Clinical trials: Oral Lichen Planus
Oral Lichen Planus
The Efficacy of Topical Sesame Oil Versus Topical Triamcinolone on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker [MDA]
use seseme oil and corticosteroid topically for two groups
- Trial name
- (MDA) (NCT03738176)
- Testing
- Sesame Oil, triamcinolone in orabase
- Volunteers
- 40 people
- Sponsor
- Mona Taha Mohammed MD
Lichen Planus, Oral, Preneoplastic Condition
Treatment Protocols for Patients With Symptomatic Oral Lichen Planus
The primary objective of this study was to compare the therapeutic efficacy of clobetasol propionate 0.05% oral gel versus an anti-inflammatory mouthwash in an oral solution for the management of patients suffering from…
- Trial name
- NCT04673916
- Testing
- Healing evaluation
- Where
- Italy
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Messina
Oral Leukoplakia, Oral Lichen Planus
Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Abstract Objective: To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions.
- Conditions
- Oral Leukoplakia, Oral Lichen Planus, Premalignant Lesion
- Trial name
- NCT03031899
- Testing
- Biopsy, Rose Bengal, toluidine blue
- Volunteers
- 27 people
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Oral Lichen Planus
Matrix Metalloproteinases Neutralizing Agents in Oral Lichen Planus
The current study will be conducted to evaluate the effectiveness of matrix metalloproteinases inhibitors on erosive oral lichen planus.
- Trial name
- NCT04336488
- Testing
- Matrix Metalloproteinase Inhibitors (Orochem), Kenacort A,
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Jaylane kadry Ghonima
Oral Lichen Planus, Vitamin D Deficiency
Vitamin D Deficiency As a Risk Factor for the Development and Malignant Transformation of Oral Lichen Planus
To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.
- Trial name
- NCT06033105
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Lichen Planus
Metagenomic Analysis of the Oral Microbiome in Patients With Oral Lichen Planus: A Pilot Study in the Turkish Population
Lichen planus is a common chronic mucocutaneous inflammatory disease that affects the skin, nails, eyes, urogenital system, and oral mucosa. Oral lichen planus (OLP) specifically occurs in the oral cavity.
- Trial name
- NCT07137156
- Testing
- cytobrush, next-generation sequencing
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Oral Lichen Planus, Tumor Necrosis Factor-alpha
Efficacy of Aloe Vera Compared to Corticosteroid in Topical Treatment of Oral Lichen Planus and on Salivary Levels of Tumor Necrosis Factor Alpha
Aloe Vera Herbal treatment has been widely used as an anti-inflammatory and antioxidant the objective of this study was to evaluate the clinical efficacy of Aloevera gel compared to corticosteroid gel o for symptomatic oral…
- Trial name
- NCT07792512
- Testing
- aloevera gel, Topical Corticosteroid Creams (Triamcinolone acetonide 0.1% and Hydrocortisone 2.5%)
- Where
- 5 sites in Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus
The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP).
- Trial name
- NCT06932848
- Testing
- Curcumin in Nanogels, 0.1% Fluocinolone Acetonide Oral Paste
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Oral Lichen Planus, Thyroid Diseases
Association of Oral Lichen Planus and Thyroid Disease
Thyroid disease is a common endocrine disorder. Oral lichen planus (OLP) is a chronic autoimmune disease that occurs on the oral mucosa in 1-2% of the general population.The purpose of this study was to determine whether there is…
- Trial name
- NCT04523077
- Testing
- determination of thyroid hormones and antibodies
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Lichen Planus, Oral
Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus
This study is to determine whether efalizumab 1.0mg/kg given by subcutaneous injection for 12 weeks is effective in treating oral lichen planus. This is a 20 week, single center, open-label pilot study to enroll 5 subjects.
- Trial name
- NCT00133107
- Testing
- efalizumab
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Oral Lichen Planus
Prevalence of Lichen Planus
Clinical records of all patients referred to the Department of Oral diseases and periodontology in the period 2021-2023 were retrogradely assesed.
- Trial name
- NCT06787872
- Where
- Slovenia
- Volunteers
- 111 people
- Sponsor
- University of Ljubljana
Oral Lichen Planus
Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid
Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients.
- Trial name
- NCT03871114
- Testing
- Triamcinolone Acetonide in orabase
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus, Diabetes Mellitus
The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2)
Diabetes mellitus is among the most common chronic diseases, with significant and well documented impact on oral cavity health. Among the most common diseases of the oral cavity mucosa and complications in patients with impaired…
- Trial name
- NCT03257228
- Testing
- comparative semiquantitative immunohistochemistry
- Volunteers
- 24 people
- Sponsor
- University of Zagreb
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography
This clinical trial aims to assess the efficacy of Optical Coherence Tomography (OCT) in the early diagnosis of oral cancer. It focuses on Oral Potentially Malignant Disorders (OPMDs) as precursors to Oral Squamous Cell Carcinoma…
- Conditions
- Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder, Oral Leukoplakia, Proliferative Verrucous Leukoplakia
- Trial name
- SYMILIS OCT (NCT06321003)
- Testing
- OCT (Optical Coherence Tomography)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Lichen Planus
Dexamethasone Solution for the Treatment of Oral Lichen Planus
The objective of this single center, 4-week, open label randomized, phase II study is to evaluate and characterize the tolerability and clinical effectiveness of dexamethasone 0.5mg/5ml solution in a mucoadhesive vehicle…
- Trial name
- NCT02850601
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Oral Lichen Planus
Prolactin Hormone in Oral Lichen Planus
Oral lichen planus (OLP) is one of the most common mucosal diseases with autoimmune etio-pathogenesis with involvement of various cytokines similar to psoriasis.It generally occurs more commonly in females, in a ratio of 3:2.
- Trial name
- NCT04785703
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- October University for Modern Sciences and Arts
Sore Throat, Aphthous Ulcer
Observational Study of OROSEDAL in Sore Throat and Minor Oral Lesions
This prospective, multicenter, national, observational, non-interventional post-market clinical follow-up study will evaluate the performance and safety of OROSEDAL in children and adults with sore throat or minor oral lesions…
- Conditions
- Sore Throat, Aphthous Ulcer, Oral Lichen Planus, Minor Mouth Lesion
- Trial name
- NCT07620353
- Testing
- OROSEDAL
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Laboratoires Elerte
Erosive Lichen Planus
Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus
The aim of this study was to evaluate the effect of oral lycopene and systemic steroids in the treatment of erosive oral lichen planus and compare between the two therapeutic modalities.
- Trial name
- NCT04652739
- Testing
- Lycopene Softgel, 10 Mg, Prednisolone
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Nourhan M.Aly
Oral Lichen Planus, Oral Cancer
the Oncogenic Potential of Salivary miRNA-93 and miRNA-412-3P in Oral Lichen Planus Patients
Assessment The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus
- Trial name
- NCT05400057
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Moataz Mahmoud
Oral Erosive Lichen Planus
Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream
Background and hypothesis. Oral erosive lichen planus (OELP) is a severe form of mucosal lichen planus. Lesions often induce intense pain and limit feeding. Its course is chronic with flares and spontaneous remissions are rare.
- Trial name
- NCT00321750
- Testing
- 1% pimecrolimus cream
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nice