Clinical trials: Oral Submucous Fibrosis
Submucous Fibrosis
Evaluation of Functional Dimensions of Macintosh Laryngoscope Blade During Direct Laryngoscopy in Patients With Normal Mouth Opening
Direct laryngoscopy and intubation is an essential initial aspect of airway access during general anesthesia. To perform the procedure effectively, it requires adequate mouth opening, head and neck movement, and a normal…
- Trial name
- NCT02639897
- Testing
- Direct Laryngoscopy
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Sir Ganga Ram Hospital
Oral Submucous Fibrosis
Comparison of Curcumin and Intralesional Steroids in Oral Submucous Fibrosis
The goal of this clinical trial is to learn if Curcumin is better than Intralesional Steroid Injection for the treatment of oral submucous fibrosis. The main question it aims to answers are: 1.
- Trial name
- NCT06758739
- Testing
- Curcumin (Turmeric), Intralesional Steroid Injection
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Oral Submucous Fibrosis
Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF)
Curcumin (diferuloylmethane) is the chief component of the spice turmeric and is derived from the rhizome of the East Indian plant Curcuma longa.
- Trial name
- NCT02645656
- Testing
- Curcumin Arm
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer
EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth.
- Trial name
- Sal (NCT07122128)
- Testing
- saliva a a diagnostic tool for early detection of oral cancer
- Where
- Pakistan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Oral Epithelial Dysplasia, Precancerous Conditions
Oral Epithelial Dysplasia Informational Needs Questionnaire
Background: Oral epithelial dysplasia (OED) is a condition with an increased risk of oral cancer. Due to the current changes in the factors associated with these diseases (because of human papillomavirus), it is expected that…
- Conditions
- Oral Epithelial Dysplasia, Precancerous Conditions, Precancerous Lesions, Oral Lichen Planus
- Trial name
- ODIN-Q (NCT04153266)
- Testing
- No intervention is planned for this study
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Oral Submucous Fibrosis
Use of Single Staged Nasolabial Flap in Oral Submucous Fibrosis
Long standing oral submucous fibrosis(OSMF) is associated with involvement of the oral submucosa and the muscles of mastication leading to difficulty in mouth opening.
- Trial name
- NCT02711046
- Testing
- single stage nasolabial flap
- Volunteers
- 11 people
- Sponsor
- Government College of Dentistry, Indore
Oral Submucous Fibrosis
Epithelial Mesenchymal Transition Markers in OSMF
Oral Sub mucous Fibrosis (OSMF) is essentially an imbalance between collagen metabolism and wound healing mechanism induced by arecanut chewing habit.
- Trial name
- NCT03732872
- Testing
- Biopsy tissue analysis, Saliva analysis
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Oral Submucous Fibrosis
Alternating Triamcinolone and Platelet-Rich Plasma Therapy for Oral Submucous Fibrosis
Oral Submucous Fibrosis (OSF) is a chronic, progressive, potentially malignant disorder characterized by mucosal stiffness, trismus, and burning sensation.
- Trial name
- RegenOSF (NCT07277998)
- Testing
- Platelet-Rich Plasma (PRP) Injections, Triamcinolone Acetonide
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Karachi Medical and Dental College
Oral Submucous Fibrosis
Comparative Effect of Nigella Sativa and Conventional Management for OSMF
Oral submucous fibrosis (OSMF) is a potentially malignant condition mainly characterized by inflammation and fibrosis of the submucosal tissues leading to marked rigidity and reduced opening of the jaws.
- Trial name
- NCT04476420
- Testing
- Nigella sativa oil, Betamethasone Valerate
- Where
- Pakistan
- Volunteers
- 39 people
- Sponsor
- Ziauddin University
Oral SubMucous Fibrosis
Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study
Oral submucous fibrosis is a chronic, insidious disease caused by arecanut use and is associated with both significant morbidity (including burning sensation and reduced oral opening) and an increased risk of malignancy.
- Trial name
- NCT02714543
- Testing
- aloevera juice, Hydrocortisone, Hyaluronic Acid
- Volunteers
- 74 people
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Oral Submucous Fibrosis
Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis
The etiology of OSMF is considered to be multifactorial. However, Role of autoimmunity had been suggested as one of the factors but remains unproven.
- Trial name
- NCT03011086
- Where
- India
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Oral Submucous Fibrosis
Efficacy of Curcumin in Oral Submucous Fibrosis
The purpose of the study is to determine whether the formulations of curcumin will effect the clinical signs and symptoms and histopathological features in patients with clinical stage 2 oral submucous fibrosis (OSMF).
- Trial name
- ECOSMF (NCT03511261)
- Testing
- 10% Curcumin mucoadhesive gel, Curcumin capsules 500mg, 5% curcumin mucoadhesive gel + Curcumin capsules 250 mg
- Where
- India
- Volunteers
- 200 people
- Sponsor
- H.K.E.S's S.Nijalingappa Institute of Dental Science and Research
Triamcinolone, Pentoxifylline
Comparison of Triamcinolone With Pentoxifylline and Vitamin- E Efficacy in the Treatment of Stage 2 and 3 Oral Submucous Fibrosis
To compare the efficacy of Triamcinolone with Pentoxifylline and Vitamin E in patients with stage two and three oral submucous fibrosis.
- Conditions
- Triamcinolone, Pentoxifylline, Vitamin E, Oral Submucosa Fibrosis
- Trial name
- NCT05660694
- Testing
- Triamcinolone, Pentoxifylline with Vitamin E
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Oral Submucous Fibrosis
Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis
The goal of this clinical trial is to learn if metformin and antifibrotic drugs (pirfenidone) can modulate fibrosis and improve treatment outcomes in patients with oral submucous fibrosis (OSF).
- Trial name
- "FIBR-MET-PF" (NCT06871904)
- Testing
- Metformin Hydrochloride 500Mg Tablet, Pirfenidone (PFD), Beclomaethasone and Vitamin E
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Ziauddin University
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Submucous Fibrosis
Effect of Laser Photobiomodulation in Improving Mouth Opening in Oral Submucous Fibrosis
This a patient and outcome assessor blinded, multiple arm, randomized placebo controlled clinical trial. The goal of the study is to study the adjunctive effect of 940nm laser photobiomodulation therapy (PBMT) in precancerous…
- Trial name
- OSMFPBMT (NCT06639009)
- Testing
- 940nm diode laser photobiomodulation, Conventional non -Invasive management in Oral Submucous fibrosis
- Where
- India
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Dr. Shalini Gupta
Oral Submucous Fibrosis
Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial
OSF is a widespread health issue in Asian countries, notably Pakistan, linked to the consumption of pan, chalia, and gutka, affecting a rising number of young individuals as an epidemic.
- Trial name
- MROSF (NCT06332612)
- Testing
- Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Ziauddin University
Oral Submucous Fibrosis
Curcumin Plus Topical Steroid Versus Topical Steroid Alone for Oral Submucous Fibrosis
This study evaluates whether combining oral curcumin (a natural compound derived from turmeric) with a topical steroid is more effective than using a topical steroid alone in treating Oral Submucous Fibrosis (OSMF).
- Trial name
- NCT07891130
- Testing
- Curcumin and and triamcinolone acetonide, Triamcinolone Acetonide
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Liaquat College of Medicine and Dentistry