Clinical trials: Orthopedic Surgeries
Regional Anaesthesia
Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery
this study is designed to evaluate and compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to 0.5% bupivacaine in ultrasound-guided infraclavicular brachial plexus block for patients undergoing elective upper limb…
- Trial name
- NCT07279727
- Testing
- Nalbuphine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Intraoperative Hypotension, Acute Kidney Injury
Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension
In order to reduce the incidence of IOH, various goal-directed therapy (GDT) protocols have already been introduced with success regarding the reduction of postoperative AKI and MINS.
- Conditions
- Intraoperative Hypotension, Acute Kidney Injury, Myocardial Injury After Non-cardiac Surgery
- Trial name
- Clearsight (NCT06291714)
- Testing
- GDT-based hemodynamic management based on Clearsight device
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Giessen
Distal Radius Fractures, Wrist Fractures
Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery
Orthopedic wrist procedures often cause significant postoperative pain. A supraclavicular nerve block is an effective and proven method to help reduce postoperative pain and decrease opioid use around the time of upper extremity…
- Trial name
- Vs (NCT06179004)
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Epidural; Anesthesia, Catheter Complications
Nylon Versus Polyurethane Epidural Catheters In Patients Undergoing Major Orthopedic Surgery
Objectives: To compare the safety and efficacy of nylon (polyamide) epidural catheter versus polyurethane epidural catheter in patients undergoing major orthopedic surgery under continuous epidural anesthesia.
- Conditions
- Epidural; Anesthesia, Catheter Complications, Catheter Blockage, Catheter Dysfunction
- Trial name
- NCT05168943
- Testing
- Nylon (Polyamide) Epidural Catheter, Polyurethane Epidural Catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Orthopaedic Surgery (30 Minutes or Longer)
The Effect of Plasma-air-filtration on the Incidence of Surgical Site Infections in Orthopaedic Surgery
The study is a multicenter, double-blind, randomized, controlled trial conducted at six major university and teaching hospitals with a catchment population of approximately 2 million.
- Trial name
- EPOS (NCT02695368)
- Testing
- Novaerus NV800 on, Novaerus NV800 off, Novaerus NV800 on or off
- Where
- Sweden
- Volunteers
- 45,000 people
- Sponsor
- Karolinska Institutet
Surgical Site Infection
Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients
Intervention: This study will involve three different study arms with different interventions prior to surgery: (1) shower only, (2) shower plus Theraworx wipes, (3) shower plus chlorhexidine wipes Study Design: Single center RCT…
- Trial name
- NCT03401749
- Testing
- Chlorhexidine Gluconate 2% Wipe, Theraworx Bath Wipes
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- University of Alabama at Birmingham
Cerebral Palsy, Hemiplegia
Functional Benefits of Multisite Upper Limb Surgery in Children With Unilateral Cerebral Palsy (RETRO-CHIRc)
This retrospective study evaluates the functional impact of individualized multisite neuro-orthopedic upper limb surgery in children with unilateral cerebral palsy (hemiplegic CP).
- Trial name
- RETRO-CHIRc (NCT07891078)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française
Total Hip Arthroplasty (THA), Kinesiophobia
Preoperative Video-Based Education in Total Hip Arthroplasty
This single-center, prospective, randomized controlled trial aims to evaluate the effect of preoperative video-based mobilization education on postoperative fear of movement (kinesiophobia), pain during first mobilization, and…
- Conditions
- Total Hip Arthroplasty (THA), Kinesiophobia, Postoperative Pain, Early Mobilization
- Trial name
- NCT07279974
- Testing
- Video-Based Mobilization Education, Standard Verbal Education
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Acibadem University
Congenital Skelectal Anomaly
A Comparative Study of the Effect of Epidural Dexmedetomidine Versus Fentanyl Added to Ropivacaine in Pediatric Orthopedic Surgery
The purpose of this study is to evaluate the effect of epidural dexmedetomidine added to ropivacaine in pediatric orthopedic surgery
- Trial name
- NCT02375191
- Testing
- fentanyl, dexmedetomidine, Ropivacaine
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Yonsei University
Metastatic Cancer to the Hip
Fully Constrained Acetabular Liner vs. Dual Mobility Hip Joint in the Surgical Treatment of Metastatic Bone Disease of the Hip
The purpose of the current study is to investigate whether dual mobility liners are non-inferior til constrained liners regarding the post-operative hip joint dislocation risk following total hip replacement in patients with…
- Trial name
- NCT05461313
- Testing
- Constrained Liner, Dual Mobility
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anesthesia, Dexmedetomidine
IV Dexmedetomidine in the Duration of Spinal Anesthesia With Hyperbaric Bupivacaine: Double Blind Randomized Trial.
Introduction: Spinal anesthesia produces sensitive and motor block according to the administered local anesthetic. The total duration of surgical anesthesia depends on the dose, intrinsic properties of the anesthetic, and the use…
- Trial name
- NCT05335655
- Testing
- Dexmedetomidine injection, Sodium Chloride 0.9% infusion
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
Lower Limb Orthopedic Surgery
Intravenous Dexmedetomidine Versus Midazolam in Preventing Shivering in Trauma Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia
Shivering is a common and significant complication following spinal anesthesia, with a reported incidence of 40-60% especially in trauma patients due to pain, stress response, blood loss, and disrupted thermoregulation.
- Trial name
- NCT07300826
- Testing
- Dexmedetomidine, Midazolam
- Volunteers
- 100 people
- Sponsor
- Assiut University
Neurosurgery, Orthopedic Surgery
Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery
Spinal surgery may be associated with substantial blood loss which often requires erythrocyte transfusion. Transfusion of red blood cells (RBC) is not free of adverse events and has been associated with increased risks of…
- Conditions
- Neurosurgery, Orthopedic Surgery, Red Blood Cell Transfusion
- Trial name
- NCT01258010
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Orthopaedic Surgery
Pharmacokinetic, Pharmacodynamic and Pharmacogenetic of Morphine After Surgery
The main objective of this study is to improve our knowledge on the pharmacodynamic, pharmacokinetic, and pharmacogenetic relationships of morphine administered to relief severe postoperative pain.
- Trial name
- NCT00822549
- Testing
- intravenous morphine titration
- Where
- France
- Volunteers
- 438 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preoperative Olfactory Training, Postoperative Delirium
Effect of Preoperative Olfactory Training on Postoperative Delirium in the Elderly Undergoing Orthopedic Surgeries
To observe whether preoperative olfactory training can reduces the incidence of postoperative delirium in elderly patients undergoing orthopedic surgeries, a prospective randomized controlled study method will be used in this…
- Trial name
- NCT05908318
- Testing
- olfactory training
- Volunteers
- 450 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Post Operative Cognitive Dysfunction
Ketamine and Postoperative Cognitive Dysfunction
Over 30 million patients require a major surgery annually in the US alone and more than half of them are performed in patients over 60 years of age.
- Trial name
- POCK (NCT02892916)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 307 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Vein Thrombosis
A Safety and Efficacy Study of BCD-080 Compared to Clexan for Deep Vein Thrombosis Prophylaxis at Orthopedic Surgeries
The purpose of the study is to prove equivalence of efficacy and safety of BCD-080 and Clexan for deep vein thrombosis and embolism prophylaxis at orthopedic surgeries.
- Trial name
- NCT02368314
- Testing
- Sodium Enoxaparine
- Where
- Russia
- Volunteers
- 124 people
- Sponsor
- Biocad
Ambulatory Patients in the Dep. of Medical Gastroenterology, Ambulatory Patients in the Dep. of Gynecology
Outpatients' Knowledge About and Attitude Toward Randomised Clinical Trials
The purpose of this study is to investigate the knowledge about randomised clinical trials and the attitude towards clinical research among Danish outpatients.
- Conditions
- Ambulatory Patients in the Dep. of Medical Gastroenterology, Ambulatory Patients in the Dep. of Gynecology, Ambulatory Patients in the Dep. of Orthopedic Surgery, Ambulatory Patients in the Dep. of Urology
- Trial name
- INFO-I (NCT03094598)
- Testing
- Leaflet, Brochure, Booklet
- Where
- 2 sites in Denmark
- Volunteers
- 428 people
- Sponsor
- Copenhagen Trial Unit, Center for Clinical Intervention Research
Pressure Sore, Orthopedic Disorder
Body Temperature Changes and Early Postoperatıve Pressure Sore
This study aims to determine effect of body temperature changes during total knee arthroplasty surgery on early postoperative pressure sore formation.
- Conditions
- Pressure Sore, Orthopedic Disorder, Hypothermia, Nursing Caries
- Trial name
- NCT05552599
- Testing
- woolen blanket
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Hitit University
Hip Fractures, Knee Fracture
Evaluation of Multidisciplinary Recovery After Surgery Program in Orthopedics and Traumatology
The aim of the recovery protocol is to reduce surgical trauma, postoperative pain, and complications, shorten hospital treatment and improve postoperative recovery.
- Conditions
- Hip Fractures, Knee Fracture, Hip Arthritis, Knee Arthritis
- Trial name
- NCT03822247
- Testing
- Multidisciplinary Recovery Program
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- Klinički Bolnički Centar Zagreb