Clinical trials: Oral Mucositis in Patients Undergoing HSCT
Oral Mucositis
Photobiomodulation for the Prevention of Oral Mucositis
The goal of this clinical trial is to learn if photobiomodulation works to prevent severe oral mucositis in patients who are undergoing allogeneic hematopoietic cell transplantation.
- Trial name
- NCT07290413
- Testing
- Photobiomodulation - INTRAORAL, Photobiomodulation - EXTRAORAL, Photobiomodulation - INTRAORAL and EXTRAORAL
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Brigham and Women's Hospital
Mucositis, Multiple Myeloma
Melphalan and Palifermin in Treating Patients Undergoing An Autologous Peripheral Stem Cell Transplant for Stage II or III Multiple Myeloma
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00482846
- Testing
- Palifermin, melphalan, questionnaire administration
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Oral Mucositis, Bone Marrow Transplant Complications
Assessment of Efficacy of LightWalker (Nd:Yag, Er:Yag) Laser Therapy on Incidence, Severity and Duration of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT). Prospective Randomized Open-label Study
Oral mucositis (OM) is a common and debilitating adverse effect of conditioning regimens in patients undergoing hematopoietic cell transplantation (HCT). It is treated symptomatically with pain relief medications.
- Trial name
- NCT05175222
- Testing
- Laser therapy
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Oral Mucositis, Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy
Study of a Copaiba-Based Mouthwash Combined With Low-Level Laser Therapy in the Prevention of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation
Oral mucositis (OM) one of the most significant acute toxicity of Hematopoietic Stem Cell Transplantation (HSCT). There is already scientific evidence suporting OM the use of: low-level laser therapy (LLLT), cryotherapy (in…
- Conditions
- Oral Mucositis, Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Oral Mucositis Due to Chemotherapy, Oral Mucositis in Patients Undergoing HSCT
- Trial name
- NCT07810530
- Testing
- Copaíba
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Mucositis, Multiple Myeloma
Comparative Trial of Cryotherapy Versus Caphosol Versus Saline Solution Mouth Washes for the Prevention of Oral Mucositis in Patients With Multiple Myeloma Undergoing Hematopoietic Stem Cell Transplantation
Chemotherapy-induced oral mucositis is the inflammation of the oral mucous membranes, which are tissues that line the mouth. Oral mucositis is caused when chemotherapy attacks and kills the rapidly-dividing cells in the oral…
- Trial name
- NCT01066624
- Testing
- 0.9% Sodium Chloride irrigation solution, Cryotherapy (ice chips), Calcium phosphate (Caphosol) Ca2+/PO43- mouth rinse
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Oral Mucositis in Patients Undergoing HSCT
A Phase III Study of Efficacy of Lactobacillus CD2 Lozenges in Preventing High-Dose Chemotherapy Induced Oral Mucositis in Patients Undergoing Myeloablative Hematopoietic Stem Cell Transplantation
The study will be conducted at departments of Medical Oncology and Hematology, All India Institute of Medical Sciences (AIIMS). Patients with various malignancies who are taken up for high dose chemotherapy followed by stem cells…
- Trial name
- mucositis (NCT01797952)
- Testing
- Lactobacillus CD 2
- Where
- India
- Sponsor
- All India Institute of Medical Sciences
Gastrointestinal Mucositis, Malignant Neoplasm
Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell Transplant
This randomized phase II trial is studying palifermin to see how well it works compared with a placebo in preventing oral mucositis caused by chemotherapy and/or radiation therapy in young patients undergoing stem cell…
- Trial name
- NCT00728585
- Testing
- Palifermin
- Sponsor
- Children's Oncology Group
Oral Mucositis, Hematopoietic Stem Cell Transplantation (HSCT)
Effect of a Standardized Oral Care Program on Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial(SOC-HSCT)
Oral mucositis is one of the most common and debilitating complications in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- SOC-HSCT (NCT07809451)
- Testing
- Standardized Oral Care Intervention, Routine Oral Care
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Leukemia, Aplastic Anemia
Methadone as an Alternative Treatment for Children Underdoing HSCT
Mucositis is a normal side effect of stem cell transplant which happens as a result of chemotherapy being given prior to a new donor cell infusion (bone marrow transplant).
- Conditions
- Leukemia, Aplastic Anemia, Bone Marrow Failure Syndromes, SCID
- Trial name
- MATCH (NCT06940570)
- Testing
- PCA plus methadone (Experimental), PCA Alone (SOC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Stomatitis
Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy
Radiotherapy and high dose chemotherapy with bone marrow transplantation or peripheral blood stem cell transplantation is frequently used as treatment for patients with cancers of the bone marrow or lymph nodes such as Hodgkin's…
- Trial name
- NCT00041665
- Testing
- Recombinant Human Keratinocyte Growth Factor
- Sponsor
- Amgen
Hematopoietic Stem Cell Transplantation, Low-Level Light Therapy
Low Power Laser Therapy As Prevention Of Oral Mucositis And Oropharyngeal Pain In Patients Undergoing Allogenetic HSCT
Objective: To compare the effects of two low-power laser therapy protocols (application of a wavelength in the mouth, red region and another in the neck infrared region X simultaneous dual application of two wavelengths, red and…
- Conditions
- Hematopoietic Stem Cell Transplantation, Low-Level Light Therapy, Stomatitis
- Trial name
- NCT06071637
- Testing
- Double low-power laser therapy simultaneous applicated
- Where
- 2 sites in Brazil
- Volunteers
- 84 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Peripheral Blood Stem Cell Transplantation
Incidence and Factors Associated With the Development and Severity of Oral Mucositis
Our study intends to evaluate prospectively the incidence and severity of oral mucositis in patients undergoing high-dose chemotherapy and hematopoietic stem cell transplantation, as well as to evaluate the potential influence of…
- Trial name
- NCT00575809
- Testing
- Mucositis and nutritional assessments
- Where
- 2 sites in United States
- Volunteers
- 633 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Mucositis
Oral Zinc Therapy for the Prevention of Mucositis
Zinc is an intracellular mineral with important enzymatic cofactor activities for cell membrane stability, DNA and RNA structure. Zinc deficiency is associated with delayed wound healing and immune dysfunction.
- Trial name
- NCT00449592
- Testing
- Zinc
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Oral Mucositis, Hematopoietic Neoplasm
Effectiveness of Extraoral Photobiomodulation in Management of Oral Adverse Effects in Patients Undergoing HSCT
Patients undergoing hematopoietic cell transplantation (HSCT) receive high doses of chemotherapy with or without radiotherapy to eradicate the underlying disease, which induces a series of adverse effects, including in the oral…
- Conditions
- Oral Mucositis, Hematopoietic Neoplasm, Xerostomia, Hyposalivation
- Trial name
- NCT05759975
- Testing
- Photobiomodulation therapy (intraoral), Photobiomodulation therapy (extraoral)
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Federal University of Rio Grande do Sul
Oral Mucositis, Hematopoietic Stem Cell Transplantation (HSCT)
Safety and Efficacy of N-Acetylcysteine Mouthwash in Prevention of Mucositis in HSCT Patients
Oral mucositis (OM) is one of the most frequent complications in patients who undergo HSCT. It not only causes severe discomfort but also affects treatment adherence and increases hospital stays.
- Trial name
- NCT07325383
- Testing
- N-Acetylcysteine 600mg/tab
- Where
- Iran
- Volunteers
- 106 people
- Sponsor
- Tehran University of Medical Sciences
Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission
Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant
This randomized phase III trial is studying how well Caphosol rinse works in preventing mucositis in young patients undergoing autologous or donor stem cell transplant.
- Conditions
- Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission, Childhood Chronic Myelogenous Leukemia, Childhood Myelodysplastic Syndromes
- Trial name
- NCT01305200
- Testing
- supersaturated calcium phosphate rinse, questionnaire administration, quality-of-life assessment
- Where
- 35 sites in United States, Australia and 1 more
- Volunteers
- 226 people
- Sponsor
- Children's Oncology Group
Multiple Myeloma, Plasma Cell Neoplasm
Ice Chips or Saline Mouth Rinse in Reducing or Preventing Mucositis in Patients Receiving Melphalan and Autologous Stem Cell Transplant for Multiple Myeloma
RATIONALE: Chemoprotective agents may protect normal cells from the side effects of chemotherapy. Ice chips or saline mouth rinse may lessen the severity or help prevent symptoms of mucositis or mouth sores in patients receiving…
- Trial name
- NCT00118339
- Testing
- chemoprotection, complementary or alternative medicine procedure, management of therapy complications
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Fred Hutchinson Cancer Center
Mucositis
Use of Chamomilla Recutita in Mucositis
To determine the Chamomilla recutita solution dose needed to reduce the intensity and evolution time of oral mucositis in adult subjects submitted to HSCT.
- Trial name
- NCT01341054
- Testing
- mouthwash with Chamomilla, Standard oral care protocol
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Oral Mucositis
Tocopherol is a Novel Treatment for Cancer Related Mucositis
The present protocol is an attempt to prevent/treat mucositis in highly susceptible patients subjected to maximally tolerated doses of subsequently-myeloablative or myeloablative doses of chemoradiotherapy supported by autologous…
- Trial name
- NCT00162526
- Testing
- Tocopherol
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Oral Mucositis
A Pilot Study of Efficacy of Lactobacillus CD2 Lozenges in Preventing High-dose Chemotherapy Induced Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation
Patients with various malignancies who are taken up for high dose chemotherapy followed by stem cell transplant (blood and marrow transplant) have very high chances of developing severe oral mucositis (between 95-100%).
- Trial name
- NCT01480011
- Testing
- lactobacillus CD2 lozenges
- Where
- India
- Volunteers
- 31 people
- Sponsor
- All India Institute of Medical Sciences