Clinical trials: Oral Tumors
Oral Microbiota, Pancreatitis
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
There are more than 700 different bacteria colonized in human oral cavity, which are collectively referred to as oral microbiota.
- Conditions
- Oral Microbiota, Pancreatitis, Pancreatic Cancer
- Trial name
- NCT07015580
- Testing
- 16S rRNA sequencing
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Vaginal Flora Imbalance, ASC-US
"Lactobacillus Crispatus M247, LSIL and Microbiota"
Patients affected by ASC-US/ low-grade HPV cervical lesions will be randomly assigned to treatment arm vs control arm. The treatment arm will include the characterization of the vaginal microbiota at enrollment (T0), 4 months of…
- Conditions
- Vaginal Flora Imbalance, ASC-US, LSIL, HPV Infection
- Trial name
- NCT05808816
- Testing
- Lactobacillus Crispatus M247
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers
Women with a BRCA1 mutation face a lifetime risk of breast cancer of approximately 70% and a lifetime risk of ovarian cancer of approximately 40%.
- Trial name
- NCT01022333
- Testing
- Diindolylmethane (DIM)
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Adjuvant Chemotherapy, Colon Cancer
Modulation of Immune Response by Oral Zinc Supplementation in Chemotherapy for Colon Cancer
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and…
- Conditions
- Adjuvant Chemotherapy, Colon Cancer, Immunity
- Trial name
- NCT01261962
- Testing
- zinc
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Head and Neck Cancer
Cross-Sectional Study of Oral Health in Patients After Parotid-Sparing Radiation Therapy for Head and Neck Cancer
The investigators are conducting research about oral health and saliva to find out more about the impact of radiation therapy on the oral health of patients.
- Trial name
- NCT01663246
- Testing
- Saliva Sample
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Oropharyngeal Cancer, Human Papilloma Virus
Men and Women Offering Understanding of Throat HPV
This study will screen people for oncogenic oral Human Papillomavirus (HPV) infection and antibodies to form a cohort of people who may be at increased risk of HPV-oropharyngeal cancer (HPV-OPC).
- Trial name
- MOUTH (NCT03644563)
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Premalignant Lesion
8-Hydroxy-2-Deoxyguanosine ,Total Antioxidant Capacity in Oral Premalignant and Malignant Lesions
Objectives: Investigating the level of salivary 8-hydroxy-2-deoxyguanosine (8-OHdG) and total antioxidant capacity (TAC) in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant…
- Trial name
- NCT03830710
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Preference, Patient, Pharmacist-Patient Relations
Preferences of Patients Treated With Oral Cancer Drugs and Informal Caregivers for Pharmaceutical Consultation in Hospital
To ensure the safe use of oral anticancer drugs, oncology pharmacy consultations (OPCs) have been established in France. Their goal is to provide the patient with the means to identify, prevent and limit adverse effects and to…
- Conditions
- Preference, Patient, Pharmacist-Patient Relations, Caregiver, Cancer
- Trial name
- IMPLICATION (NCT05970471)
- Where
- France
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
RADICULAR CYSTS
Radicular Cyst Enucleation Using Piezosurgery Versus Conventional Surgery
AIM: The study was intended to evaluate the effectiveness of piezosurgery in enucleation of radicular odontogenic cysts in comparison to the conventional technique from both the clinical and radiographic perspectives.
- Trial name
- NCT04244422
- Testing
- PIEZOSURGERY VERSUS CONVENTIONAL SURGERY
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Advanced Solid Tumor
Effect of Rifampicin on the Pharmacokinetics of HRS-1167 in Healthy Subjects
The primary objective of the study is to evaluate the effect of rifampicin on pharmacokinetics of healthy adult subjects after oral administration of HRS-1167 tablets.
- Trial name
- NCT06198556
- Testing
- HRS-1167 tablets; rifampicin
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Leukoplakia
Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study
Aims: To evaluate the qualitative and quantitative parameters of finger and palmar dermatoglyphic patterns in patients with oral premalignant and malignant lesions OBJECTIVES: 1.
- Trial name
- QQA-FPD-PMML (NCT06256809)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Carcinoid Tumors, Neuroendocrine Tumors
Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion
This is a research study looking at the effect of 5-Hydroxy Tryptophan (5-HTP) on urine excretion of 5-Hydroxyindolacetic acid (5-HIAA).
- Trial name
- NCT00227136
- Testing
- 5-Hydroxy-Tryptamine
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Polycystic Ovary Syndrome
Single Ascending Dose, First-in-Human Study on Safety, Tolerability and Pharmacokinetics of BAY1161116
This study will be conducted in a single center, double-blind with 6 dose escalation groups to evaluate the safety, tolerability, and pharmacokinetics of single ascending doses of BAY1161116.
- Trial name
- NCT03119077
- Testing
- BAY1161116, Itraconazole
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
Immunohistochemical Expression of EGFR in the Patients Having Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is one of the top 10 most common malignancies worldwide. Oral squamous cell carcinoma forms a major health problem in many countries.
- Trial name
- EGFR (NCT06606301)
- Testing
- BioSB EGFR antibody
- Where
- Pakistan
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital, Pakistan
Recalcitrant Cutaneous Warts
Oral Zinc Gluconate as Treatment for Recalcitrant Cutaneous Warts: A Randomized, Double-blind, Placebo-controlled Trial
Up to one-third of common warts can remain recalcitrant, an occurrence that has been attributed to impaired cell-mediated immunity. At present, no guidelines exist for the management of recalcitrant cutaneous warts.
- Trial name
- NCT01783353
- Testing
- Zinc gluconate, Corn starch pill
- Where
- Philippines
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Philippine Dermatological Society
Oral Cancer, Oral Health Knowledge, Attitude and Practice Among Patients
mHealth App for Oral Hygiene and Cancer Awareness in Older Adults
The goal of this clinical trial is to learn whether a mobile app with educational videos and serious games is more effective than a video-only version of the app to improve knowledge, attitudes, and practices about oral cancer…
- Conditions
- Oral Cancer, Oral Health Knowledge, Attitude and Practice Among Patients, Older Adults
- Trial name
- NCT07275411
- Testing
- Mobile Oral Health Education App
- Where
- Chile
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Chile
Mandible Cyst, Mandible Tumor
Bone Lid Technique Versus Standard Technique for Treatment of Mandibular Lesions
Twenty patients with benign mandibular lesion will be included in this study. the patient will be divided randomly (10 patients each group). Group I the lesion will be treated using bone lid technique.
- Conditions
- Mandible Cyst, Mandible Tumor, Mandibular Diseases
- Trial name
- NCT05987930
- Testing
- bone lid technique, standard technique
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tanta University
Cancer
The Effect of Training and Follow-up Given to Cancer Patients Receiving Chemotherapy According to the Neuman Systems Model on the Development of Oral Mucositis and Perceptions of Comfort in Patients
It is aimed to prevent the development of oral mucositis or to reduce the severity of developing oral mucositis with the training to be given to patients receiving chemotherapy according to the Neuman systems model.
- Trial name
- NCT05991544
- Testing
- Training and Follow-up According to the Neuman Systems Model
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Ataturk University