Clinical trials: Organoids
Infertility, Male, Gene Abnormality
Spermatogonial Differentiation Via Testicular Organoid
Purpose: This clinical trial aims to explore the potential for human sperm production in vitro by sustaining a laboratory-cultured adult testicular environment.
- Conditions
- Infertility, Male, Gene Abnormality, Sterility, Male
- Trial name
- SDTO (NCT06841861)
- Testing
- Stem cell, Genetic Screening, Genetic Reprogramming
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CellARTs Inc.
Intestine Disease
Effect of Antigens or Therapeutic Agents on in Vitro Human Intestinal Organoids
The study evaluates the effect of nutrient antigens or therapeutic agents on human small intestinal organoids.
- Trial name
- NCT03256266
- Where
- Germany
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Gut Inflammation, Hypertension
Gut Organoid and Microbiome Interactions in Hypertension
The study compared basic properties of gut epithelia of hypertensive and normotensive reference subjects. The study determined if there are fundamental differences in the gut epithelium in hypertension compared to normotension.
- Trial name
- NCT04497727
- Testing
- Gene Expression
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometrial Receptivity
Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation
Both controlled ovarian stimulation (COS) and frozen embryo transfer has become an integral part of in vitro fertilization (IVF) treatment.
- Trial name
- HormoSenoRec (NCT06280560)
- Testing
- Controlled Ovarian Stimulation + Luteal Phase Support, Hormonal Replacement Therapy programmed artificial cycle, Natural Cycle (NC)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundación IVI
Primary Sclerosing Cholangitis, PSC
Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients
The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.
- Conditions
- Primary Sclerosing Cholangitis, PSC, Cholangiocarcinoma
- Trial name
- NCT04753996
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastrointestinal Tumors，3D Organoids，Drug Sensitivity
Research on the Correlation Between Organoid Drug Sensitivity Testing and Precise Treatment of Gastrointestinal Tumors
Study the correlation between in vitro drug sensitivity screening of digestive tract tumor organoids and their clinical efficacy in anti-tumor treatment, evaluate the use of digestive tract tumor organoid drug sensitivity to…
- Trial name
- NCT06332716
- Testing
- Based on diagnostic and treatment guidelines/expert consensus, as well as clinical treatment experience, it is recommended that no more than 9 drugs be used for drug sensitivity testing each time.
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Jianjun Yang,MD
Celiac Disease, Small Bowel Disease
Histomolecular Profiling in Small-Bowel Diseases
This prospective cohort study aims to establish reliable histological reference values for normal small-bowel mucosa, improve histological diagnostic quality in celiac disease, and develop an advanced molecular profile for…
- Conditions
- Celiac Disease, Small Bowel Disease, Refractory Celiac Disease
- Trial name
- Deep Bowel (NCT07556328)
- Where
- 3 sites in Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Cystic Fibrosis (CF), CFTR-related Disorders
A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis
Sometimes it is very difficult to tell if someone has cystic fibrosis (CF), especially when they have rare CF genes. Without this certainty, they are unlikely to get the correct treatment so their health may be affected.
- Trial name
- ADVANCE-CFTR (NCT07402434)
- Testing
- Rectal Biopsy, Rectal biopsy taken opportunistically during endoscopy procedure for other reasons., Blood test for CFTR Genotyping
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Irritable Bowel Syndrome, Food Sensitivity
Confocal Laser Endomicroscopy to Determine Influence of Food Antigens on Mucosal Integrity
Irritable bowel syndrome (IBS) is mainly associated with food intolerance and presents a particular challenge in gastrointestinal practice.
- Conditions
- Irritable Bowel Syndrome, Food Sensitivity, Healthy Controls
- Trial name
- RDS_CLE (NCT05056610)
- Testing
- food antigens on duodenal mucosa
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory Bowel Diseases
Intestinal Stem Cells Characterization
A monocentric pilot studying intestinal organoids from endoscopic biopsies of IBD (Crohn and ulcerative colitis), FAP patients and healthy controls.
- Trial name
- BIODIGE (NCT02874365)
- Testing
- Endoscopic biopsies
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
PDAC - Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma
Patients with early pancreatic cancer often have symptoms that could also be caused by many common benign conditions, or no symptoms at all.
- Trial name
- VAPOR (NCT05727020)
- Testing
- Breath test, Collection of matched samples of breath, biofluids and pancreatic tissue
- Where
- United Kingdom
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Circulating Tumor Cell, HNSCC
Using a 3D Culture Model for Circulating Tumor Cells Combined With Molecular Bioassays in Patients With HNSCC Cancer
Cancer has been a significant cause of human death in the recent two decades, although detection, diagnosis, and cancer treatments improved and evolved rapidly.
- Trial name
- NCT06755762
- Testing
- Organoid 3D culture
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Food Allergy, Food Hypersensitivity
Mucosal IgE to Improve Diagnosis of Food Allergy and Food Hypersensitivity
Aim of the study is to improve the diagnosis of food allergy and hypersensitivity. Intestinal homogenates will be used to determine total IgE, specific IgE, tryptase, histamine and inflammation parameters (IFNgamma, TNFalpha).
- Trial name
- NCT05259826
- Testing
- biopsy sampling
- Where
- Germany
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Autism Spectrum Disorder (ASD
Exploring the Physiological Mechanisms of Austism Through Organoids
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting approximately 1% of the population, characterized by difficulties with social interaction and communication.
- Trial name
- EXPECT HYPE (NCT07494331)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endometrial Cancer, Lynch Syndrome
Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome
Study Goal: This pilot study wants to find out if using a menstrual cup can be a good, non-invasive way to collect samples from the lining of the uterus (called the endometrium) to help screen for endometrial cancer.
- Conditions
- Endometrial Cancer, Lynch Syndrome, Screening, Early Detection of Cancer
- Trial name
- SCREEN-CUP (NCT07220239)
- Testing
- Menstrual cup use
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Jessica D. St. Laurent, MD
Organoids
The Innervation of Human Gut Sensory Epithelial Cells
The study has two objectives: 1. To obtain endoscopic and colonoscopic biopsies to harvest and culture intestinal crypts from human tissue to produce organoids.
- Trial name
- NCT02888587
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Duke University
Myasthenia Gravis Generalized
PANORAMA: Neuromuscular Organoids for Refractory AChR+ Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies attack the neuromuscular junction, the site at which nerve cells communicate with muscle fibres, impairing signal transmission and causing fluctuating muscle…
- Trial name
- PANORAMA (NCT07717281)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico