Clinical trials: Orthopedic Surgeries
Geriatric Patients, Postoperative Complications
PREDICTING MINS WITH FRAILTY AND BIOMARKERS IN GERIATRIC SURGERY
The primary objective of this study is to develop and validate a machine learning model that integrates preoperative clinical data, biomarkers, and modified frailty indices (mFI-5) to accurately predict myocardial injury after…
- Conditions
- Geriatric Patients, Postoperative Complications, Frailty, Myocardial Ischemia
- Trial name
- NCT07566013
- Testing
- Preoperative Risk Assessment and Machine Learning Modeling
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- DİLEK KALAYCI
Iron Deficiency Anemia
Short-term Intravenous Iron Isomaltose Anhydride for IDA
This prospective, randomized, controlled study aims to evaluate the impact of short-term intravenous iron isomaltose anhydride on postoperative recovery and the requirement for allogeneic red blood cells (RBC) transfusion in…
- Trial name
- NCT03915327
- Testing
- Intravenous iron isomaltose anhydride
- Volunteers
- 1,600 people
- Sponsor
- West China Hospital
Orthopedic/Podiatry Procedures
Effects of Dexmedetomidine on Tourniquet Pain Associated With Lower Extremity Surgeries Under General Anesthesia
This study is being done to determine if the drug known as dexmedetomidine improves the way we care for patients when their surgery involves the use of a tourniquet on the leg.
- Trial name
- NCT00932386
- Testing
- Dexmedetomidine Hcl infusion, normal saline
- Where
- United States
- Sponsor
- Rutgers, The State University of New Jersey
Rotator Cuff Tear
Surgical Safety and Effectiveness in Orthopedics: Swiss-wide Multicenter Evaluation and Prediction of Core Outcomes in Arthroscopic Rotator Cuff Reconstruction
Surgical safety and effectiveness in orthopedics: Swiss-wide multicenter evaluation and prediction of core outcomes in arthroscopic rotator cuff reconstruction.
- Trial name
- ARCR_Pred (NCT04321005)
- Testing
- arthroscopic rotator cuff reconstruction
- Where
- 20 sites in Germany, Switzerland
- Volunteers
- 973 people
- Sponsor
- University Hospital, Basel, Switzerland
Thromboses, Deep Vein, Surgery--Complications
Thromboprophylaxis in Patients Undergoing Orthopedic Surgeries; Comparison Between Rivaroxaban and Enoxaparin
The main objective is to reduce the incidence of venous thromboembolism (VTE) in orthopedic postoperative patients based on the potential benefit of using rivaroxaban as a monotherapy.
- Trial name
- NCT03299296
- Testing
- Rivaroxaban 10 Milligrams, Enoxaparin 40 Milligrams/0.4 Milliliters Prefilled Syringe
- Volunteers
- 100 people
- Sponsor
- Ahmed AbdelMoneim Hassan Ali
Postoperative Complications, Orthopedic Disorder
PaO2 and Lung Function After Orthopedic Surgery
Hypoxia and reduced oxygen partial pressure is commonly occurring after abdominal surgery. This study aims to investigate whether similar changes also occur after orthopedic surgery in the form of upper limb surgery.
- Trial name
- NCT05227573
- Testing
- Orthopedic surgery
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Postoperative Pain
Pre- Versus Post-incisional Pregabalin for Postoperative Pain Attenuation and Analgesics Spare in Orthopedic Oncologic Patients
Hypothesis No studies considered the comparison of preemptive vs. post-surgery Pregabalin (PGL) only administration. The investigators believe that the administration of PGL preemptively would diminish pain sensation and…
- Trial name
- NCT01359059
- Testing
- Pregabalin
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Arthritis, Osteoarthritis, Knee
Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement
The study will describe the short-term effects the study drug, rivaroxaban, has on the body when a patient is switched from enoxaparin injection (by needle) to oral rivaroxaban (by mouth) for the prevention of blood clotting in…
- Conditions
- Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
- Trial name
- NCT01094886
- Testing
- Rivaroxaban
- Where
- 5 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Postoperative Pain
A Comparison of Bupivacaine and Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting
The efficacy of three postoperative pain management regimens will be compared in patients undergoing Lefort I osteotomy or alveolar cleft repair with Iliac crest bone grafts (ICBG) to determine the best way of managing…
- Trial name
- NCT00405262
- Testing
- Ketorolac, Bupivacaine, ketorolac + bupivacaine
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- The Hospital for Sick Children
Orthopedic Surgery
New Methods to Detect a Decrease in Heart Function
The purpose of this study was to evaluate the changes in heart function during onset of spinal anesthesia using a new and less invasive method, the LidcoTMplus.
- Trial name
- NCT00192894
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Postoperative, Osteoarthritis
Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine
The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.
- Trial name
- NCT00270322
- Testing
- Marcaine 0.166% + Fentanyl 3.33 mcg/ml, Morphine sulphate
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Radiography, Orthopedic Surgery
Brain Power Spectral Density Under Propofol
In the operating room, the state of anesthesia is monitored during general anesthesia-induced hypnosis through EEG-based neuro-monitoring.
- Conditions
- Radiography, Orthopedic Surgery, Interventional
- Trial name
- PROBRAIN (NCT03876379)
- Volunteers
- 60 people
- Sponsor
- Joaquim MATEO
Incision, Surgical
Orthopaedic Surgical Wound Closure Comparison Study
This study is trying to find out if there is one method of surgical incision closure is better than another. The three different wound closure methods in this study are currently used in standard of care.
- Trial name
- NCT05251064
- Testing
- Suture, Clozex, Zipline
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Virginia
The Effect of Preoperative Administration of Oral Tizanidine, Post Operative Pain
The Effect of Preoperative Administration of Oral Tizanidine on the Postoperative Pain and Sleep Quality
The majority of lower limb fractures treated with surgery often leading to significant morbidity and mortality. Despite improvements in perioperative care, about 20% suffer from severe postoperative complications.
- Trial name
- Tizanidine (NCT07800364)
- Testing
- Tizanidine
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Tanta University
Anesthesia
Effect of Acupoint Electrical Stimulation on Incidence of Hypotension After Spinal Anesthesia
This study is intended to include elderly patients who are selected to undergo lower limb and pelvic orthopedic surgery under spinal anesthesia.
- Trial name
- NCT05716399
- Testing
- Transcutaneous electric stimulation pretreatment, Transcutaneous acupoint electrical stimulation treatment, Transcutaneous acupoint pseudo electric stimulation
- Volunteers
- 111 people
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Arthroscopic Knee Surgery
A Pilot Study to Determine the Efficacy of Intravenous Ibuprofen for Pain Control Following Arthroscopic Knee Surgery
The intent of this study is to assess the analgesic efficacy of IV ibuprofen when administered at induction of anesthesia. Results from this pilot study will be used to design and determine the appropriate statistical power for a…
- Trial name
- NCT01650519
- Testing
- IV ibuprofen, IV ketorolac
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Cumberland Pharmaceuticals
Orthopedic Surgery, Pain, Postoperative
The Effect of Music Therapy on Pain Level and Analgesic Consumption
Pain is a common condition experienced by patients in long-term health care, rehabilitation and acute situations, due to various surgical interventions and invasive procedures, and postoperative pain is an important symptom…
- Conditions
- Orthopedic Surgery, Pain, Postoperative, Analgesia
- Trial name
- NCT05424211
- Testing
- Music Therapy Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cukurova University
Anesthesia, Cognitive Dysfunction
Evaluation of Cognitive Functions by Cerebral Pulse Oximetry
General and Spinal Anesthesia can be used in geriatric patients in orthopedic surgery. Post-op cognitive dysfunction can be seen in orthopedic surgeries in this group of patients.
- Trial name
- NCT03827083
- Testing
- cerebral pulse oximetry
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Regional Anesthesia Morbidity, Postoperative Pain
Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques
We will enroll patients submitted to feet elective orthopaedic surgery that require analgesia through continuous peripheral nerve block (CNPB) of the sciatic nerve.
- Trial name
- NCT02029404
- Testing
- Tibial nerve group, Tibial peroneal nerve group
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Total Joint Revisions
Retrieval and Analysis of Orthopedic Implants at Revision Arthroplasty Surgery
The goal of this is to improve durability of total joint replacements in patients, thereby improving clinical outcomes and implant performance.
- Trial name
- NCT01425021
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Utah