potentially cancerous condition. One of the minimally invasive methods of treating these lesions is photodynamic therapy, and the gold standard in…
- Trial name
- NCT04991012
- Testing
- PDT Therapy, Triamcinolone (Substance) therapy side
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Oral Lichen Planus
Oral Lichen Planus Treatment
Oral lichen planus (OLP) is a chronic inflammatory and immune-mediated disease affecting the oral mucosa. OLP presents with asymptomatic, lacelike white stripes and/or symptomatic red, ulcerated mucous membranes.
- Trial name
- NCT05127083
- Testing
- Patients will be treated with localized PBM with a diode laser
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Murcia
Oral Leukoplakia, Oral Leukoplakia of Tongue
Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore
Oral squamous cell carcinomas (OSCC) is among the most common malignancies worldwide. Early detection and prevention of OSCC is thought to have the highest potential to reduce morbidity and mortality.
- Conditions
- Oral Leukoplakia, Oral Leukoplakia of Tongue, Oral Leukoplakia of Gingiva, Oral Lichen Planus
- Trial name
- PREDICT-OLP (NCT03975322)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Lichen Planus, Oral, Low-Level Light Therapy
Photobiomodulation in Oral Lichen Planus
The aim of this study was to compare the efficacy of PBM (660nm) and corticosteroid therapy with clobetasol propionate 0.05% in the treatment of OLP. This is a protocol for a randomized, controlled, double blind clinical trial.
- Trial name
- NCT03320460
- Testing
- Propionate clobetasol gel 0.05%, Photobiomodulation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Nove de Julho
Lichen Planus, Oral
Efficacy of Purslane in Treatment of Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory disease whose prevalence in the general population is 0.5 -2.2%.Oral lesions in OLP are chronic, rarely undergo spontaneous remission.
- Trial name
- NCT00746772
- Testing
- Purslane 235mg/day in one dosage
- Where
- Iran
- Volunteers
- 37 people
- Sponsor
- Qazvin University Of Medical Sciences
Oral Lichen Planus, Topical Sulfasalazine
Topical Sulfasalazine and Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucosal membrane. T-cell mediated damage against the mucosal epithelial cells is implicated in the pathogenesis of OLP, although the exact mechanism is…
- Conditions
- Oral Lichen Planus, Topical Sulfasalazine, Corticosteroids
- Trial name
- NCT06060301
- Testing
- sulfasalazine 500 MG, corticosteroids
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University
Oral Lichen Planus
A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus
Oral lichen planus (OLP) is a common sub-acute, chronic inflammatory mucocutaneous disease.This study was evaluated the comparative efficacy of lycopene and prednisolone for the treatment of oral lichen planus.
- Trial name
- OLP (NCT02587117)
- Testing
- lycopene, Prednisolone
- Volunteers
- 28 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Lichen Planus, Oral
Efficacy of Elidel Cream on Erosive Oral Lichen Planus
The purpose of this study is to investigate whether topical applied pimecrolimus will lead to improvement of erosive oral lichen planus.
- Trial name
- NCT00130572
- Testing
- Pimecrolimus
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Oral Lichen Planus, Oral Lichen Planus Related Stress
Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus
The goal of this clinical trial is to learn if a mucoadhesive patch containing clobetasol alone or in combination with resveratrol can reduce symptoms and improve quality of life in adults with Oral Lichen Planus (OLP).
- Conditions
- Oral Lichen Planus, Oral Lichen Planus Related Stress, Oral Mucosal Disease, Oral Pain
- Trial name
- EMPATIA (NCT07100613)
- Testing
- Clobetasol Patch, Clobetasol + Resveratrol Patch, Clobetasol in Orabase
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Palermo
Erosive Oral Lichen Planus
Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus
After signing the informed consent, the participant will be allocated to either intervention or control group, then each participant in the intervention group will receive intralesional injections of platelet rich plasma…
- Trial name
- NCT03293368
- Testing
- Platelet rich plasma, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Oral Lichen Planus
Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus
Bromelain, an enzyme extract derived from pineapples, has shown promise due to its anti-inflammatory and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored.
- Trial name
- NCT06981767
- Testing
- Topical Bromelain, 0.1% topical triamcinolone acetonide, Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions
This study aims to identify the accuracy of DNA integrity index in differentiating between oral premalignant lesions and oral cancer.
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia
- Trial name
- NCT03682562
- Testing
- DNA Integrity Index
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Oral Lichen Planus, Biopsy
Discomfort Following Oral Biopsy Comparing Laser and Punch Biopsy
Oral biopsy is essential for diagnosing mucosal lesions such as oral lichen planus (OLP). Laser surgery offers a minimally invasive alternative to traditional techniques, but thermal effects may impact healing and postoperative…
- Trial name
- OLP_BIOP (NCT07414797)
- Testing
- Laser Biopsy, Punch Biopsy
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- Catholic University of the Sacred Heart