Clinical trials: Oral Potentially Malignant Disorders
Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders
Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer Triage
This research study evaluates an experimental, point-of-care tool that combines Deep Ultraviolet (DUV) light imaging with Artificial Intelligence (AI) to rapidly screen for oral cancer and pre-cancer (dysplasia).
- Conditions
- Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Cancer
- Trial name
- DEEP UV-M (NCT07842211)
- Testing
- Deep UV-M and AI Cytology Triage
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Anh Le
Oral Squamous Cell Carcinomas, Oral Potentially Malignant Disorder
Heterogeneity of Oral Carcinogenesis: From PrEneoplasia to Invasive Squamous Cell Carcinoma
The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and OPMD) counterparts by scRNAseq in OSCC patients.
- Trial name
- HOPES (NCT07579507)
- Testing
- Biospecimen, Blood sampling
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Leon Berard
Oral Potentially Malignant Disorders, Oral Cavity Squamous Cell Carcinoma
Artificial Intelligence for the Diagnosis of Oral Lesions
Squamous cell carcinomas of the upper aerodigestive tract are among the most common cancers worldwide, with the oral cavity being the most frequent site.
- Trial name
- AID-OraL (NCT07529769)
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography
This clinical trial aims to assess the efficacy of Optical Coherence Tomography (OCT) in the early diagnosis of oral cancer. It focuses on Oral Potentially Malignant Disorders (OPMDs) as precursors to Oral Squamous Cell Carcinoma…
- Conditions
- Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder, Oral Leukoplakia, Proliferative Verrucous Leukoplakia
- Trial name
- SYMILIS OCT (NCT06321003)
- Testing
- OCT (Optical Coherence Tomography)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Cancer Screening, Oral Cancer
Application and Validation of a Smartphone-based Deep Learning System for Oral Potentially Malignant Disorders and Oral Cancer Screening
The goal of this clinical trial is to learn if smartphone-based deep learning system works to accurately detect oral potentially malignant disorders and oral cancer in adults.
- Conditions
- Cancer Screening, Oral Cancer, Oral Potentially Malignant Disorders
- Trial name
- NCT06862414
- Testing
- Smartphone-based deep learning system
- Where
- Taiwan
- Volunteers
- 954 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Oral Potentially Malignant Disorders, Alcohol Drinking
Role of the Dentist in the Control of the Alcoholic Habit in Patients with Potentially Malignant Oral Lesions
Introduction: Alcohol is the most consumed psychoactive substance, its consumption is very prevalent and there is a low perception of the risk it poses in our society.
- Trial name
- ALCODENT (NCT04584333)
- Testing
- Brief intervention
- Where
- Spain
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
NBI for Early Diagnosis of OPMD/OSCC
Early detection - possibly at its pre-malignant stages (Oral Potentially Malignant Disorders, OPMD) - with periodic surveillance is thus fundamental for limiting disease burden, hopefully reducing the incidence of advanced stages…
- Trial name
- NBI_Oral (NCT06438939)
- Testing
- Biopsy for diagnostical purposes
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Cardarelli Hospital
Oral Potentially Malignant Disorders, Oral Cancer
Predictive Value of GOCCLES® Device for Early Diagnosis of Oral Potentially Malignant Disorders
Oral potentially malignant disorders (OPMDs) are chronic pathologies which can suffer dysplastic alterations and evolve into oral cancer.
- Trial name
- NCT05562375
- Testing
- GOCCLES, Toluidine blue stain, Biopsy
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Universidad Rey Juan Carlos
Oral Potentially Malignant Disorder, Oral Cancer
The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma
The mortality rate of oral cancer in Taiwan is still high with no decrease. One of the reasons result in these situations is the patent visits hospital for treatment in late stage of oral cancer.
- Conditions
- Oral Potentially Malignant Disorder, Oral Cancer, Malignant Disorder, p62/SQSTM1
- Trial name
- p62/SQSTM1 (NCT01946230)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital