Clinical trials: Organ Perfusion
Non-Alcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis (NASH)
Evaluation of Multi-Organ Metabolism and Perfusion in NAFLD by Total Body Dynamic PET Scan on EXPLORER
Evaluation of Multi-Organ Metabolism and Perfusion in Non-Alcoholic Fatty Liver Disease (NAFLD) by Total Body Dynamic PET Scan on EXPLORER
- Trial name
- EXPLORER (NCT04165343)
- Testing
- Positron Emission Tomography (PET) on EXPLORER, Magnetic Resonance Imaging, Echocardiogram and Electrocardiogram
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Healthy, Lactate Blood Increase
The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain
The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
- Trial name
- NCT06665763
- Testing
- Sodium Lactate Solution
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Organ Preservation, Liver Transplantation
Long-term Outcomes After Hypothermic Oxygenated Machine Perfusion of Donor Livers Using Real-world Data
End-ischemic hypothermic oxygenated machine perfusion (HOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary…
- Conditions
- Organ Preservation, Liver Transplantation, Hypothermic Machine Perfusion
- Trial name
- HOPE-REAL (NCT05520320)
- Testing
- Hypothermic oxygenated machine perfusion (any device)
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Skin Flap Necrosis, Perfusion; Complications
Feasibility of the IC-Flow Device for Fluorescent Perfusion Evaluation During Feasibility of the IC-Flow Device
1. Primary Objective: Demonstrate that the IC-Flow Imaging device with Indocyanine Green (ICG) is a feasible technique when visualizing and identifying perfusion of organs when compared to The KARL STORZ VITOM II ICG System…
- Trial name
- IC-Flow (NCT03860493)
- Testing
- Perfusion evaluation with indocyanine green
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes, Healhty
Insulin-Mediated Glucose Uptake and Organ Perfusion Assessed by Total-Body PET During GIP and GLP-1 Infusion
This study investigates how the naturally occurring gut hormones GIP and GLP-1 influence whole-body glucose uptake and organ perfusion in humans.
- Trial name
- NCT07398300
- Testing
- GIP, GLP-1, Saline (0.9% Sodium Chloride)
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ischemia/Reperfusion Injury
Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against…
- Trial name
- NCT00526695
- Testing
- Sevoflurane (Preconditioning)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich