Clinical trials: Orthopedic Injury
Orthopedic Disorder, Anterior Cruciate Ligament Injuries
Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug.
- Trial name
- NCT05461326
- Testing
- Quad tendon, BTB
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Depression
Identifying and Treating Depression in the Orthopaedic Trauma Population
The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1.
- Trial name
- NCT05976347
- Testing
- Fluoxetine 20 MG, Duloxetine 30 MG, Observation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Ankle Fractures, Proximal Humeral Fracture
Orthopaedic Conservative Treatment in the Time of Covid-19 Pandemic
This is a one centered retrospective study. Tendency for surgical interventions in the pre-pandemic period was reduced to protect surgical team and patients.
- Conditions
- Ankle Fractures, Proximal Humeral Fracture, Wrist Fracture
- Trial name
- NCT04623346
- Testing
- Observation for study group
- Where
- Turkey (Türkiye)
- Volunteers
- 262 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Acute Orthopedic Injury
Toolkit for Optimal Recovery After Orthopedic Injury
This is a multi-site randomized feasibility trial of the Toolkit for Optimal Recovery after Orthopedic Injury (TOR), a mind-body program to prevent persistent pain and disability in at-risk patients with acute orthopedic injury…
- Trial name
- TOR (NCT04973696)
- Testing
- Toolkit for Optimal Recovery after Orthopedic Injury, Minimally Enhanced Usual Care (MEUC)
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Massachusetts General Hospital
Hand Injuries, Wrist Injuries
Study of A Long Lasting Local Anesthestic for Hand, Wrist or Finger Surgery
The purpose of this study is to compare Exparel, a new, long-lasting numbing medication and a shorter-acting nerve block to a traditional single-shot nerve block in patients having hand, wrist or finger surgery.
- Conditions
- Hand Injuries, Wrist Injuries, Finger Injuries
- Trial name
- NCT02058303
- Testing
- Exparel Forearm block, Bupivacaine supraclavicular block
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Acute Pain, Fractures
Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
Opioid pain medications such as morphine and dilaudid are commonly used in emergency departments to treat pain in patients. Physicians are familiar with the side effects of these medications; the most concerning of which is…
- Trial name
- NCT02430818
- Testing
- ketamine, morphine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Orthopedic Disorders, Injury of Anterior Cruciate Ligament
Injection Pressure & Adductor Canal Block
This is a prospective, randomized, single-blinded human clinical trial that will examine how injection pressure influences the spread of a given volume of injectate in the adductor canal, during adductor canal nerve block.
- Trial name
- NCT02563990
- Testing
- High Pressure Injection, Low Pressure Injection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hip Fractures (ICD-10 72.01-72.2), Osteoarthritis, Knee and Hip
Population Pharmacokinetics and Pharmacodynamics of Ciprofol
The goal of this observational study is to learn how the anesthetic drug ciprofol works in older adults who are having limb surgery under general anesthesia at Shanghai Geriatric Medical Center.
- Conditions
- Hip Fractures (ICD-10 72.01-72.2), Osteoarthritis, Knee and Hip, Femoral Neck Fractures
- Trial name
- NCT07301242
- Testing
- Ciprofol
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Geriatric Medical Center
Tibial Fractures, Femoral Fractures
Distal Locking Using an Electromagnetic Field Guided Computer Based Real Time System for Orthopaedic Trauma Patients
Hypothesis: Utilization of the "wand" method will enhance improvements in drill placement, locking nail placement during tibia and femur fracture repairs, and offer less radiation exposure and less operative time.
- Trial name
- Sure Shot (NCT01183078)
- Testing
- free-hand, Wand technique
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Wake Forest University Health Sciences
Hip Fracture
Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia
Purpose: This study aims to compare the emergence time among three anesthesia regimens: remimazolam, remimazolam with flumazenil, and propofol in elderly patients undergoing hip replacement surgery.
- Trial name
- NCT06513923
- Testing
- Remimazolam, Flumazenil, Propofol
- Where
- 2 sites in China
- Volunteers
- 136 people
- Sponsor
- Central South University
Orthopaedic Trauma Infections
BBOT: Bacterial Burden in Ortho Trauma Procedures
The purpose of this research project is to improve understanding of the potential role of highly sensitive bacterial tests in diagnosing infected non-healing fractures compared to the current standard of care, microbiologic…
- Trial name
- NCT03126448
- Testing
- Highly Sensitive Assays
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Surgical Scar
The Management of Surgical Scars Around Knee After Pediatric Orthopedic Surgery: an Observational, Case-control Study
Scar is an unpleasant symptom that commonly appear after orthopedic surgery, especially the joint procedure. Due to the wide motion range, skin around joint has excessive tension that may increase risk for wide or conspicuous…
- Trial name
- NCT04928443
- Testing
- Scar dressing group, Regular care group
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Orthopedic Trauma Wounds
Open Label Trial of NanoDOX Hydrogel in Orthopedic Trauma Wounds With and Without Vacuum Assisted Closure Therapy
The purpose of this study is to determine the effect of NanoDOX™ Hydrogel in conjunction with serial wound debridement and irrigation on the healing rates of open traumatic orthopedic and soft tissue wounds when compared to a…
- Trial name
- NCT01518491
- Testing
- NanoDOX Hydrogel, VAC Alone
- Where
- 2 sites in United States
- Sponsor
- NanoSHIFT LLC
Hip Fractures, Knee Arthroplasty
Continuous Spinal Anesthesia Versus Combined Spinal Epidural Block
In major orthopaedic surgery of the lower extremities both continuous spinal anesthesia (CSA) and combined spinal epidural anesthesia (CSE) are safe and reliable anaesthesia methods.
- Conditions
- Hip Fractures, Knee Arthroplasty, Femur Fracture
- Trial name
- Spinocath (NCT00616044)
- Testing
- continuous spinal anesthesia, Spinocath a catheter for continuous spinal anesthesia, combined spinal epidural anesthesia
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Tibia Fracture
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
The proposed study is a two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial. 1,000 patients with tibia fractures treated with intramedullary (IM) nail will be randomized into two treatment arms.
- Trial name
- NCT05000281
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Pelvic, Acetabular, Femur, or Diaphyseal Tibial Operative Orthopaedic Injuries
Patient-Specific Precision Injury Signatures in Multiply Injured Orthopaedic Patients
The purpose of this study is to evaluate the use of precision methods that quantify injury and response to injury to predict how short-term clinical outcomes are affected by initial and staged orthopaedic interventions in…
- Trial name
- PRECISE (NCT03772730)
- Where
- 8 sites in United States
- Volunteers
- 320 people
- Sponsor
- Major Extremity Trauma Research Consortium
Ischemia, Blood Circulation Disorder
Early Discovery of Ischemia After Replantation Surgery of the Extremities
Investigators will test if changes in CO2 is detected postoperatively in ischemic tissue in a replanted extremity of a traumatically amputated upper or lower extremity.
- Conditions
- Ischemia, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- EDIR (NCT05297266)
- Testing
- IscAlert
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Hemorrhagic Shock, Pelvic Fractures
Hemorrhagic Shock in Orthopedic Fractures
The goal of this observational study is to learn about the incidence and predators of hemorrhagic shock in patients with Long bone and pelvic fractures .The main question it aims to answer is: In which bone fracture the…
- Conditions
- Hemorrhagic Shock, Pelvic Fractures, Long Bone Fractures
- Trial name
- NCT07695129
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Sohag University
Ligament Knee Injury, Anterior Cruciate Ligament Rupture
Optimized Rehabilitation After Anterior Cruciate Ligament Before Returning to Sport
Following reconstruction of the anterior cruciate ligament (ACL), a standardized rehabilitation protocol is carried out by a physiotherapist.
- Trial name
- ORACL-Run (NCT05323474)
- Testing
- Usual rehabilitation, Rehabilitation optimized
- Where
- 8 sites in France, Switzerland
- Volunteers
- 432 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pain, Postoperative, Change; Circulatory
The Influence of Peripheral Nerve Blocks in Patients Undergoing Limb Orthopedic Surgery
To investigate pre-op peripheral nerve block in reducing peri-op IL-6 level and post-op pain
- Conditions
- Pain, Postoperative, Change; Circulatory, Surgical Injury
- Trial name
- NCT03913650
- Testing
- 0.25% bupivacaine
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital