Clinical trials: Organ Donor
Tissue and Organ Procurement, Health Behavior
Community Trial to Enhance Organ Donation
The purpose of this study is to determine the effect of a 5-minute video intervention regarding organ donation and transplantation on increasing the number of organ donor cards signed in Northeastern Ohio Bureau of Motor Vehicles…
- Trial name
- NCT00870506
- Testing
- video
- Where
- United States
- Volunteers
- 973 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Organ Donation
Investigating Affective Attitude Question-behaviour Effects on Intention to Become an Organ Donor
The investigators aim to experimentally manipulate presence of questions on positive or negative affective attitudes to see if including these moderate as intention to become an organ donor.
- Trial name
- NCT02825862
- Testing
- Question-behaviour effect (for affective attitudes), Question-behaviour effect (negatively-worded attitudes)
- Where
- 4 sites in India, Ireland and 2 more
- Volunteers
- 999 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
CMV Infection, EBV
Partially HLA-matched Third Party Antigen Specific T-cells for Infection Post-stem Cell or Solid Organ Transplantation
To assess the safety and biological efficacy of therapeutically administered most closely HLA-matched third party donor-derived specific cytotoxic T lymphocytes (CTLs) targeting cytomegalovirus (CMV) or Adenovirus (Adv) or…
- Conditions
- CMV Infection, EBV, Adenovirus
- Trial name
- R3ACT (NCT02779439)
- Testing
- Virus specific CTLs
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Graft Rejection, Transplantation
Regenerative Cellular Therapies, Physiology, Pathology and Developmental Biology
This study aims to use tissue from deceased organ donors to investigate organ physiology, developmental biology, as well as the development of future regenerative cellular therapies.
- Conditions
- Graft Rejection, Transplantation, Diabetes Mellitus
- Trial name
- RCT (NCT02469207)
- Testing
- Removal of tissue post-mortem
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Organ Donation, Donor Designation/Registration
Health Promoters and Organ Donation
Older Hispanics (age 50+ years) are disproportionately overrepresented on the transplant waitlist, but underrepresented as deceased donors and transplant recipients.
- Trial name
- PdD (NCT04007419)
- Testing
- Health Promoters and Organ Donation
- Where
- United States
- Volunteers
- 621 people, healthy volunteers welcome
- Sponsor
- Temple University
MicroRNA Profile, Liver Transplant
MicroRNA Profile As a Biomarker of Liver Damage in Different Types of Liver Donors.
The goal of this observational study is to analyze the expression of liver-derived miRNAs in different types of liver donors to gain in depth knowledge about distinctive physiologic features within donors and find potential…
- Conditions
- MicroRNA Profile, Liver Transplant, Organ Donor
- Trial name
- NCT06611046
- Testing
- organ donor
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mar Dalmau
Organ Preservation, Liver Transplantation
Long-term Outcomes After Hypothermic Oxygenated Machine Perfusion of Donor Livers Using Real-world Data
End-ischemic hypothermic oxygenated machine perfusion (HOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary…
- Conditions
- Organ Preservation, Liver Transplantation, Hypothermic Machine Perfusion
- Trial name
- HOPE-REAL (NCT05520320)
- Testing
- Hypothermic oxygenated machine perfusion (any device)
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Organ Transplants
RCT Comparing Tailored Versus Targeted Organ Donation Video Education
The primary purpose of this 3-phase mixed methods design study is to investigate how presenting content at varying levels of audience specificity (generic, targeted, and tailored) influences organ donor registration behavior…
- Trial name
- NCT02676102
- Testing
- Control Group, Targeted Intervention, Tailored Intervention
- Where
- United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pain, Postoperative, Nausea and Vomiting, Postoperative
Relieving Surgical Pain and Nausea With Light Therapy
The goal of this clinical trial is to investigate the effectiveness of colored (green and blue lens) glasses as a non-pharmacological method in relieving post-surgical pain and postoperative nausea in kidney donors.
- Trial name
- LITENS (NCT06772519)
- Testing
- green colored lens glasses, blue colored lens glasses, colorless (transparent) lens glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nuran Ayşen Pamir Aksoy
Living Liver and Kidney Donors
Living Organ Donor Recovery Enhancement Program
The purpose of the study is to test if using these living donor-specific pre-transplant resources would lead to a better and faster recovery post-transplant.
- Trial name
- NCT03865264
- Testing
- Recovery Enhancement Program
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Organ Donation, Registration for Deceased Organ Donation
Promoting Organ Donor Registration in Family Physician Offices
This study evaluates the effects of using reception staff to prompt patients by providing a pamphlet and an opportunity to register in the waiting room via a mobile tablet on deceased organ donor registration rates.
- Trial name
- NCT03213171
- Testing
- Reception staff providing handout., Mobile Tablet (e.g. iPad)
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Anatomical Description
Study of the Brain's Natural Cleaning System in Potential Organ Donors.
Alzheimer's disease is a condition that affects the brain and is associated with the build-up of waste substances that can damage brain cells.
- Trial name
- ICGBRAIN (NCT07682155)
- Testing
- Indocynanine Green meningeal injection to understand anatomical connection from the meningeal lymphatic system to the cervical lymph nodes
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Germans Trias i Pujol Hospital
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Cytomegalovirus
Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT
This trial studies the side effects and how well allogeneic cytomegalovirus-specific cytotoxic T lymphocytes (donor cytomegalovirus [CMV] specific cytotoxic T-lymphocytes [CTLs]) or allogeneic adenovirus-specific cytotoxic T…
- Conditions
- Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Cytomegalovirus, Donor, Solid Organ Transplantation Recipient
- Trial name
- NCT03665675
- Testing
- Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes, Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sumithira Vasu
Tissue and Organ Procurement, Alcohol Abstinence
Intervention to Motivate Teens to be a Designated Organ Donor on Driver's License
This study will test the effectiveness of a multimedia campaign to educate ethnic minority teens about the choice to become a designated organ donor on their first driver's license.
- Trial name
- Idecide (NCT00810901)
- Testing
- Organ Donor, Alcohol Prevention
- Where
- United States
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Organ Donor Registration, Organ Donation Education
Increasing Donor Designation Rates in Teenagers: Effectiveness of a Driver's Education Intervention
Four aims were pursued: (1) Evaluate the effectiveness of video messaging on adolescent donor designations in comparison to a regionally-matched historical comparison group of adolescents; (2) Compare the differential…
- Trial name
- NCT03013816
- Testing
- Organ Donation Education: Testimonial Messaging, Organ Donation Education: Informational Messaging, Organ Donation Education: Blended Messaging
- Where
- United States
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Tissue and Organ Procurement
Online Intervention for ANHPI College Students
Taking advantage of college students' frequent use of online technology, including social networking sites (e.g., Instagram a social media site /Facebook a social networking site) and social media sites (e.g., YouTube), the…
- Trial name
- iDecide (NCT02318849)
- Testing
- Web intervention
- Where
- United States
- Volunteers
- 4,827 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
End Stage Renal Disease, End Stage Liver Disease
Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors
This study utilizes a web-based application to help patients on the organ transplant waitlist communicate patient's need for a living donor via social media and provide interested potential donors the opportunity to engage with…
- Trial name
- NCT03803423
- Testing
- The Donor App
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sickle Cell Disease
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease
This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease.
- Trial name
- NCT05384756
- Testing
- Alemtuzumab, Hematopoietic Cell Transplantation, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
COVID-19, Organ Transplant
Immune Registry for Organ Transplantation From COVID Positive Donors.
The purpose of this study is to collect data generated by standard clinical practice to determine the short term and long term clinical outcomes of recipients of solid organ transplantation from COVID-19 infected donors and…
- Trial name
- NCT05595837
- Testing
- Standard organ transplant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Brain Death
Thyroxine Replacement in Organ Donors
To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration
- Trial name
- NCT00238030
- Testing
- L-thryoxine, iv thryoxine
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's