Clinical trials: Orthopedics
Pediatric Distal Forearm Fractures
Closed Reduction of Distal Forearm Fractures by Pediatric Emergency Medicine Physicians: A Prospective Study
Distal forearm fractures are amongst the most frequently encountered orthopedic injuries in the pediatric emergency department (ED). Immediate closed manipulation and cast immobilization, is still the mainstay of management.
- Trial name
- NCT01101607
- Testing
- Distal Forearm Fracture Reduction
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- InMotion Orthopaedic Research Center
Hip Arthropathy, Orthopedic Disorder
Revision LR Femoral Stem for Hip Replacement
This is a post-market, monocentric Retrospective and prospective, observational, open-label and baseline clinical study in order to evaluate the performance and safety of Revision LR femoral stem
- Trial name
- NCT05810584
- Testing
- Revision LR femoral stem
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Limacorporate S.p.a
Orthopedic Surgery, Fracture Related Infection
Comparison of Debridement, Antibiotic, Implant Retention and Implant Exchange in Early-stage Fracture-related Infections
This study aims to compare the clinical outcomes of debridement, antibiotics, and implant retention (DAIR) and implant removal/replacement methods used in the treatment of fracture-related infections, and to determine the…
- Conditions
- Orthopedic Surgery, Fracture Related Infection, Debridement, Implant Retention
- Trial name
- DAIR (NCT07669714)
- Testing
- DAIR, Implant removal/replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Antalya Health Sciences University
Constipation, Perioperative Nursing
Effect of a Constipation Prevention Checklist in Hip Surgery Patients
Constipation is a common postoperative problem in patients undergoing hip surgery and may be associated with immobilization, opioid analgesic use, and inadequate fluid and fiber intake.
- Conditions
- Constipation, Perioperative Nursing, Checklist, Orthopedic Disorder
- Trial name
- NCT07895316
- Testing
- Constipation prevention and checklist monitoring in hip surgery patients
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Wounds and Injuries
Impact of V.A.C. Veraflo Therapy in Wounds Requiring Debridement Within an Orthopedic Practice
The objective to this study is to determine the effectiveness of V.A.C.Veraflo negative pressure wound therapy with instillation, when compared to historical controls of V.A.C Therapy without instillation in the management of…
- Trial name
- NCT02266771
- Testing
- NPWT with Instillation, NPWT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- LifeBridge Health
Orthopedic Procedures, Pain, Postoperative
Risk Model for Severe Rebound Pain After Lower Limb Orthopedic Surgery Involving Single-Shot Sciatic Nerve Blocks
Rebound pain is a well-recognized phenomenon after the effects of a nerve block wear off. Severe rebound pain can happen after outpatient surgery, with patients often needing to come back to the hospital or use other health care…
- Conditions
- Orthopedic Procedures, Pain, Postoperative, Surgery, Nerve Block
- Trial name
- NCT05018104
- Testing
- This is not an interventional study
- Where
- Canada
- Volunteers
- 1,270 people
- Sponsor
- University of British Columbia
Tibial Fractures, Femoral Fractures
Distal Locking Using an Electromagnetic Field Guided Computer Based Real Time System for Orthopaedic Trauma Patients
Hypothesis: Utilization of the "wand" method will enhance improvements in drill placement, locking nail placement during tibia and femur fracture repairs, and offer less radiation exposure and less operative time.
- Trial name
- Sure Shot (NCT01183078)
- Testing
- free-hand, Wand technique
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Wake Forest University Health Sciences
Pain
Cyclical Sighing for Pain
This is a single-site, two-arm, parallel-group randomized clinical trial (RCT). The clinical effects of a 4-minute audio-recorded cyclical sighing intervention for orthopedic patients will be investigated relative to a 4-minute…
- Trial name
- NCT06292793
- Testing
- Pain Coping Information, Cyclical Sighing
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Florida State University
Diabetic Neuropathy
Plantar Pressure and Acceptance of the LEEF-shoe in Individuals With Diabetes-related Neuropathy
Rationale: Of all individuals with diabetes, 19-34% develop a foot ulcer in their lifetime, and nearly 25% of these ulcers result in amputation. Ulcer prevention is often addressed by prescribing orthopedic shoes (OS).
