Clinical trials: Oral Microbiota
Bacterial Infections
Effect of Xylitol on Oral Microbiota in Children
1. The present controlled, randomized, doubleblind study aims to answer the following questions: How will the "normal flora" be affected by the xylitol consumption? Will daily consumption of xylitol change the plaque-saliva…
- Trial name
- NCT01528969
- Testing
- xylitol, sorbitol
- Where
- Kuwait
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Kuwait University
C. Difficile
Fecal Microbiota Transplantation to Treat Recurrent C. Difficile Associated Diarrhea Via Retention Enema or Oral Route
The objective of the study is to investigate the safety of a frozen or lyophilized inoculum administered, respectively, by retention enema or capsules in patients with recurrent C. difficile associated diarrhea (RCDAD).
- Trial name
- NCT02449174
- Testing
- Frozen Microbiota, Lyophilized Microbiota
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The University of Texas Health Science Center, Houston
Periodontitis, Rheumatoid Arthritis
Effect of Nonsurgical Periodontal Therapy (NSPT) on Rheumatoid Arthritis Subjects With Periodontitis
Periodontitis (PD), a chronic inflammatory disease which results in irreversible attachment loss, bone destruction and, if left untreated, tooth loss.
- Trial name
- NCT05880303
- Testing
- Nonsurgical periodontal therapy
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- University of Malaya
Oral Squamous Cell Carcinoma, Medication Related Osteonecrosis of the Jaw
The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck, and its incidence has increased in recent years.
- Conditions
- Oral Squamous Cell Carcinoma, Medication Related Osteonecrosis of the Jaw, Oral Epithelial Dysplasia
- Trial name
- NCT03418454
- Testing
- Buccal mucosa samples for Extraction of BACTERIAL DNA
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Saliva Altered, Taste, Altered
Taste Perception, Salivary Proteins & the Oral Microbiome
Genetic differences in taste are believed to play an important role in food selection, especially for strong-tasting foods and beverages.
- Trial name
- NCT04107688
- Testing
- Control, CPE
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers University
CKD
Study of Oral Uremic Toxin Absorbent and Probiotics to Retard the Progression of Chronic Kidney Disease
In patients with chronic kidney disease (CKD), uremic toxins accumulate when kidney function declines. Those uremic toxins had a greater affinity to circulating proteins are called "protein bound uremic toxins, PBUT." Apart from…
- Trial name
- NCT04819217
- Testing
- Active bamboo charcoal, Probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Dental Caries, Gingivitis
Effect of a 2-week Sugar Stress on Bacterial Profiles in Whole Saliva
Dental caries is a non-communicable biofilm-mediated disease affecting both crown and exposed root surfaces in the primary and permanent dentitions.
- Trial name
- NCT04199897
- Testing
- Succrose rinsing, Probiotic lozenges, xylitol rinsing
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Pregnancy, Periodontal Disease
Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy
This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women…
- Conditions
- Pregnancy, Periodontal Disease, Gingivitis, Dental Plaque
- Trial name
- PREG-Q10 (NCT07029360)
- Testing
- Limosilactobacillus reuteri Prodentis®, Coenzyme Q10 Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Infertility, Female, Polycystic Ovary Syndrome
Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF
The aim of the study is to study the effect of an antioxidant food supplement associated with probiotics on the oocyte quality response, oxidative stress and microbiota function in an in vitro fertilization cycle in patients with…
- Trial name
- NCT04670393
- Testing
- FertyBiotic Woman Plus
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fertypharm
Oral Microbiome
The Probiotic for Oral Health (PRO Health) Study
The PRO Health Study is a single-center, prospective, double-blind, randomized, placebo-controlled trial of streptococcus-containing supplementation in healthy adults.
- Trial name
- PRO Health (NCT03748017)
- Testing
- Streptococcus-Containing Probiotic Supplement
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Mouth Diseases
Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene
The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days.
- Trial name
- NCT02913235
- Testing
- Oral hygiene discontinuation group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Oral Health
Dysbiosis of Methanogenic Archaea and Nanoarchaea in the Oral Microbiome
Need to improve understanding of oral dysbiosis in the elderly and/or immunocompromised individuals (involvement of nanogenes in these dysbiosis) Comparison of dysbiosis identification between results from dental plaque samples…
- Trial name
- METHAORAL (NCT07521644)
- Testing
- Dental plaque sample, Saliva sample
- Where
- France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Oral Microbiota, Pancreatitis
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
There are more than 700 different bacteria colonized in human oral cavity, which are collectively referred to as oral microbiota.
- Conditions
- Oral Microbiota, Pancreatitis, Pancreatic Cancer
- Trial name
- NCT07015580
- Testing
- 16S rRNA sequencing
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Head and Neck Cancer, Oral Mucositis
Commensal Oral Microbiota in Head and Neck Cancer
The ARMOR Trial will test the efficacy of an oral care protocol to treat oral mucositis (OM) in patients receiving radiation (RT) or chemoradiation (chemoRT) for head and neck cancer.
- Trial name
- ARMOR (NCT03843554)
- Testing
- Standard of Care Oral Hygiene, Oral mucosal deterging and dental prophylaxis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Cardiovascular Diseases, Diabetes
Białystok PLUS - Polish Longitudinal University Study
The main goal of the study is to provide a unique multidimensional picture of the health of the population with simultaneous optimal standards of sampling, processing and storing of data and biomaterial that will allow…
- Conditions
- Cardiovascular Diseases, Diabetes, Neuro-Degenerative Disease, Obesity
- Trial name
- Bialystok+ (NCT03197363)
- Testing
- Discovering novel risk factors.
- Where
- Poland
- Volunteers
- 8,320 people
- Sponsor
- Medical University of Bialystok
Impacted Third Molar Tooth
Changes in Resistome After Dental Extraction and Amoxicillin.
The aim of this study is to evaluate the nature of the change in oral and gut bacterial resistance profiles after antibiotic therapy for a surgical procedure in two groups.
- Trial name
- NCT02830347
- Testing
- Amoxicillin, Extraction
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Periodontitis
PAROMIP Pilot Study PAROdontites & MIcrobiota Periodontal
A new classification of periodontal diseases was created in 2018. the investigators want to know if this clinical classification is based, or not, on a biological reality.
- Trial name
- PAROMIP (NCT04251650)
- Testing
- subgingival plaque sample, CGF sample
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Dental Caries
Impact of Atraumatic Restorative Treatment and Oral Health Promotion on Psychological and Salivary Aspects of Children
This study evaluated the impact of atraumatic restorative treatment associated with oral health educational strategy on dental anxiety, oral health-related quality of life and salivary biochemical and microbiological…
- Trial name
- NCT03100773
- Testing
- Oral health educational strategy, Atraumatic Restorative Treatment
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Healthy Volunteers
Effect of Tebipenem on Normal Human Intestinal Microbiota
The overall purpose of this study is to support the development of an oral formulation of TBPM-PI-HBr by assessing the potential ecological effects of tebipenem on the normal intestinal microbiota as compared to the effects of…
- Trial name
- NCT04376554
- Testing
- TBPM-PI-HBr, amoxicillin-clavulanate
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Reproductive Health
Anti-Inflammatory Diet and Physical Activity for Reproductive Health in Adolescent Girls
This study will evaluate whether a 16-week anti-inflammatory dietary intervention, delivered alone or together with a physical activity programme, can improve diet quality and support reproductive health in girls aged 14-19…
- Trial name
- 4fertil (NCT07834489)
- Testing
- Anti-Inflammatory Dietary Intervention, Physical Activity and Training Programme
- Where
- 2 sites in Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education