Clinical trials: Orthopedic Surgeries
Wound Healing Time, Total Hip Arthroplasty (THA)
Wound Healing, Dressing Type, and Dressing Change Frequency in THA
Surgical wound complications following primary total hip arthroplasty remain a significant clinical challenge despite advances in wound care technologies.
- Trial name
- CAP-HIP (NCT07655388)
- Testing
- VACUTEX™ wound dressing, Octenisept® wound care dressing
- Where
- Serbia
- Volunteers
- 90 people
- Sponsor
- Clinical Center of Vojvodina
Arthropathy of Knee, Arthropathy of Hip
Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery
The purpose of this research study is to evaluate effects of respiratory strengthening exercises on breathing function, in people who have orthopedic surgery.
- Conditions
- Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
- Trial name
- NCT05381818
- Testing
- Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Florida
Osteoarthritis, Arthritis
Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up
In this study the investigators will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction…
- Conditions
- Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02717559
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
Pain Relief After Forefoot Surgery
Ultrasound Guided Ankle Block Versus Medial Forefoot Block for Forefoot Surgery
Forefoot surgery includes bunion surgery and similar reconstructive bone cutting surgery and is very painful. Local anaesthetic nerve blocks have been used for many years to help alleviate pain following this surgery.
- Trial name
- USGAB (NCT01386320)
- Testing
- Ultrasound guided ankle block, Medial forefoot block
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Pain, Postoperative
Efficacy and Safety of Intranasal Morphine for Pain After Elective Orthopedic Surgery
Multiple-center, multiple-dose, randomized, double-blind, six-arm, active- and placebo-controlled study in patients with moderate to severe post-surgical pain from elective orthopedic surgery with safety observed for a total of…
- Trial name
- NCT00390039
- Testing
- Intranasal Morphine, IV morphine
- Where
- 7 sites in United States
- Volunteers
- 256 people
- Sponsor
- Javelin Pharmaceuticals
Anesthesia, Local, Anesthesia
Regional Anesthesia in Pediatric Orthopaedic Patients
To identify the benefits from regional anesthesia use as pain management in the pediatric population by delineating the differences in efficacy of continuous nerve blockade versus single-shot techniques after pediatric…
- Conditions
- Anesthesia, Local, Anesthesia, Orthopedic Disorder
- Trial name
- NCT04669145
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ochsner Health System
Complex Regional Pain Syndromes, Distal Radius Fractures
Prednisone for CRPS in Distal Radius Fracture
Wrist fractures are the most prevalent adult fracture. Complex regional pain syndrome (CRPS) is a common complication that can occur, leading to permanent disability and is costly to the patient and healthcare system.
- Trial name
- NCT06453447
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Postoperative Delirium, Stroke
Cyclopofol Versus Propofol for Postoperative Delirium in Elderly Patients Having Orthopedic Surgery
Postoperative delirium (POD) is common in elderly patients recovering from surgery and anesthesia. POD has adverse effects on early and long-term prognosis.
- Trial name
- NCT06046638
- Testing
- Cyclopofol, Propofol
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Orthopedic Disorder, Arthropathy of Knee
Study to Reduce Sitting in Older Adults Undergoing Hip or Knee Replacements
The aim of this study is to investigate the feasibility of an intervention to reduce sedentary behaviour in older adults waiting for hip and knee replacements.
- Conditions
- Orthopedic Disorder, Arthropathy of Knee, Arthropathy of Hip, Sedentary Lifestyle
- Trial name
- INTEREST (NCT03740412)
- Testing
- Sedentary behaviour reduction using motivational interviewing, education, individualised feedback, goal-setting, self-monitoring, environmental modification, and supportive phone calls
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Birmingham
Orthopedic Disorder, Total Knee Replacement
Combined Adductor&Sciatic Nerve Block vs Femoral&Sciatic Nerve Block in Total Knee Replacement Surgery
Knee joints, one of the largest and most functional joints of the human body, have great features to provide ideal body posture and movement.
