Clinical trials: Orthopedic Surgery of Lower Limb
Bone Metastases, Lower Extremity Fracture
External Beam Radiation Therapy Post Surgery in Patients With Lower Extremity Bone Metastases Randomized Efficacy Trial
The objective of the present study is to evaluate the effectiveness of post-operative radiation therapy in lower extremity bone metastases.
- Conditions
- Bone Metastases, Lower Extremity Fracture, Pathological Fracture, Impending Fracture
- Trial name
- EXPLORE (NCT04109937)
- Testing
- External beam radiation therapy
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
Hemostasis
HEMOBLAST Pilot Clinical Investigation
The primary objective of this pilot clinical investigation is to assess the reliability of the Surface Bleeding Severity Scale (SBSS) in a clinical setting.
- Trial name
- NCT02502019
- Testing
- HEMOBLAST Bellows
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Biom'Up France SAS
Medial Malleolus Fracture, Lisfranc Injury
Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF Investigation
The study in question is a post market clinical follow up (PMCF) study to evaluate the safety and performance of bioabsorbable headless compression screw Inion CompressOn in selected fracture, osteotomy and arthrodeses operations…
- Conditions
- Medial Malleolus Fracture, Lisfranc Injury, Lisfranc Fracture, Talus Fracture
- Trial name
- NCT05555459
- Testing
- Operation
- Where
- Finland
- Volunteers
- 125 people
- Sponsor
- Inion Oy
Hip Fractures (ICD-10 72.01-72.2)
Risk Early Warning Management for Postoperative Hip Fracture Rehabilitation and Delirium Prevention in Elderly Patients
This clinical study aims to evaluate the effectiveness of a perioperative risk early warning management strategy in patients undergoing surgical treatment for hip fractures.
- Trial name
- NCT06966947
- Testing
- Risk Early Warning Management, Standard Perioperative Care
- Where
- China
- Volunteers
- 284 people
- Sponsor
- People's Hospital Affiliated to Hubei University of Medicine
Postoperative Pain
Comparison of Pain Relief Duration With Dexmedetomidine Versus Fentanyl Added to Spinal Anesthesia in Patients Undergoing Lower Limb Orthopedic Surgery
The goal of this randomized clinical trial is to compare how long effective pain relief lasts when dexmedetomidine or fentanyl is added to hyperbaric bupivacaine during spinal anesthesia for lower limb orthopedic surgery.
- Trial name
- NCT07770542
- Testing
- Dexmedetomidine & Bupivacaine., fentanyl and bupivacaine
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Allama Iqbal Teaching Hospital
Post Spinal Anesthesia Shivering
The Effect of Different Doses of Dexamethasone on Post Spinal Anesthesia Shivering
The precise etiology of post-spinal anesthesia shivering (PSAS) is not fully understood. The incidence ranges between 20 to 80%.
- Trial name
- NCT06999070
- Testing
- Dexamethasone 0.1mg/kg, Dexamethasone 0.3mg/kg
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain, Hip Osteoarthritis
Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blocks for Hip Surgery Analgesia
This study aims to investigate the efficacy of adding a Posterior Pericapsular Deep gluteal block to two other standard nerve blocks-the Pericapsular Nerve Group block and the Lateral Femoral Cutaneous Nerve block-for patients…
- Conditions
- Postoperative Pain, Hip Osteoarthritis, Hip Fractures
- Trial name
- NCT07531030
- Testing
- Posterior Pericapsular Deep Gluteal, Pericapsular Nerve Group, and Lateral Femoral Cutaneous Nerve Blocks., Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blocks.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Fracture of Neck of Femur
Orthopedic Intelligent Navigation System in the Treatment of Fresh Femoral Neck Fractures
The goal of this clinical trial is to verify the safety and effectiveness of orthopaedic surgical navigation system in the treatment of fresh femoral neck fractures.
- Trial name
- NCT06713018
- Testing
- Three cannulated compression screws by navigation system, Traditional three cannulated compression screws
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Surgery
Femoral Preincisional Block in Acute Postoperative Pain Management of Surgery Orthopaedic Lower Limb
Proper management of acute postoperative pain (DAPO) is essential for the recovery of orthopedic surgeries. The blockade of the femoral nerve preincisional (BFP) is simple and its effectiveness increases guided by ultrasound and…
- Trial name
- NCT02239497
- Testing
- Femoral block by ultrasound and neurostimulation, Intravenous analgesia
- Where
- Venezuela
- Volunteers
- 30 people
- Sponsor
- Hospital Central Dr. Luis Ortega
Surgical Site Infection
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF)…
- Trial name
- POTENT (NCT05763602)
- Testing
- povidone-iodine topical ointment
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Loreen Herwaldt
Neck of Femur Fracture, Fractures, Bone
A Quality Improvement Project to Assess and Refine the Handover Process at Morning Trauma Meetings
This project was intended to observe the handover of trauma and orthopaedic patients at a district general hospital in the UK. Following the implementation of a standard operating protocol, the handover of patient information…
- Conditions
- Neck of Femur Fracture, Fractures, Bone, Orthopedic Disorder
- Trial name
- NCT04514601
- Testing
- Standard Operating Protocol
- Where
- United Kingdom
- Volunteers
- 317 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Orthopedic Surgery-lower Leg Surgery
Efficacy of Peripheral Nerve Stimulator in Assessing Sensory Nerve Block Level of Spinal Anesthesia
Various methods are used to assess the level of anesthesia block after spinal anesthesia. Among them, ice cubes, alcohol swabs, and needles are commonly used in the clinical setting, but ice is limited by difficulties with…
- Trial name
- NCT01768780
- Testing
- the anticholinergic glycopyrrolate 0.1 ㎎ + 0-15 mg hyperbaric bupivacaine
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Shivering
Comparative Study Between the Prophylactic Intravenous Administrations of Acetaminophen vs Dexamethasone vs Pethidine Regarding the Incidence of Shivering Induced by Single Shot Spinal Anesthesia in the Orthopedic Surgeries of the Lower Limbs
Single Shot Spinal anesthesia (SSSA) is associated with considerable perioperative shivering and can be challenging to treat. Some pharmacologic agents like N-methyl d-aspartate receptor antagonists, magnesium sulfate and opioid…
- Trial name
- NCT05284409
- Testing
- Pethidine, Acetaminophen, Dexamethasone
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Orthopedic Disorder, Post Operative Pain
TENS for Relief of Postoperative Pain in Orthopedic Patients
To ensure early mobilization, minimize suffering, and to prevent postoperative complications postoperative pain should be reduced as soon and as effectively as possible.
- Conditions
- Orthopedic Disorder, Post Operative Pain, Hip Fractures, Arthroplasty, Replacement, Hip
- Trial name
- NCT05678101
- Testing
- transcutaneous electrical nerve stimulation (TENS)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Ligament Knee Injury, Anterior Cruciate Ligament Rupture
Optimized Rehabilitation After Anterior Cruciate Ligament Before Returning to Sport
Following reconstruction of the anterior cruciate ligament (ACL), a standardized rehabilitation protocol is carried out by a physiotherapist.
- Trial name
- ORACL-Run (NCT05323474)
- Testing
- Usual rehabilitation, Rehabilitation optimized
- Where
- 8 sites in France, Switzerland
- Volunteers
- 432 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pain, Postoperative
Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia
The purpose of this study is to determine whether, for surgery of the tibia, one dose of methadone provides better control of pain afterward as compared to morphine, which is the usual drug given to control pain after surgery.
- Trial name
- NCT01430182
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Flat Foot, Pressure Ulcer
Polyurethane Foam on the Heel for Prevention in Children
The post-operative treatment of pediatric patients operated for the correction of flat foot, sees today the use of preformed leg-foot splint (Walker) as an alternative to the application of plaster casts.
- Trial name
- SCHIUMABIMB (NCT03039179)
- Testing
- polyurethane foam dress
- Volunteers
- 80 people
- Sponsor
- Istituto Ortopedico Rizzoli
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
Onset Time of Nerve Block: A Comparison of Two Injection Locations in Patients Having Lower Leg/ Foot Surgery
The purpose of this study is to compare injecting local anesthetic (numbing medication) in different patterns around a major nerve in the leg.
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/or Foot
- Trial name
- NCT01542840
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Lower Limb Fracture
Prognostic Value of Preoperative Frailty Assessment in Geriatric Lower Limb Orthopedic Surgery
This retrospective study evaluates the effectiveness of frailty assessment tools-specifically the Risk Analysis Index (RAI) and the 5-Item Modified Frailty Index (5-mFI)-in predicting postoperative outcomes for elderly patients…
- Trial name
- NCT07422025
- Testing
- Preoperative Frailty Scoring
- Where
- Egypt
- Volunteers
- 149 people
- Sponsor
- Benha University
Geriatric Population, Spinal Anesthesia Induced Hypotension
HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS
The goal of this clinical trial is to find out whether height-based dosing of spinal anaesthesia provides better hemodynamic stability and anesthetic outcome than conventional fixed dosing in elderly patients undergoing lower…
- Conditions
- Geriatric Population, Spinal Anesthesia Induced Hypotension, Spinal Anesthesia in Elderly Patients
- Trial name
- NCT07363941
- Testing
- Group A : Spinal Anaesthetic Dose, Group B : Conventional Dose
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma