Clinical trials: Organ Failure
Septic Shock, Sepsis
Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock.
- Trial name
- NCT02266589
- Testing
- Hydrocortisone
- Volunteers
- 84 people
- Sponsor
- Nanjing PLA General Hospital
End-stage Liver Disease (ESLD), Acute Liver Failure
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
Machine perfusion (MP) has become routine clinical practice in liver transplantation. However, as the field has matured, direct randomized comparisons between distinct MP modalities have become increasingly impractical, given…
- Conditions
- End-stage Liver Disease (ESLD), Acute Liver Failure, Liver Cirrhosis, Liver Transplantation
- Trial name
- REFRAME-MP (NCT07585890)
- Testing
- Endischemic hypothermic oxygenated machine perfusion (any device), Endischemic (back-to-base) normothermic machine perfusion (any device), Continuous (device-to-donor) normothermic machine perfusion (any device)
- Where
- 37 sites in Austria, Belgium and 8 more
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Acute Myocardial Infarction, Cardiogenic Shock
Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock
Data from case series and large retrospective trials suggest that the early treatment of cardiogenic shock AMI patients with the association of VA-ECMO and IABP may significantly decrease mortality, which is still unacceptably…
- Trial name
- ANCHOR (NCT04184635)
- Testing
- VA-ECMO
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Renal Failure, SIRS
BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients
The purpose of this study is to find out whether acute renal failure is associated with BK virus reactivation in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- Acute Renal Failure, SIRS, Sepsis, Critically Ill
- Trial name
- BICUK (NCT00736827)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Hepatectomy
The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion
The purpose of this study is to determine whether ketamine is effective to inhibit interleukin 6 synthesis in hepatic resections requiring temporary porto-arterial occlusion.
- Trial name
- NCT00978757
- Testing
- Ketamine
- Where
- Argentina
- Volunteers
- 42 people
- Sponsor
- Hospital Italiano de Buenos Aires
Severe Malaria
Clinical Prediction Models for Pediatric In-Hospital Death Risk in Congolese Severe Malaria Children Using Machine Learning Based-Algorithms
The goal of this observational study is to optimize the management of severe childhood malaria, based on understanding and controlling the severity factors of the disease in Congolese children aged 2 to 9 years (the age group at…
- Trial name
- NCT07355426
- Testing
- Puncture of the radial artery for instant arterial blood gaz as well as for venous biochemistry
- Where
- Democratic Republic of the Congo
- Volunteers
- 100 people
- Sponsor
- University of Kinshasa
Lung Cancer
Determinants of Intensity of Care of Lung Cancer Patients With Organ Failure
Investigators will evaluate determinants of the patients' care type : palliative, medical or intensive care. The place of patient or family on care's decision will be noticed.
- Trial name
- CBP-DO (NCT01999621)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Grenoble
Hemoperfusion, Multiorgan Failure
Hemoperfusion in Critical Patients With Septic Multiorgan Dysfunction Syndrome.
Low-level interventional clinical trial to evaluate the effectiveness and safety of extracorporeal support with hemoperfusion in critical patients with septic multiorgan dysfunction syndrome.
- Conditions
- Hemoperfusion, Multiorgan Failure, Sepsis
- Trial name
- NCT05044403
- Testing
- Extracorporeal support with haemoperfusion, Conventional treatment
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplantation
Prospective Evaluation of Predictors for Organ Failure Following Liver Transplantation
Early organ failure occurs frequently and is difficult to predict. The study aims to define a predictive score for early transplant failure.
- Trial name
- NCT00408889
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University
Sepsis, Acute Respiratory Distress Syndrome
European Registry for Hemadsorption in Sepsis With the Seraph Filter
Although new techniques like extracorporeal blood purification have lately emerged, septic patients still have very high hospital mortality rates. Sepsis can be induced by either viremia, bacteriemia or in some cases both.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Infections - Pathogen Unspecified, Disease
- Trial name
- NCT05608096
- Testing
- Hemoperfusion
- Where
- Croatia
- Volunteers
- 300 people
- Sponsor
- Croatian Society for Organ Support
Lung Transplant Failure
Lung PGD Biomarkers in Organ Donors
PGD is a syndrome characterized by alveolocapillary barrier structural and functional alterations with surfactant inactivation and vascular permeability increase, which cause lung edema, parenchymal infiltrate and progressive…
- Trial name
- NCT03089489
- Testing
- lung biomarkers in organ donor for PGD in lung recipient
- Volunteers
- 50 people
- Sponsor
- University Hospital of Mont-Godinne
Kidney Transplantation, Kidney Disease
Using Donor Stem Cells and Alemtuzumab to Prevent Organ Rejection in Kidney Transplant Patients
Alemtuzumab is a man-made antibody used to treat certain blood disorders. This study will evaluate treatment of kidney transplant recipients with alemtuzumab and other immune system suppressing medications with or without…
- Conditions
- Kidney Transplantation, Kidney Disease, Kidney Failure
- Trial name
- NCT00183248
- Testing
- Alemtuzumab, Mycophenolate mofetil, Sirolimus
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Miami
Multiple Organ Dysfunction Syndrome
6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome
Background: Systemic corticosteroids are considered in patients with an adverse clinical course suffering from conditions like the acute respiratory distress syndrome (ARDS) and septic shock.
- Trial name
- NAIF (NCT00127985)
- Testing
- 6-methyl-prednisolone
- Where
- 6 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Hospital Universitario Principe de Asturias
Sepsis, Multiple Organ Dysfunction Syndrome
The Role of Angiopoietin, Tie-2, and Vascular Endothelial Growth Factor (VEGF) in Sepsis-Induced Multiple Organ Dysfunction Syndrome (MODS)
This study is designated to determine serum concentrations of inflammatory mediators Ang-1, Ang-2, Ang-1/Ang-2 ratio, and Tie-2 in patients with sepsis-induced MODS and to investigate the association among increased permeability…
- Trial name
- NCT00908635
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Hypotension, Brain Injuries
Correlation Between Circulating Biomarkers of Organs Damage and Intraoperative Hypotension Management
Intraoperative hypotension (defined as mean arterial pressure below 65 mmHg) is associated with increased organs dysfunction and mortality.
- Conditions
- Hypotension, Brain Injuries, Renal Failure, Endothelial Dysfunction
- Trial name
- NCT03527758
- Testing
- Flo TracIQ with HPI software
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Catania
Septic Shock
Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure
The purpose of this trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in up to a total of 380 patients with septic shock suffering from…
- Trial name
- COMBAT-SHINE (NCT04123444)
- Testing
- Iloprost, Isotonic saline
- Where
- 6 sites in Denmark
- Volunteers
- 279 people
- Sponsor
- Jakob Stensballe, MD, PhD
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Hypoxemic Respirator Failure and ARDS
There appears to be considerable variability in the approach physicians use to manage arterial carbon dioxide tensions, in patients in the early phases [first 48 hours] of ARDS (Acute hypoxemic respiratory failure and).
- Trial name
- CO2 LUNG SAFE (NCT03415529)
- Where
- Belgium
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- European Society of Intensive Care Medicine
Sepsis in ED Patients
REDS SCORE VERSUS qSOFA SCORE to Predict Mortality in Patients With Suspected Sepsis
Our goal in this work is to compare the predictive accuracy of the REDS score versus qSOFA in identifying in-hospital mortality among ED patients with suspected sepsis and improving outcomes in ED patients.
- Trial name
- NCT07271329
- Testing
- Sphygmomanometer
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Multi Organ Failure, Acute Kidney Injury
Serum Vitamin D Levels in Critically Ill Patients Undergoing Regional Citrate Anticoagulation CRRT
Several studies point at a potential relationship between vitamin D deficiency and worse outcome in critically ill patients admitted to the intensive care unit.
- Trial name
- VitDcrrt (NCT02414386)
- Testing
- biospecimen retention
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Intermittent Fasting, Septic Shock
Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit
This study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in ICU.
- Conditions
- Intermittent Fasting, Septic Shock, Organ Failure, Multiple
- Trial name
- ENNUT-CI (NCT06330610)
- Testing
- Intermittent enteral nutrition
- Where
- France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Rouen