Clinical trials: Oral Surgical Procedures
Peri-Implantitis
Surgical Treatment of Peri-implantitis With and Without an Initial Non-surgical Approach
Randomized, surgeon and outcome assessor blinded, multi-centric, superiority trial with two parallel groups and a 1:1 allocation ratio with the aim of comparing the surgical treatment of severe peri-implantitis with or without an…
- Trial name
- NCT03620331
- Testing
- Surgery with a previous non-surgical approach, Surgery without a previous non-surgical approach
- Where
- 3 sites in Italy, Spain
- Volunteers
- 42 people
- Sponsor
- Universidad Complutense de Madrid
Peri-Implantitis
10 Year Follow-up on Reconstructive Bone Procedures for Peri-implantitis
The purpose of this 10 year observational follow-up study was to evaluate the long-term outcomes of reconstructive surgical treatment of peri-implantitis.
- Trial name
- periimpl10y (NCT07678892)
- Testing
- Treatment with a bone graft and a membrane, Treatment with a bone graft
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Kristianstad University
Healthy Adult Participants, Periodontal Disease
Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis
Although robust evidence supports the benefits of antibiotics in periodontal treatment, the potential adverse effects of this therapy cannot be overlooked.
- Trial name
- NCT07592416
- Testing
- Amoxicilin and Metronidazole, Probiotic Therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Periodontitis, Diabetes Mellitus, Type 2
Effectiveness of Non-surgical Periodontal Treatment on HbA1c Levels in a Patient With Type 2 Diabetes Mellitus
This study evaluates the effectiveness of an intervention, non-surgical periodontal treatment (SPR), in patients with poorly controlled type 2 diabetes mellitus and moderate-severe periodontal disease aimed at reducing HbA1c…
- Trial name
- NCT04051866
- Testing
- Non-surgical periodontal treatment: Scaling and root planing (SRP), Oral hygiene instructions
- Where
- Spain
- Sponsor
- Gerencia de Atención Primaria, Madrid
Wound Healing, Tooth Extraction Site Healing
Effect of Injectable Platelet Rich Fibrin (i-PRF) on Extraction Socket Healing: A Split-Mouth Randomized Study.
The aim of this study is to compare extraction socket healing (SH) following surgical extraction of lower third molars (LTMs) with and without the application of injectable platelet rich fibrine (i-PRF).
- Trial name
- (i-PRF) (NCT07257328)
- Testing
- Surgical extraction of lower third molars.
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontitis
Disease Perception and Oral Health Impact Profile (OHIP) Before and After Non-surgical Periodontal Treatment
The presence of periodontal diseases in patients has been associated to a worsened quality of life overall. Many different indices have been proposed over time in order to evaluate patient's centred outcomes.
- Trial name
- NCT04683016
- Testing
- Questionnaires
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Siena
Edentulism
Accuracy of Metal Sleeve-Free Fully Guided Implant Surgery
This clinical trial aims to evaluate the in vivo accuracy of fully guided dental implant surgery using 3D-printed surgical guides without metal sleeves.
- Trial name
- NCT07364006
- Testing
- Standard Drilling Channel Metal Sleeve-Free Surgical Guide, Reduced drilling channel Metal Sleeve-Free Surgical Guide
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Universidad Complutense de Madrid
Hip Fractures
Early Surgical Fixation of Low-Velocity Hip Fractures in Patients With Direct Oral Anticoagulation
Prospective cohort study on patients with intertrochanteric fractures under direct oral anticoagulation (DOAC) therapy undergoing early surgical fixation (within 24 hours).
- Trial name
- NCT05070169
- Testing
- Early Surgical Fixation vs. Delayed Surgical Fixation
- Where
- Austria
- Volunteers
- 140 people
- Sponsor
- Medical University of Vienna
Periodontitis (Stage 3)
Hydrolyzed Collagen As A Host Modulation Agent in Non-Surgical Periodontal Treatment
This study was planned on the basis of the hypothesis that 'food supplements containing collagen will support the clinical effectiveness of non-surgical periodontal therapy'.
- Trial name
- NCT07683741
- Testing
- Collagen hydrolyzed peptides
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hatice Yemenoglu
Cancer, Solid Malignant Tumors
High-Resolution PET-CT Imaging for Surgical Margin Visualization
Imaging will be exploratory and be used intraoperatively. There have been no discovered risks associated with the device to be used in this study, and none are anticipated given the diagnostic and non-invasive, 'ex vivo' nature…
- Conditions
- Cancer, Solid Malignant Tumors, SCC - Squamous Cell Carcinoma, HNSCC
- Trial name
- NCT06915454
- Testing
- Intra-op PET/CT Specimen Scanner
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Mouth Neoplasms
Tissue Adhesive Versus Sutures in Oral Biopsy Closure
Excisional biopsies are commonly performed in the oral mucosa, and proper wound closure and hemostasis are critical for the success of the surgical procedure.