- Conditions
- Orthopedic Disorder, Total Knee Replacement, Post Operative Pain, Surgery
- Trial name
- NCT05648708
- Testing
- Combine Adductor Canal & Sciatic Nerve Block, Combine Femoral & Sciatic Nerve Block, Bupivacaine and prilocaine hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Anesthesia; Functional
Ultrasound-assisted Spinal Anesthesia in Midline Versus Paramedian Approach in Adult Orthopedic Surgery
This study aims to compare between the two methods (midline and paramedian approach of spinal anesthesia guided by ultrasound) by the number of needle passes required to successful dural puncture.
- Trial name
- NCT07047469
- Testing
- Group (1): spinal anesthesia with median approach, Group (2): spinal anesthesia with paramedian approach
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Sohag University
Soft Tissue Sarcoma Adult
Study of a Cohort of Cases of Synovial Sarcoma Treated in the Orthopedic Surgery and Traumatology Department of the Hospital de Sant Pau Between 1983 and 2016
The main objectives of this study are the following: to describe the prognostic factors of survival of synovial sarcoma in patients treated by the orthopedic surgery unit oncologic of the orthopedic surgery and traumatology…
- Trial name
- NCT03833037
- Testing
- Soft tissue sarcomas in adults
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cognitive Impairment, Mild
Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With MCI
According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups.
- Trial name
- MCI (NCT03165396)
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Third Central Clinical College of Tianjin Medical University
Femoral Fractures, Pelvic Fractures
Tactile Incentiviser Improves Partial Weight Bearing After Lower-Limb Surgery
Background: After lower-limb surgery, many patients are instructed to walk with only a fraction of their body weight on the operated leg (partial weight bearing).
- Conditions
- Femoral Fractures, Pelvic Fractures, Hip Fractures (ICD-10 72.01-72.2), Hip Arthroplasty
- Trial name
- NCT06989554
- Testing
- mechanical feedback insole, Standard physiotherapy without feedback device
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Università degli Studi dell'Insubria
Shoulder Osteoarthritis, Rotator Cuff Injuries
CBD for Pain Following Orthopedic Shoulder Surgery
The goal of the study is to learn if Epidiolex (cannabidiol) works as a additional pain medication in patients who have had orthopedic shoulder surgery.
- Trial name
- CBD (NCT06381791)
- Testing
- Epidiolex
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Methodist Hospital Research Institute
Fractures, Bone, Dislocations
Prospective Abuse and Intimate Partner Violence Surgical Evaluation
Intimate partner violence (IPV), also known as domestic abuse, is a leading cause of non-fatal injury in women worldwide. 1 in 6 women attending surgical fracture clinics have a history of IPV in the past year.
- Conditions
- Fractures, Bone, Dislocations, Spouse Abuse
- Trial name
- PRAISE-2 (NCT02529267)
- Testing
- Standard of care
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Environment, Waste Output
USE LESS, a Comparative Cohort Study of Climate Change Impact From Orthopedic Surgery
A prospective comparative cohort study with the objective to quantify and compare carbon dioxide equivalent (CO₂e) emissions from orthopedic surgeries performed in two different operating room (OR) settings using different sets…
- Trial name
- USELESS (NCT07657039)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Red Blood Cells Transfusion.
Restrictive Versus Liberal Red Cell Transfusion Strategy in Orthopedic-Oncology Patients Undergoing Surgery - a Randomized Controlled Study
The rationale for perioperative red blood cell (RBC) transfusion is based on the observation that anemia is an independent risk factor for morbidity and mortality after cardiac operations.
- Trial name
- NCT01491308
- Testing
- Red blood cells transfusion
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Surgical Site Infection
Investigation of Environmental Parameters in Operating Rooms
Postoperative surgical site infection (SSI) is a serious and complicated healthcare-associated infection (HAI) affecting about 2% of patients undergoing orthopedic surgery.
- Trial name
- NCT05816135
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Sahlgrenska University Hospital
Medication Disposal, Behavior
Excess Opioid Disposal Following Orthopedic Foot and Ankle Surgery
This study aims to survey the drug disposal methods of orthopedic foot and ankle patients with excess pain medication following and operation.
- Trial name
- NCT03285061
- Testing
- Deterra Drug Deactivation System
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital