Clinical trials: Organ Failure
Pancreatitis, Organ Failure, Multiple
PROOF: Pancreatitis-associated Risk Of Organ Failure
This is a prospective case control study that compares the initial immune response with severity and outcome in patients with acute pancreatitis.
- Trial name
- PROOF (NCT03075605)
- Volunteers
- 723 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Malignant Neoplasm, Unspecified Adult Solid Tumor, Protocol Specific
Imatinib Mesylate in Treating Patients With Advanced Cancer and Kidney Failure
Phase I trial to determine the dose of imatinib mesylate that is most effective with the least amount of toxic side effects in treating patients who have advanced cancer and kidney failure.
- Trial name
- NCT00026169
- Testing
- imatinib mesylate, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- National Cancer Institute (NCI)
Multi Organ Failure
Infusion of Prostacyclin vs Placebo for 72-hours in Trauma Patients With Haemorrhagic Shock Suffering From Organ Failure
A multicenter, randomized (1:1, iloprost: placebo), placebo controlled, blinded, investigator-initiated phase 2b trial in trauma patients with haemorrhagic shock and shock induced endotheliopathy (SHINE), investigating the…
- Trial name
- SHINE-TRAUMA (NCT03903939)
- Testing
- Iloprost, Isotonic saline
- Where
- 5 sites in Denmark, Norway
- Volunteers
- 228 people
- Sponsor
- Pär Johansson
Bypass Complications
Transcutaneous-Arterial Carbon Dioxide and Microcirculatory Dysfunction
Evaluation of the microcirculation is currently limited. Continual assessment of the tissue carbon dioxide-arterial carbon dioxide (PtC02-aCO2) offers a new, novel and noninvasive method of determining the state of the…
- Trial name
- NCT02328846
- Sponsor
- University of Virginia
Acute on Chronic Liver Failure, Multiple Organ Failure
Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF
The goal of this clinical trial is to test the MEX-CD1 hemodialysis medical device in patients suffering from ACLF. The main questions it aims to answer are: Is the device safe when used according to the instructions for use?…
- Trial name
- MexACLF (NCT06340269)
- Testing
- MEX-CD1 Dialysis
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- Mexbrain
Autonomic Nervous System Dysfunction in Critically Ill
Transplanted-like Heart in Critical Ill Patients
The purpose of this study is to measure the dysfunction of the autonomic nervous system in modulating the heart rate variability and baroreflex control in critically ill.
- Trial name
- NCT01930669
- Testing
- Gravitational sympathetic stimulus
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Multiple Organ Dysfunction Syndrome
The Prognostic Assessment of Extubation in Aged Patients With Multiple Organ Dysfunction Syndrome
The multiple organ dysfunction syndrome (MODS) has remained the major factor contributing to prolongation of intensive and mortality.
- Trial name
- NCT01802983
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Chinese PLA General Hospital
Critical Illness, Multiple Organ Dysfunction Syndrome
AI-Based Precision Transfusion Prediction Model in Critically Ill Patients
This multicenter observational study aims to develop and validate an artificial intelligence-based precision transfusion prediction model for critically ill patients.
- Conditions
- Critical Illness, Multiple Organ Dysfunction Syndrome, Blood Transfusion
- Trial name
- NCT07762131
- Testing
- Red Blood Cell Transfusion Exposure
- Volunteers
- 2,598 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Disorder Related to Lung Transplantation, Brain Death
Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
- Conditions
- Disorder Related to Lung Transplantation, Brain Death, Graft Failure, Primary Graft Dysfunction
- Trial name
- EVLP_MI (NCT01967953)
- Testing
- EVLP Group
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Policlinico Hospital
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms
- Trial name
- PICSI-H (NCT04283994)
- Testing
- Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 756 people
- Sponsor
- University of Washington
Systemic Inflammatory Response Syndrome, Sepsis
Persistent Multiorgan Failure in Intensive Care Units
Multiorgan failure (MOF) as a result of any critical condition is a complex set of immunological and biochemical interactions leading to death in patients who are effectively subjected to primary resuscitation (correction of…
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Multiorgan Failure
- Trial name
- PROPOSe (NCT03604731)
- Testing
- cytokine adsorbtion during extracorporeal circulation
- Volunteers
- 300 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Congenital Disease
Kids Intestinal Dysfunction in Congenital Heart Disease: the Kind Heart Study
Approximately 40,000 infants are born each year in the United States with congenital heart defects (CHD), and heart defects are the leading cause of birth defect-related deaths in the United States.
- Trial name
- NCT02824705
- Testing
- Congenital Heart Disease Surgery
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Arizona
Kidney Failure, Transplant;Failure,Kidney
Kidney Transplant Outcome and Organ Acceptance Practice Pattern: A Nationwide Analyses in the US and France
Despite the considerable advances in short-term outcomes, kidney transplant recipients continue to suffer from late allograft failure, and little improvement has been made over the past 15 years.
- Trial name
- USFRKT (NCT03723668)
- Where
- 2 sites in United States, France
- Volunteers
- 94,017 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Heart Failure, Respiratory Failure
Donor Simvastatin Treatment in Organ Transplantation
The aim of the study is to investigate the effects of donor simvastatin treatment on ischemia-reperfusion injury after heart transplantation.
- Conditions
- Heart Failure, Respiratory Failure, Liver Failure, Kidney Failure
- Trial name
- SIMVA (NCT01160978)
- Testing
- Simvastatin 80mg, Control Rx
- Where
- Finland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Sepsis
Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis
Hemoadsorption has been demonstrated to improve clinical and paraclinical results in critically ill patients with sepsis and septic shock.
- Trial name
- NCT04533256
- Testing
- CytoSorb
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Institutul Clinic Fundeni
Liver Diseases, Liver Cancer
CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection
This early-phase clinical trial will assess the use of ex vivo CRISPR-Cas9 genome editing on donor liver grafts to reduce immunogenicity before transplantation.
- Conditions
- Liver Diseases, Liver Cancer, Liver Cirrhosis, Liver Failure
- Trial name
- NCT07053488
- Testing
- Ex Vivo CRISPR-Cas9 Gene Editing of Donor Liver
- Where
- China
- Volunteers
- 90 people
- Sponsor
- AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC
Sepsis, Critically Ill
Serum TNF-a in Comparison to Sequential Organ Failure Assessment (SOFA) Score Monitoring in Critically Ill Patients
A total of ninety patients (52men and 38women) were included in the study. Forty five patients developed septic complication during ICU stay (sepsis group).
- Trial name
- NCT01708772
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Multiple Organ Failure
LDH as a Biochemical Biomarker to Predict Organ Failure in the Emergency Department Setting
The purpose of this study is evaluate if K3, a novel biomarker, sampled at arrival to the emergency department can be used to predict the development of organ failure measured as SOFA score.
- Trial name
- NCT01937676
- Where
- Sweden
- Volunteers
- 1,250 people
- Sponsor
- Karolinska Institutet
Multiple Organ Failure
Feasibility Study of MicroKine Dx System in Critically-ill Pediatric Patients.
This study will enroll approximately 25 pediatric patients to assess the performance and real-world feasibility of multi-biomarker based prognostic and predictive algorithms to aid in the clinical management of pediatric…
- Trial name
- NCT04295278
- Testing
- MicroKine Dx system
- Volunteers
- 25 people
- Sponsor
- PreDxion Bio, Inc.
Hypertension, Heart Failure
Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity
The study is aiming to document the long-term safety and effectiveness of renal denervation in patients with hypertension and other diseases characterized by elevated sympathetic drive.
- Conditions
- Hypertension, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- NCT01888315
- Testing
- Renal denervation with Symplicity Flex Medtronic/Ardian, Renal denervation with EnligHTN St. Jude Medical, Renal denervation with Paradise Recor
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Saarland