Clinical trials: Orphan Diseases
Gingival Disease Due to Bacteria
Oral Health Status and Diet History Analysis Among Orphan House Children From 10-14 Years in Cairo Governorate.
the purpose of study to determine oral health status and dietary habits among group of orphan children from 10-14 years in Cairo Governorate.
- Trial name
- NCT04167826
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vascular Dysfunction, Genetic Mutations
Vascular Disease Discovery Protocol
Background: Some genetic diseases put increase the risk of heart and blood diseases, which are the number one cause of death and disability in the U.S. Researchers want to study diseases of the heart and/or blood vessels.
- Conditions
- Vascular Dysfunction, Genetic Mutations, Genetic Predisposition
- Trial name
- NCT03538639
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Fragile X Syndrome
CTH120 First-in-Human Study: Single and Multiple Ascending Doses and Potential Food Interaction
The purpose of this First-in-Human Phase I study is to investigate the safety, tolerability and pharmacokinetics of CTH120 in adult healthy volunteers.
- Trial name
- FIH-CTH120 (NCT06480968)
- Testing
- CTH120
- Where
- Spain
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Connecta Therapeutics, S.L.
Dental Caries, Knowledge, Attitudes, Practice
Oral Health Educational Program on Oral Hygiene Knowledge and Practices in a Group of Orphan Children
An orphan is defined as "a child under the age of 18 whose mother, father, both parents, and a primary caregiver has died, and who is in need of care or protection".
- Trial name
- NCT06897956
- Testing
- Oral health educational program
- Where
- Egypt
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orphan Cholestatic Liver Diseases, Progressive Familial Intrahepatic Cholestasis
An Open Label, Single-dose, Single Period ADME Study of A4250 in Healthy Subjects
The primary objectives of the study are to assess the mass balance recovery after a single dose of carbon-14 [14C]-A4250 as a capsule and to provide plasma, urine and faecal samples for metabolite profiling and structural…
- Conditions
- Orphan Cholestatic Liver Diseases, Progressive Familial Intrahepatic Cholestasis, Alagille Syndrome, Primary Biliary Cirrhosis
- Trial name
- NCT03082937
- Testing
- 3 mg [14C]-A4250 capsule
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Albireo
Dental Caries, Orphaned Children
Evaluation of Oral and Dental Health of Institutionalized Orphan Children Residing in Children's Homes in Turkey
Both dental caries prevalence and periodontal status of children residing in children's homes in Sivas province of Turkey were evaluated.
- Conditions
- Dental Caries, Orphaned Children, Periodontal Index
- Trial name
- NCT06725654
- Testing
- Diagnostic Procedures
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Poverty, Orphaned Children
Bridges to the Future: Economic Empowerment for AIDS-Orphaned Children in Uganda
Bridges to the Future: Economic Empowerment for AIDS-Orphaned Children in Uganda, represents the first study that measures medium-term efficacy and cost-effectiveness of a family economic empowerment intervention for…
- Conditions
- Poverty, Orphaned Children, AIDS Orphans
- Trial name
- NCT01447615
- Testing
- Bridges, Bridges PLUS, Usual Care
- Where
- Uganda
- Volunteers
- 1,410 people, healthy volunteers welcome
- Sponsor
- Columbia University
Syndrome X, Takotsubo Cardiomyopathy
Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology
Tako-Tsubo Cardiomyopathy (TTC) and Cardiac Syndrome X (CSX) are respectively acute and chronic cardiac conditions whose clinical presentation, mimicking the onset of acute myocardial ischemia in absence of epicardial coronary…
- Trial name
- ENDAUT (NCT02307214)
- Testing
- BaroReflex Sensitivity, endothelial function measurement
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ospedale San Giovanni Bellinzona
Posttraumatic Stress Disorder, Depression
Narrative Exposure Therapy Versus Group Interpersonal Psychotherapy
The present study is a pragmatic trial that investigates the efficacy and usefulness of two treatment modules in a sample of Rwandan genocide orphans: Narrative Exposure Therapy (NET) versus group-Interpersonal Psychotherapy…
- Conditions
- Posttraumatic Stress Disorder, Depression, Narrative Exposure Therapy, Interpersonal Psychotherapy
- Trial name
- NCT00623298
- Testing
- Narrative Exposure Therapy, group IPT, 6 months-baseline
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Orphan Cholestatic Liver Diseases, Primary Biliary Cirrhosis
A Safety and Pharmakokinetic Study of A4250 Alone or in Combination With A3384
The primary objectives of the study are to evaluate the safety, tolerability and pharmacokinetics of A4250 after single or multiple oral doses in healthy subjects.
- Conditions
- Orphan Cholestatic Liver Diseases, Primary Biliary Cirrhosis, Progressive Familial Intrahepatic Cholestasis, Alagille Syndrome
- Trial name
- NCT02963077
- Testing
- A4250, CRC (A3384), Questran
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Albireo
Depression, Anxiety
Effect of the MindUP Program on Depression, Anxiety, and Stress in Pakistani Orphan Adolescents
This study evaluates the effectiveness of the MindUP mindfulness-based program in reducing depression, anxiety, and stress among orphan adolescents in Pakistan.
- Conditions
- Depression, Anxiety, Stress
- Trial name
- MINDUP-PAK (NCT07468994)
- Testing
- MindUP Program
- Where
- Pakistan
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Quaid-e-Azam University
HIV/AIDS
Bridges2Scale: Testing Implementation Strategies
The goal of this clinical trial is to compare two multifaceted strategies (standard vs enhanced) for scaling Bridges in a two-arm Hybrid III effectiveness-implementation cluster randomized controlled trial (RCT) in adolescent and…
- Trial name
- NCT06347146
- Testing
- Financial Literacy Training (FLT) workshops, Mentorship, Income Generation Activity (IGA)
- Where
- Uganda
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Eczema/Atopic Dermatitis, Cancer
Patient Forward Access to Clinical and Technological Research: Genetic Influences on Cancer and Atopic Dermatitis
This Patient Forward study intends to conduct research to investigate potential genetic factors causing cancer and eczema/atopic dermatitis.
- Trial name
- PFACTR02 (NCT04362852)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Fragile X Syndrome (FXS), Neurotypical Adults
Neural Biomarkers in Fragile X Syndrome
The purpose of this non-interventional test /re-test study is to assess neural biomarkers in adult subjects with Fragile X syndrome compared to those measured in a population of typically developing adults
- Trial name
- EXP-CTH120 (NCT06957054)
- Testing
- Any
- Where
- 2 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Connecta Therapeutics, S.L.