Clinical trials: Organ Dysfunction
Scleroderma, Systemic
The Benefit of Bermekimab in Patients With Systemic Sclerosis
This is a proof-of concept RCT trying to generate evidence that inhibition of IL-1α through the administration of bermekimab may inhibit progression of SSc.
- Trial name
- NCT04045743
- Testing
- MABp1 (Bermekimab)
- Where
- 2 sites in Greece
- Volunteers
- 20 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Multi-Organ Disorder
Pulsed RF Neuromodulation and Leukocyte-Rich PRP for Refractory Low Back Pain
This clinical trial aims to check the safety and efficacy profile of pulsed radiofrequency (RF) neuromodulation combined with leukocyte-rich platelet-rich plasma (PRP) injections for the treatment of refractory low back pain due…
- Trial name
- Multifidus (NCT06524531)
- Testing
- Pulsed RF Neuromodulation, Leukocyte-Rich PRP Injection, Physiotherapy Alone
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Iffat Anwar Medical Complex
COVID, Shock
Endothelial Function, Inflammation and Organ Dysfunction in COVID-19
COVID-19 is a rapidly evolving pandemic with approximately 5% of all patients which require intensive care unit admission. In critically ill patients infected with COVID-19, approximately 15% had severe shock requiring…
- Trial name
- NCT04408365
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Septic Shock, Inflammation
Pharmacology of Exenatide in Pediatric Sepsis
Pharmacology of Exenatide in Pediatric Sepsis, PEPS is a phase 1-2 research study that will examine drug safety, drug metabolism, drug action and preliminary drug clinical effects of four does of exenatide injected every 12 hours…
- Conditions
- Septic Shock, Inflammation, Glucose Homeostasis, Organ Dysfunction
- Trial name
- PEPS (NCT01573806)
- Testing
- Exenatide, Exenatide vehicle
- Where
- United States
- Sponsor
- Seattle Children's Hospital
Sepsis, Infection
The Extended Study of Prevalence of Infection in Intensive Care IV
The goal of this observational study is to learn how common infections are in intensive care units (ICUs) around the world and how they are treated. The study will look at all adults in the ICU during a single 24-hour period.
- Trial name
- EPIC IV (NCT07309549)
- Volunteers
- 10,000 people
- Sponsor
- Universidad de la Sabana
Lung Transplant Rejection
Macitentan in the Treatment of Organ Rejection After Lung Transplantation
Potential therapy with MACITENTAN in the treatment of Chronic Lung Allograft Dysfunction (CLAD) after Lung Transplantation. Pilot Study, Double-blind, "ADD-ON Therapy" with MACITENTAN to "usual standard of care immunosuppressive…
- Trial name
- NCT02893176
- Testing
- macitentan
- Where
- United States
- Sponsor
- University of California, Los Angeles
Organ Donation, Liver Transplantation
EPI-STORM: Cytokine Storm in Organ Donors
Kidney and liver transplantation are the treatment of choice and are often the last therapeutic option offered to patients with chronic renal and liver failure.
- Conditions
- Organ Donation, Liver Transplantation, Kidney Transplantation, Graft Dysfunction
- Trial name
- EPI-STORM (NCT03786991)
- Testing
- No intervention
- Where
- 4 sites in Canada
- Volunteers
- 105 people
- Sponsor
- Université de Sherbrooke
Methylprednisolone, Glucocorticoid
Glucocorticoids for Post-operative Patients With Acute Type A Aortic Dissection (The GLAD Trial)
This study is designed to evaluate the effects of glucocorticoid(GC) on improving post-operative organ dysfunction in patients with acute type A aortic dissection(aTAAD).
- Conditions
- Methylprednisolone, Glucocorticoid, Aortic Dissection, Organ Dysfunction
- Trial name
- NCT05329740
- Testing
- Methylprednisolone Injection
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Multiple Organ Dysfunction Syndrome
Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection
Multiple organ dysfunction syndrome (MODS) after surgical repaire for acute type A aortic dissection(ATAAD) is a life-threatening condition.
- Trial name
- NCT03552848
- Testing
- MSC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Terminal Liver Disease, Ischemia Reperfusion Injury
TOP-Study (Tacrolimus Organ Perfusion): Treatment of Ischemia Reperfusion Injury in Marginal Organs With an ex Vivo Tacrolimus Perfusion
Utilisation of extended criteria donors due to critical organ shortage contributes to increased ischemia reperfusion injury as well as mortality following liver transplantation.
- Conditions
- Terminal Liver Disease, Ischemia Reperfusion Injury, Graft Dysfunction, Graft Failure
- Trial name
- TOP (NCT01564095)
- Testing
- Tacrolimus
- Where
- 7 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Acute Aortic Syndrome, Aortic Dissection Type A
Protective Effect of Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS).
- Trial name
- PANDA (NCT05339529)
- Testing
- Thymosin Alpha1, 28A-Glycine-28B-L-Arginine-28C-L-Glutamic Acid-28D-L-Alanine-28E-L-Proline-28F-L-Alanine-28G-L-Asparagine-, Blank control
- Where
- 15 sites in China
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University
Chagas' Disease (Chronic) With Other Organ Involvement
Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic Presentation
Chagas disease is one of the most neglected vector-borne infectious disease worldwide. The first decades following the discovery of the pathology drove an international research enthusiasm, mainly concentrated on understanding…
- Trial name
- NCT03189056
- Testing
- Chagas serology, Creatinina, Urodynamic exploration
- Where
- Bolivia
- Volunteers
- 152 people
- Sponsor
- Institut de Recherche pour le Developpement
Cardiovascular Disease
Protective Effect of CoQ10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiovascular Surgery (PANDA V)
Cardiovascular diseases are the leading causes of death and prescription drug use. Research on certain dietary supplements looks promising as a way to help reduce risk factors.
- Trial name
- PANDA (NCT04444349)
- Testing
- Coenzyme Q10, Standard Medical Therapy
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Sepsis Syndrome, Sepsis
Mitochondrial DNA as a Biomarker of Sepsis Severity
Mitochondria are organelles (a specialized subunit of a cell) responsible for providing cells with energy. For reasons not yet understood, mitochondria will release their DNA into blood in response to cellular injury or cell…
- Conditions
- Sepsis Syndrome, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- MBOSS (NCT03077672)
- Where
- 2 sites in United States
- Volunteers
- 1,304 people
- Sponsor
- Weill Medical College of Cornell University
Pelvic Organ Prolapse, Sexual Dysfunction
The Association of Pelvic Organ Prolapse Severity and Urinary Symptoms and Sexual Function
Women with pelvic organ prolapse often accompany with urinary symptoms or sexual dysfunction, and analyzing the association will be helpful to identify the indication of proper management.
- Conditions
- Pelvic Organ Prolapse, Sexual Dysfunction, Lower Urinary Tract Symptoms
- Trial name
- NCT01776580
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sepsis
Effect of Adjunctive Ursodeoxycholic Acid on Oxidative Stress, Inflammation, and Organ Dysfunction in Adults With Sepsis
epsis is a life-threatening syndrome characterized by acute organ dysfunction resulting from a dysregulated host response to infection.
- Trial name
- NCT07852780
- Testing
- Standard medical treatment, Ursodeoxycholic Acid
- Volunteers
- 80 people
- Sponsor
- Tanta University
Sepsis-Associated Organ Dysfunction, RTT
CRRT Timing in Sepsis-associated AKI in ICU
Sepsis continues to be a major global cause of both mortality and morbidity. Furthermore, the development of acute kidney injury (AKI) in sepsis increases the risk of unfavorable outcomes.
- Trial name
- CRTSAKI (NCT03175328)
- Testing
- continuous renal replacement therapies
- Where
- 2 sites in China
- Volunteers
- 460 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Hematopoietic Cell Transplantation
A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).
This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impact of endotheliopathies in the…
- Trial name
- NCT05090345
- Testing
- Biorepository Trial
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Pelvic Organ Prolapse, Sexual Function Abnormal
Four-arm Mesh for Vaginal Stump Prolapse
To estimate the safety and efficacy of performing modified anterior transvaginal mesh surgery using polypropylene mesh for treatment of advanced urogenital prolapse after hysterectomy (stage III and IV vc Pelvic Organ Prolapse…
- Trial name
- NCT03809806
- Testing
- 4-arm polypropylene mesh surgery, The Female Sexual Function Index (FSFI) questionnaire, King Health Questionnaire (KHQ)
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Lublin