Clinical trials: Orofacial Pain, active
TMD/Orofacial Pain, Fibromyalgia (FM)
Diagnostic and Prognostic Salivary Biomarkers in Chronic Muscle Pain
A large proportion of the adult population worldwide currently lives with chronic muscle pain, with more than half of those affected experiencing pain localized to the face and jaw.
- Trial name
- NCT06994156
- Where
- Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Bruxism
Comparison of the Effects of Different Massage Techniques in Individuals With Bruxism
The aim of this study is to compare the effects of occlusal splint therapy and different massage techniques on pain intensity and orofacial muscle tone and stiffness in individuals with possible sleep bruxism.
- Trial name
- NCT07567183
- Testing
- Connective tissue massage, Classic massage, Occlusal Splint Group
- Volunteers
- 42 people
- Sponsor
- Okan University
Orofacial Pain, Bruxism
Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain
To evaluate the clinical effectiveness of chlorzoxazone in comparison to orphenadrine Citrate in relieving the orofacial pain in bruxers.
- Trial name
- NCT07109882
- Testing
- Chlorzoxazone, Orphenadrine Citrate
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Orthodontic Discomfort, Pain, Orofacial
Comparison of Patient-reported Pain After Initial Archwire Placement
Three different types of 'archwires' can be used in Orthodontic treatment, wire choice is decided by treating Orthodontist based on professional preference since research shows that all types are equally effective.
- Trial name
- Archwires (NCT03906422)
- Testing
- 3M Unitek 0.016 orthodontic archwire, Device: 0.016" Ormco 27oC NiTi orthodontic archwire, Device: 0.016" Ormco 35oC NiTi orthodontic archwire
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Orofacial Pain
Evaluation of the Efficacy of Neuromodulation in the Control of Chronic Orofacial Pain
Chronic orofacial pain significantly affects patients' quality of life, compromising essential functions such as chewing and speech.
- Trial name
- NeuroFace (NCT07352384)
- Testing
- Active Neuromodulation (tDCS or TMS)
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Chronic Orofacial Pain, Temporomandibular Disorder (TMD)
Orofacial Pain Self-management: Personality Moderation Effect
The objective of this clinical trial is to study the effect of self-management on pain perception in patients with chronic orofacial pain and temporomandibular disorders (TMD) comparing it with the conventional treatment proposed…
- Conditions
- Chronic Orofacial Pain, Temporomandibular Disorder (TMD), Temporomandibular Disorders (TMD), Temporomandibular Dysfunction (TMD)
- Trial name
- NCT06932406
- Testing
- Self-management intervention, Clinical Practice Guideline Intervention
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Bruxism
Somatosensory Training Versus Exercise Therapy in Awake Bruxism
Awake bruxism (daytime teeth clenching or jaw tension) is a common condition that can cause jaw pain, facial pain, muscle fatigue, and reduced quality of life.
- Trial name
- NCT07336082
- Testing
- Jaw exercise therapy, Somatosensory Awareness-Based Training, Wait-List Control
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Aydin Adnan Menderes University
Temporomandibular Disorders (TMD), Orofacial Pain
Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders
Dentists and physiotherapists have two options for treating these conditions: splint therapy and physiotherapy. Right now, the gold standard is individual physiotherapy, which contains manual therapy and active exercises too.
- Conditions
- Temporomandibular Disorders (TMD), Orofacial Pain, Temporo-mandibular Dysfunction, Temporomandibular Joint and Muscle Disorder
- Trial name
- NCT07474662
- Testing
- Individual physiotherapy, Group physiotherapy, Online physiotherapy
- Where
- 2 sites in Hungary
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Orofacial Pain
Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain
A prospective, randomized, double-blind clinical trial comparing the safety and efficacy of intravenous lidocaine, ketamine, and their combination as treatment options for patients suffering from treatment-resistant orofacial…
- Trial name
- NCT07250867
- Testing
- Lidocaine Intravenous Infusion, Ketamine intravenous infusion, Combined lidocaine and ketamine intravenous infusion
- Volunteers
- 105 people
- Sponsor
- Assiut University
Burning Mouth Syndrome, Orofacial Pain
Burning Mouth Syndrome: Effects of Occlusal Splint Therapy
Burning Mouth Syndrome (BMS) causes chronic oral pain and significantly affects quality of life. Effective treatments are limited and often provide only temporary relief.
- Conditions
- Burning Mouth Syndrome, Orofacial Pain, Mouth Dryness
- Trial name
- NCT07344909
- Testing
- Essix splint
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Malmö University
Masticatory Myofascial Pain
Effect Of Orofacial Pain Therapy On Bruxism
Bruxism and clenching at night and during the day are considered the most common parafunctions that can influence temporomandibular disorders, including chronic myofascial pain of the masticatory muscles.
- Trial name
- NCT07875738
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Pain, Orofacial
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a…
- Trial name
- NCT04059172
- Testing
- Ibuprofen 200 mg and acetaminphen 650 mg, Ibuprofen 200 mg
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Head Cancer, Neck Cancer
Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)
Following preliminary studies carried out in our department on these subject and subjective findings during clinical examinations, it has been shown that pain is a symptom that is rarely reported following treatment.
- Conditions
- Head Cancer, Neck Cancer, Chronic Pain
- Trial name
- OCAPA (NCT04673981)
- Testing
- diagnostic tes for neuropathic pain
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Myogenic Temporomandibular Joint Disorders, Myofacial Pain
Efficacy of PRP Injections in Reducing Pain for Myogenous TMD Patients
This study aims to evaluate whether intramuscular injections of platelet-rich plasma (PRP) are more effective than isotonic saline in reducing pain and improving jaw function in individuals diagnosed with myogenous…
- Conditions
- Myogenic Temporomandibular Joint Disorders, Myofacial Pain, Masseter Muscle
- Trial name
- NCT07606378
- Testing
- Saline (0.9% NaCl), Platelet rich plasma (PRP)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Persistent Idiopathic Facial Pain (PIFP)
Deciphering Persistent Orofacial Pain - PIFP
Persistent non-dental orofacial pain is common yet poorly characterised, and its pathophysiology remains largely unknown. Two clinically similar entities are distinguished: post-traumatic trigeminal neuropathic pain (PTNP), in…
- Trial name
- NCT07791004
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
TMD, TMD/Orofacial Pain
Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions
The goal of this clinical trial is to learn if orofacial exercises works to treat temporomandibular disorders in adults. It will also learn about the safety of orofacial exercises on temporomandibular disorders.
- Trial name
- NCT07304557
- Testing
- Exercise, Manual therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Tayfun ISIK
Temporomandibular Disorders (TMD)
Aerobic Physical Activity and Orofacial Myofascial Pain
Orofacial myofascial pain, most commonly represented by Temporomandibular Disorders (TMD) a significant public health, affecting approximately 12% to 14% of the general population.
- Trial name
- AERODOF (NCT07526688)
- Testing
- Temporal Summation of Pain and Questionnaire
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Trigeminal Neuralgia (TN), Orofacial Pain
Identification of Possible Trigeminal Neuralgia
Trigeminal neuralgia (TN) is a severe type of non-dental orofacial pain that can feel like sudden electric shocks in the face and is often mistaken for tooth pain or other dental problems.
- Conditions
- Trigeminal Neuralgia (TN), Orofacial Pain, Dental Pain, Questionnaire
- Trial name
- IDTN (NCT07453511)
- Testing
- Completion of the IDTN Questionnaire
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University College, London
Bruxism, Pelvic Floor Disorder
Bruxism and Pelvic Floor Dysfunction in Young Women
Bruxism and Pelvic Floor Dysfunction in Young Women
- Conditions
- Bruxism, Pelvic Floor Disorder, Young Adult Females, Myofascial Pain Dysfunction Syndrome
- Trial name
- NCT07437924
- Testing
- Questionnaire and Physical Exam
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University