Clinical trials: Oral Microbiota
Microbial Colonization, COVID-19 Respiratory Infection
Impact of Teeth Brushing in Ventilated COVID-19 Patients.
The aims of this study were: 1. Observation of dynamics in oral microbiota and its association with the incidence of HAIs and VAP in mechanically ventilated COVID-19 patients in an ICU setting 2.
- Conditions
- Microbial Colonization, COVID-19 Respiratory Infection, Dysbiosis, VAP - Ventilator Associated Pneumonia
- Trial name
- NCT05575050
- Testing
- Oral Procedure
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- University Hospital in Krakow
Oral Health
Administration of Oral Probiotic Streptococcus Salivarius K12
The clinical trial is investigating the oral administration of probiotic Streptococcus salivarius K12 in the form of lozenges in healthy adults.
- Trial name
- NCT07757360
- Testing
- Probiotic
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Periodontitis, Alzheimer Disease
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority.
- Trial name
- ORAMICAL (NCT05077618)
- Testing
- sampling of dental plaque and blood sample during the treatment
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy, Vaginal Discharge
Vaginal and Oral Microbiome Crosstalk
To study the vaginal and oral microbiome by swab samples. On selected cases, also papa smear will be studied.
- Trial name
- NCT02898818
- Testing
- vaginal and oral swab sample, questionnaire, papa smear
- Where
- Finland
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Oral Bacterial Colonization, Oral Hygiene
Effects of Three Oral Hygiene Protocols on Oral Bacteria in Intensive Care Patients
Patients in intensive care may develop changes in the bacteria found in their mouths. Some of these bacteria can cause infections, and patients who cannot clean their own teeth depend on staff to provide oral care.
- Trial name
- NCT07868549
- Testing
- Mechanical Oral Hygiene, Chlorhexidine, Hexetidine
- Where
- Croatia
- Volunteers
- 86 people
- Sponsor
- University of Zagreb
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
RBX7455 Before Surgery for the Treatment of Operable Breast Cancer
This clinical trial studies the side effects and possible benefits of RBX7455 given before surgery in treating patients with breast cancer that can be removed by surgery (operable).
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04139993
- Testing
- Microbiota-based Formulation RBX7455
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Subthreshold Depression
Dietary Education Intervention for Subthreshold Depression (MIND-Trial)
This randomized controlled trial evaluates the efficacy of an 8-week dietary education intervention in adults with subthreshold depression.
- Trial name
- NCT07880652
- Testing
- Mediterranean-Style Dietary Education Program, Befriending
- Where
- Singapore
- Volunteers
- 64 people
- Sponsor
- Institute of Mental Health, Singapore
Cardiovascular Health, Identify Oral Bacteria Responsible for Nitrate Reduction
The Effect of Dietary Nitrate on the Oral Microbiome
This study evaluates whether dietary manipulation of the oral microbiota modulates cardiovascular health through effects on nitric oxide bioavailability.
- Trial name
- Microbio (NCT03467061)
- Testing
- Nitrate-rich beetroot juice, Nitrate-depleted beetroot juice, Mouthwash
- Where
- United Kingdom
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Chronic Periodontitis, Type 2 Diabetes Mellitus
Chronic Periodontitis Microbiota in Type 2 Diabetes Mellitus Patients
This study is a retrospective comparative evaluation of six main periodontal pathogens and total bacterial load in chronic periodontitis patients affected or not by type 2 diabetes mellitus by polymerase chain reaction analysis.
- Trial name
- NCT03786133
- Testing
- Analysis of microbiological tests
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Vaginal Microbiota, Microbiota
Effect of Hifas Intima Oral on Vaginal Microbiota in Healthy Women
The goal of this clinical trial was to learn whether the vaginal microbiota changed after healthy women aged 18 to 45 years took Hifas Intima, an oral food supplement, for 3 months.
- Conditions
- Vaginal Microbiota, Microbiota, Vaginal Microbiome
- Trial name
- NCT07715058
- Testing
- Hifas INTIMA Oral
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hifas da Terra S.L.