- Trial name
- LEEF-shoe (NCT07488104)
- Testing
- LEEF-shoe, standard orthopaedic shoe
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Orthopaedic Surgery
Pharmacokinetic, Pharmacodynamic and Pharmacogenetic of Morphine After Surgery
The main objective of this study is to improve our knowledge on the pharmacodynamic, pharmacokinetic, and pharmacogenetic relationships of morphine administered to relief severe postoperative pain.
- Trial name
- NCT00822549
- Testing
- intravenous morphine titration
- Where
- France
- Volunteers
- 438 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypothermia
Comparison of Forced Air and Conductive Patient Heating Systems During Ambulatory Surgeries
Comparison of forced air and conductive warming devices in outpatient orthopaedic surgeries.
- Trial name
- NCT02467777
- Testing
- Bair Hugger, VitaHeat
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fox Valley Orthopedic Institute
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cerebral Palsy
Effects of Walking Analysis on Surgical Outcomes
The purpose of this study is to evaluate the effects of pre-operative gait analysis testing on surgical outcomes in children with cerebral palsy who have problems walking.
- Trial name
- NCT00114075
- Testing
- Surgery with gait analysis report, Surgery without gait analysis report
- Where
- 2 sites in United States
- Volunteers
- 186 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Orthopedic Disorder
Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation
The purpose of this study is to compare the sedation efficacy of dexmedetomidine and remimazolam for intraoperative sedation during regional block.
- Trial name
- NCT05447507
- Testing
- Remimazolam, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Walking Cast Right Leg Immobilisation Effects, Aircast Right Leg Immobilisation Effects
The Effects of Lower Right Limb Orthopedic Immobilization on Driving Performance
Abstract Background: Effects of orthopedic immobilizations of the lower right limb on driving performances are unknown. Therefore, clinicians and legislators cannot put forth recommendations for road safety for patients requiring…
- Trial name
- NCT00950729
- Testing
- Driving with running shoes, Plaster cast, Driving with Aircast
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Orthopaedic Trauma, Chronic Pain
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
The purpose of this single-arm trial is to determine the feasibility of emotional awareness and expression therapy (EAET) for individuals with persistent pain following orthopedic trauma.
- Conditions
- Orthopaedic Trauma, Chronic Pain, Musculoskeletal Injury
- Trial name
- NCT05989230
- Testing
- Emotional Awareness and Expression Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Pain, Acute, Hip Arthropathy
Safety of Ibuprofen After Major Orthopaedic Surgeries
Safety of an eight-day treatment with ibuprofen after primary hip and knee arthroplasties.
- Conditions
- Pain, Acute, Hip Arthropathy, Knee Arthropathy, Safety Issues
- Trial name
- PERISAFE (NCT05575700)
- Testing
- Ibuprofen
- Where
- 11 sites in Denmark
- Volunteers
- 2,904 people
- Sponsor
- Naestved Hospital
Necrosis of Femoral Head, Knee Osteoarthritis
Ketamine Prevent POCD
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent.
- Trial name
- KPPOCD (NCT02220400)
- Testing
- Ketamine
- Where
- 3 sites in China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Knee Total Joint Replacement, Hip Total Joint Replacement
Increasing Awareness of Opioid Disposal in the Orthopedic Patient Population
Researchers are trying to determine if providing education on proper disposal of unused opioid medications to the orthopedic patient undergoing a planned hip or knee total joint replacement will increase the percentage of…
- Trial name
- NCT03954964
- Testing
- Education on disposal of opioids
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Nonunion Fracture, Delayed Bone Healing
Using the Boneflo System During Orthopedic and Trauma Surgery: A Prospective Multicenter Study
Critical bone defects, non-unions, and delayed bone healing remain major challenges in orthopedic and trauma surgery and often require bone grafting.
- Conditions
- Nonunion Fracture, Delayed Bone Healing, Critical Bone Defects
- Trial name
- BoneFlo (NCT07562165)
- Testing
- Intraoperative bioactivation of bone substitute materials using the Boneflo® Tissue Collector System.
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universität Duisburg-Essen
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