Clinical trials: Oral Microbiota
Rheumatoid Arthritis, Psoriatic Arthritis
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
- Trial name
- NCT01198509
- Testing
- doxycycline, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Autism Spectrum Disorder, Autism
Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Autism Spectrum Disorder and Associated GI Symptoms (SPROUT)
Adolescent autism spectrum disorder subjects with associated GI symptoms will be randomized to receive oral dosing of CP101 capsules in Treatment Group I or matching placebo capsules in Treatment Group II.
- Conditions
- Autism Spectrum Disorder, Autism, ASD, Autistic Thinking
- Trial name
- SPROUT (NCT03829878)
- Testing
- CP101
- Sponsor
- Finch Research and Development LLC.
Morbid Obesity
Changes of Oral and Intestinal Microbiota After Bariatric Surgery
Purpose The aim of this study was to analyze the changes of microbiota among patients undergoing LSG or LRYGB on two levels of gastrointestinal tract (using oral swab and stool sample).
- Trial name
- NCT04582006
- Testing
- Bariatric surgery
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Jagiellonian University
Peri-Implantitis
Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis
This randomized clinical trial evaluates the clinical and microbiological (microbial complexes and changes in the diversity of the submucosal biofilm) effects of MTZ+AMX as adjuncts to anti-infectious surgical treatment plus Er…
- Trial name
- NCT05444218
- Testing
- Open flap debridement, Er: YAG irradiation, Metronidazole
- Where
- Brazil
- Volunteers
- 89 people
- Sponsor
- University of Guarulhos
Malnutrition, End Stage Renal Disease
Oral Nutritional Supplement on Nutritional and Functional Status, and Biomarkers in Malnourished Hemodialysis Patients.
Malnutrition in hemodialysis patients is frequent and it is associated with a reduction in muscular mass, strength, functional capacity and quality of life, with an increment in inflammatory and oxidative markers, and with a…
- Trial name
- RENACARE (NCT03924089)
- Testing
- Oral nutritional supplement with probiotics, Oral nutritional supplement without probiotics, Dietary recommendations
- Where
- 3 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Microbial Composition
Optimization of Collection Methods for Studies of the Human Microbiota
Background: The human microbiota is the bacteria and other microbes found in and on the human body. Scientists study the microbiota because it is related to many health conditions.
- Trial name
- NCT03731702
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Low-grade Oral Dysplasia
Lactobacillus Lozenges as Preventative Care in Low-grade Dysplasia
There are limited evidence-based management options for patients with low-grade oral dysplasia. Despite the risk of malignant transformation, management is frequently limited to risk factor reduction (such as smoking cessation)…
- Trial name
- NCT05707702
- Testing
- Probiotic oral lozenges, Standard of care for oral dysplasia
- Where
- United States
- Sponsor
- Boston Medical Center
Tooth Decay, Probiotics
Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp
To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for…
- Conditions
- Tooth Decay, Probiotics, Streptococcus Mutans
- Trial name
- NCT05859646
- Testing
- Probiotic use
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Didem Sakaryali Uyar
Sarcopenia
Sarcopenia, Active Aging and Oral Microbiota. Effects of HIIT in Older Adults
To analyze the effects of a high intensity exercises program by intervals on sarcopenia, active aging and oral microbiota in older adults.
- Trial name
- NCT05220670
- Testing
- HIIT, MICT
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Jaén
Pregnancy
The Effect of Under-nutrition on the Human Microbiota
The purpose of this study is to determine whether a difference exists in the gut, oral, vaginal and human milk microbiome of under-nourished pregnant women as compared to healthy and obese pregnant women.
- Trial name
- NCT02021799
- Testing
- Moringa and Lactobacillus rhamnosus GR-1
- Where
- Tanzania
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
COVID-19, Microbial Colonization
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
- Conditions
- COVID-19, Microbial Colonization, Oral Disease, Periodontal Diseases
- Trial name
- MIMSA (NCT05212766)
- Testing
- COVID infection, COVID vaccination, Oral examination
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- King's College London
Autistic Spectrum Disorder, Constipation
Oral Administration of Polyethylene Glycol (PEG) for 6 Months in Chronically Constipated Autistic Children
Many autistic children suffer from chronic constipation. Gut mobilization was obtained administering polyethylene glycol (PEG) at the dose of 6.9 g/d once a day for 6 months in an open trial involving 21 chronically constipated…
- Trial name
- NCT05025553
- Testing
- Gut mobilization
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- University of Messina
Alzheimer's Disease
An Investigation Into the Feasibility of Beetroot Juice Supplementation in People Living With Alzheimer's Disease.
The goal of this clinical trial is to learn if taking a beetroot juice supplement will work in people living with Alzheimer's disease.
- Trial name
- OMNI (NCT07258004)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of the West of Scotland
Periodontitis, Chronic Kidney Diseases
Association Between Periodontitis and Chronic Kidney Disease
The goal of this observational study is to explore the comorbid association between periodontitis and chronic kidney disease (CKD) based on the oral-renal axis in adults aged 18 to 75 years.
- Trial name
- NCT07506590
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yu Tang
Upper Respiratory Tract Infections
Probiotic Trial for URTI Prevention in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial in generally healthy adults aged 18-65 years will compare the incidence of upper respiratory tract infections (URTIs) over 16 weeks between probiotic supplement and…
- Trial name
- NCT07908797
- Testing
- Probiotic Formula
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Dry Eye Syndrome, Xerophthalmia
To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome
This study wants to use a randomized, single-blind, controlled trial to evaluate the efficacy of receiving acupuncture GB20 or GB20 plus BL2 on alleviating the ocular dryness symptom from dry eye syndrome and Sjögren's syndrome.
- Trial name
- NCT04877483
- Testing
- Acupuncture, Oral microbiota, Schirmer's test
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gingivitis, Periodontal Inflammation
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Conditions
- Gingivitis, Periodontal Inflammation, Orthodontic Appliance Complication
- Trial name
- NCT04606186
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Adults With Ulcerative Colitis
Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative Colitis
The purpose of the study is to evaluate the efficacy and safety of lyophilized PRIM-DJ2727 capsules given orally in subjects with ulcerative colitis at remission stage.
- Trial name
- NCT04373473
- Testing
- PRIM-DJ2727
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- The University of Texas Health Science Center, Houston
Periodontitis, Surgery
Metronidazole vs Azithromycin in Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
The objective of this study is to determine whether, in patients with non treated periodontitis (stage III and IV) positive to Porphyromonas gingivalis, the use of systemic antimicrobials (metronidazole versus azithromycin) as an…
- Trial name
- NCT03862456
- Testing
- Azithromycin, Metronidazole
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid