Clinical trials: Oropharynx
Radiation-Induced Oral Mucositis (RTOM), Head and Neck Cancer
Sancai Fengsui Decoction for RTOM: A Multicenter RCT
How to promote the prognosis and outcome of RTOM, restore oral function, and improve quality of life are key issues for improving the long-term outcomes of head and neck malignant tumor radiotherapy, and are also integral parts…
- Conditions
- Radiation-Induced Oral Mucositis (RTOM), Head and Neck Cancer, Oral Mucositis of RTOG Grade Greater Than 1
- Trial name
- NCT07692997
- Testing
- Sancai Fengsui Decoction
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Healthy Subjects
Evaluate Retention of an Orally Administered Device Using Gamma Scintigraphy Study 2
Single usage, open label study in up to 40 adult healthy males. Eligible subjects will receive a single usage of the investigational or commercial device.
- Trial name
- NCT00780286
- Testing
- Polymer based lubricating liquid, Moi-Stir
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Head and Neck Cancer, Oropharyngeal Cancer
Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy
The purpose of this study is to investigate the role of the immune system in the response of squamous cell cancers of the head and neck to treatment that includes radiation therapy.
- Conditions
- Head and Neck Cancer, Oropharyngeal Cancer, Human Papillomavirus, Squamous Cell Cancer
- Trial name
- NCT01358097
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Human Papillomavirus Infection
Throat and Other HPV-Related Cancers in Men: Identifying Them Early
This trial studies the screening of human papillomavirus (HPV)-related oropharyngeal and anogenital cancers. Learning the relationship between HPV and cancer risk in men who test positive for HPV antibodies or circulating HPV DNA…
- Trial name
- TRINITY (NCT02897427)
- Testing
- Biomarker Analysis, Biospecimen Collection, Ultrasonography
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Oral Cancer, Chatbot
Enhancing Oral Cancer Awareness
To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention
- Conditions
- Oral Cancer, Chatbot, Patient Education, Prevention
- Trial name
- NCT06682494
- Testing
- Traditional Education, AI-powered Chatbox
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Oropharyngeal Cancer
Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma
Cancer of the oropharynx (middle, side and back walls of the throat; back of the tongue; soft palate, and tonsils), or oropharyngeal squamous cell carcinoma (OPSCC), has been on the rise in the United States.
- Trial name
- NCT02147418
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New Mexico Cancer Research Alliance
Preoxygenation
UMOX - New Device for Oropharyngeal Preoxygenation
The UMOX is a device that has been designed as an alternative to the conventional face mask for preoxygenation to be used when an optimal preoxygenation with a facemask is difficult to achieve(i.e: when a leak is present.
- Trial name
- NCT01018316
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Myotonic Dystrophy 1, Dysphagia, Oropharyngeal
Profile of Dysphagia in Myotonic Dystrophy Type 1 (DM1)
The goal of this observational study is to learn about swallowing difficulties (dysphagia) in patients living with myotonic dystrophy type 1 (DM1).
- Trial name
- SwallowDM1 (NCT05865483)
- Where
- United Kingdom
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University College, London
Dysphagia, Oropharyngeal
The Efficacy of Tongue Exercises on Swallowing Function in the Elderly With Mild Cognitive Impairment
The purpose of this study is to explore the effects of tongue muscle strength and resistance exercises on dysphagia, tongue muscle strength, oral hygiene, repetitive saliva swallowing, nutrition, depression, and…
- Trial name
- NCT06490705
- Testing
- tongue resistance exercises, tongue strengthening exercises and tongue resistance exercises
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Medical Foundation
Stroke
Changes of Swallowing Function and Oropharyngeal Muscle Mass on Sonography After Comprehensive Swallowing Therapy and Neuromuscular Electrical Stimulation in Stroke Patients With Dysphagia
1. The inter-rater and intra-rater reliability of sonography. 2. To explore that sonography is a clinically practical tool for assessing the changes of oropharyngeal muscles mass. 3.
- Trial name
- NCT04728737
- Testing
- swallowing therapy, IOPI therapy, neuromuscular electrical stimulation (NMES) therapy
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Stage II-IVB Operable HNSCC Oral Cavity, Hypopharynx
Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.
This is a phase II randomized, open label study of durvalumab with/ without tremelimumab as neoadjuvant therapy and durvalumab maintenance after SoC RTx with/without cisplatin as post-surgical adjuvant therapy in treatment naïve…
- Conditions
- Stage II-IVB Operable HNSCC Oral Cavity, Hypopharynx, Oropharynx, Larynx
- Trial name
- NCT03737968
- Testing
- Durvalumab, durvalumab + tremelimumab
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Physical Therapy
Feasibility Of Oral Sensorimotor Stimulation On Oropharyngeal Dysphagia In Children With Spastic Cerebral Palsy
Children with CP encounter swallow and feeding impairments, especially in infancy and childhood with long meal times with late development of oral motor skills resulting in poor growth.
- Trial name
- NCT04524559
- Testing
- conventional physical therapy training, oral motor training.
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Gastrointestinal Endoscopy
Application of New Oropharyngeal Airway Management in Obese Patients Undergoing Painless Gastroenteroscopy
Painless endoscopy is a popular method of endoscopic diagnosis and treatment. Propofol combined with fentanyl general intravenous anesthesia has been widely used in painless endoscopic diagnosis and treatment.However, the…
- Conditions
- Obesity, Gastrointestinal Endoscopy, Airway Management
- Trial name
- NCT06590922
- Testing
- Group using new oropharyngeal airway (experimental group), The conventional endoscopic biting group (control group)
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Cervical Intraepithelial Neoplasia, Cervical Cancer
Impact of HPV Vaccine On The Prevalence Of HPV In Norway
The overall aim of the study is to assess the effect of school-based Human Papillomavirus (HPV) vaccination by comparing type-specific HPV prevalence between vaccinated and non-vaccinated women born in 1997.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Oropharyngeal Cancer
- Trial name
- NCT02934724
- Testing
- Self sample from vagina, Self sample from the oral cavity, Questionnaire
- Where
- Norway
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Oropharynx Cancer
Bitter Taste Receptors in Oropharynx Cancer
The aim of this work is to investigate the expression of the bitter taste receptors in p16-positive and negative oropharyngeal carcinomas (in comparison to healthy, local tissue).
- Trial name
- NCT05211427
- Testing
- Biopsy
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Hummel
Xerostomia
Mesenchymal Stemcells for Radiation Induced Xerostomia
The current study aims to assess the safety and feasibility of the injection of autologous adipost tissue derived MSCs on radiation-induced salivary gland hypofunction and xerostomia in head and neck cancer participants.
- Trial name
- MESRIX (NCT02513238)
- Testing
- Mesenchymal stem cell, Isotonic NaCl
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dysphagia, Oropharyngeal
Reference Values for Videofluoroscopic Measures of Swallowing
Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international "gold standard" dysphagia diagnostic exam, there is a…
- Trial name
- NIA_RV (NCT05497219)
- Testing
- Videofluoroscopic Swallowing Study (VF)
- Where
- 5 sites in United States, Canada
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Premature
Pain and Comfort During Endotracheal Suction in Premature Neonates
Most of the preterm babies in neonatal units are followed up with invasive mechanical ventilation support. For this reason, endotracheal suction is needed repeatedly in preterm babies in order to open the airway obstruction…
- Trial name
- NCT05095285
- Testing
- Swaddling, Oropharyngeal colostrum
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Healthy Subjects
Evaluate Retention of an Orally Administered Device Using Gamma Scintigraphy
Single usage, open label study in 16 adult healthy males. Eligible subjects will receive a single usage of the investigational device. Retention of the radiolabeled device will be monitored using gamma scintigraphy.
- Trial name
- NCT00754091
- Testing
- Polymer based lubricating liquid
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Aspiration
The Effect of Body Position on Oropharyngeal Swallow Function in Infants
Infants are typically fed in a cradled, upright position, however feeding specialists/SLPs often position infants in a side-lying position to promote safe, quality, and neurodevelopmentally protective feeding which is supported…
- Trial name
- NCT05874102
- Testing
- Sidelying, Upright
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center