- Trial name
- NCT07654166
- Testing
- Tissue adhesive (PeriAcryl 90 HV), Surgical suture (Nylon 4-0)
- Where
- Syria
- Volunteers
- 28 people
- Sponsor
- Damascus University
Periodontitis
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures.
- Trial name
- NCT07077122
- Testing
- Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- National and Kapodistrian University of Athens
Stage I Adult Soft Tissue Sarcoma, Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity
EF5 to Evaluate Tumor Hypoxia in Patients With High-Grade Soft Tissue Sarcoma or Mouth Cancer
This laboratory study is using EF5 to evaluate tumor hypoxia in patients with high-grade soft tissue sarcoma or mouth cancer. Using the drug EF5 to measure the oxygen level in tumor cells may help in planning cancer treatment
- Conditions
- Stage I Adult Soft Tissue Sarcoma, Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage II Adult Soft Tissue Sarcoma, Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT00896961
- Testing
- EF5, diagnostic laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Periodontitis
Clinical Effectiveness of Oxygen-Releasing Oral Gel as an Adjunct to Scaling and Root Debridement in Patients With Severe Periodontal Pockets: A Randomized Clinical Trial
The goal of this clinical trial is to learn if adding an oxygen-releasing gel to a deep dental cleaning treatment can improve gum health more than deep cleaning alone, in adults with severe gum disease.
- Trial name
- NCT07840859
- Testing
- Topical oxygen-releasing oral gel, No intervention
- Where
- Malaysia
- Volunteers
- 38 people
- Sponsor
- Universiti Sains Malaysia
Surgical Site Infection, Anastomotic Leak
Oral Antibiotic Prophylaxis in Colorectal Surgery
The investigators perform a case-control study to compare preparation before elective colorectal surgery. The first group is a prospective patient - registry in all patients with mechanical bowel preparation (MBP) and oral…
- Trial name
- ABCR (NCT03759886)
- Testing
- Paromomycin Sulfate Powder
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Velopharyngeal Insufficiency, Velopharyngeal Incompetence Due to Cleft Palate
Expiratory Muscle Strength Training for Hypernasal Speech in Children
When the soft palate does not move enough because of a cleft palate or for unknown reasons, this can lead to a speech difference called velopharyngeal insufficiency.
- Conditions
- Velopharyngeal Insufficiency, Velopharyngeal Incompetence Due to Cleft Palate, Inadequate Velopharyngeal Closure, Palatopharyngeal Incompetence
- Trial name
- NCT05492266
- Testing
- Expiratory Muscle Strength Training, Maintenance Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Noel Jabbour
Intra-bony Pockets, Periodontitis
Biologicals in Management of Intra-Bony Defects
The aim is of this study is to evaluate and compare the effects (clinical and radiological) of different biomaterials on the repair of bone defects around the teeth.
- Trial name
- NCT07292870
- Testing
- Minimally invasive surgical treatment of the intra-bony defects, Use of the xenograft Bio-Oss® Collagen during the surgery, Use of enamel matrix derivative (Emdogain®)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Periodontitis, Smoking Cessation
Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment
Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment
- Conditions
- Periodontitis, Smoking Cessation, Tobacco Dependence
- Trial name
- ENIPT's (NCT07491627)
- Testing
- periodontal non-surgical treatment
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University of Liege
Tongue Cancer, Tongue Cancer TNM Staging Primary Tumor (T) T1
Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers
A prospective multicenter randomized non-inferiority clinical trial, to evaluate the efficacy and safety of 1.0 cm-safety margin surgery, compared with 1.5 cm safety margin surgery for cT1-2N0 oral tongue cancer Summary: A…
- Conditions
- Tongue Cancer, Tongue Cancer TNM Staging Primary Tumor (T) T1, Tongue Cancer TNM Staging Primary Tumor (T) T2, Surgery
- Trial name
- NCT04738786
- Testing
- 1.5 cm surgical safety margin for cT1-2N0 oral tongue cancers, 1.0 cm surgical safety margin for cT1-2N0 oral tongue cancers
- Where
- 4 sites in South Korea
- Volunteers
- 125 people
- Sponsor
- Samsung Medical Center
Periodontal Diseases, Periodontitis, Apical, Chronic Nonsuppurative
Diode Laser Study for Periodontal Maintenance Patients
This study tries to determine whether the additional use of laser with "cleaning" (known as scaling and root planning) will result in the reduction of inflammation, reduction of bleeding upon examination and reduction of pocket…
- Conditions
- Periodontal Diseases, Periodontitis, Apical, Chronic Nonsuppurative, Suppuration of Gingival Crevice
- Trial name
- NCT01215201
- Testing
- Scaling and Root Planing, Diode Laser + Scaling and Root Planing
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Nebraska