Autism Spectrum Disorder, Autism
Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Autism Spectrum Disorder and Associated GI Symptoms (SPROUT)
Adolescent autism spectrum disorder subjects with associated GI symptoms will be randomized to receive oral dosing of CP101 capsules in Treatment Group I or matching placebo capsules in Treatment Group II.
- Conditions
- Autism Spectrum Disorder, Autism, ASD, Autistic Thinking
- Trial name
- SPROUT (NCT03829878)
- Testing
- CP101
- Sponsor
- Finch Research and Development LLC.
Digestive Cancer
Association Between Composition of the Gut Microbiota and Nutritional Status in Digestive Oncology
Nutritional status represents a crucial issue in the management of cancer patients, as between 40% and 60% of them suffer from malnutrition at the time of diagnosis.
- Trial name
- ONCONUTRIBIOTA (NCT07260617)
- Testing
- Not applicable- observational study
- Where
- 3 sites in France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC)
Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis
The goal of this clinical trial is to learn how oral vancomycin therapy may contribute in treating paediatric inflammatory bowel disease, particularly atypical ulcerative colitis and PSC-associated colitis.
- Conditions
- Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC), Pediatric Inflammatory Bowel Diseases
- Trial name
- VERDA (NCT07646223)
- Testing
- Oral Vancomycin
- Where
- Finland
- Volunteers
- 140 people
- Sponsor
- Tampere University Hospital
Microbiome, Pancreatic Neoplasms
Fecal and Oral Microbiota Between Pancreatic Cancer and Benign/Low-grade Malignant Tumor Patients
Significant gaps exist in understanding the gastrointestinal microbiota in patients with pancreatic cancer (PCA) versus benign or low-grade malignant pancreatic tumors (NPCA).
- Conditions
- Microbiome, Pancreatic Neoplasms, 16s RRNA
- Trial name
- NCT06659237
- Testing
- 16s rRNA or shotgun metagenomics
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Peking Union Medical College Hospital
Oral Microbiome Health
Efficacy of VRx MyBiotics Oral Lozenges
This study will test the efficacy of Viome's VRx MyBiotics Oral Lozenges at improving the oral microbiome.
- Trial name
- NCT05972330
- Testing
- VRx MyBiotics Oral Lozenges
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Viome
Carbapenem-Resistant Enterobacteriaceae Infection, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for Decolonization of Carbapenem-resistant Enterobacteriaceae
The emergence of multidrug-resistant organisms (MDROs) has become one of the major threats to the healthcare system in Hong Kong in recent years.
- Trial name
- FMT (NCT05981430)
- Testing
- Fecal microbiota transplant
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
Tuberculosis
Potential Role of Microbiome in Tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a deadly infectious disease and major global public health problem.
- Trial name
- Micro-STOP (NCT04985994)
- Where
- 2 sites in Pakistan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Periodontitis
Amoxicillin and Metronidazole During or After the Periodontal Treatment
This randomized clinical trial aimed to compare the clinical and microbiological effects of different times of administration of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of periodontitis.
- Trial name
- NCT06177119
- Testing
- Scaling and root planing, Metronidazole during SRP, Amoxicillin during SRP
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Belén Retamal-Valdes
Anorexia Nervosa
Fecal Microbiota Transplantation in Females With Anorexia Nervosa
The goal of this clinical trial is to learn whether fecal microbiota transplantation (FMT) can change the gut microbiome and improve health outcomes in females with anorexia nervosa.
- Trial name
- AN-SHIFT (NCT07877675)
- Testing
- Fecal Microbiota Transplantation Capsule
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Andreas Munk Petersen
Behçet Disease, Physiopathology
Understanding the Role of Oral Microbiota in Behçet's Disease (BEHCETBIOT)
Behçet's disease (BD) is a systemic vasculitis that affects, especially, young people. Although its etiology remains unexplained, data suggest that the inflammatory response during BD results from a disruption of the homeostasis…
- Conditions
- Behçet Disease, Physiopathology, Microbiota, Oral Microbiota
- Trial name
- BEHCETBIOT (NCT04959435)
- Testing
- biological samples collection
- Where
- 2 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Clermont-Ferrand