Clinical trials: Orthopedics
Pertrochanteric Fracture
Effects of a Surgical Site Injection on Pain Scores and Narcotic Use After Orthopaedic Trauma Surgery
This is a phase I, randomized, single-blind, placebo-controlled, single-center study of the effects of surgical site injection on pain and narcotic utilization in participants who undergo surgery for lower extremity fractures.
- Trial name
- NCT03693404
- Testing
- Marcaine, Duramorph , ketorolac, Bupivacaine (Marcaine), General Anesthetics
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- NYU Langone Health
Lower Limb Surgery
Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery
The purpose of this study is to compare the effects of two intrathecally administered drugs:0.5% levobupivacaine and0.75%Ropivacaine in spinal anesthesia
- Trial name
- NCT02201784
- Testing
- Levobupivacaine, Ropivacaine
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Aligarh Muslim University
Opioid Use
Life Care Specialists (LCS) With a Focus on Patient Pain Management and Prevention of Substance Misuse
The overall hypothesis of this randomized-controlled trial is that the introduction of a Life Care Specialist (LCS) as a novel member of the clinical care team will help reduce opioid utilization, decrease pain scores, and…
- Trial name
- NCT04154384
- Testing
- Life Care Specialist (LCS) Intervention, Clinical Coordination with Referrals, Pilot Study of Pain Management Strategies
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- Emory University
Venous Thromboembolism, Pulmonary Embolism
A Different Approach to Preventing Thrombosis
The purpose of this study is to perform a pragmatic randomized controlled trial to compare the use of low molecular weight heparin (LMWH, lovenox, enoxaparin) versus acetylsalicylic acid (ASA) for venous thromboembolism (VTE)…
- Trial name
- ADAPT (NCT02774265)
- Testing
- VTE prophylaxis with Enoxaparin 30mg BID, VTE prophylaxis with Aspirin 81mg BID
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- University of Maryland, Baltimore
Hemophilia A
Phase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus Intermittent Bolus Infusion in Hemophilia A Subjects Undergoing Major Orthopedic Surgery
The purpose of this study is to compare the hemostatic efficacy and safety of continuous infusion versus intermittent bolus infusion in the peri- and post-operative setting, employing rAHF-PFM, a recombinant antihemophilic factor…
- Trial name
- NCT00357656
- Testing
- Recombinant Protein-Free Factor VIII (rAHF-PFM)
- Where
- 36 sites in United States, Austria and 12 more
- Volunteers
- 85 people
- Sponsor
- Baxalta now part of Shire
Postoperative Pain
Efficacy and Safety of IV Diclofenac (DIV075V)for Pain After Elective Orthopedic Surgery
This study will compare repeated intermittent IV dosing of diclofenac in patient with moderate to severe post-surgical pain from elective orthopedic surgery.
- Trial name
- NCT00507026
- Testing
- IV Diclofenac, IV ketorolac
- Where
- 8 sites in United States
- Volunteers
- 277 people
- Sponsor
- Pfizer
Orthopedic Surgery of Lower Extremity
Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
A nerve block catheter is a small tube placed next to a nerve through a needle, and the needle is then removed. Numbing medicine is dripped through the tube to reduce pain sensation from the nerve.
- Trial name
- NCT01167907
- Testing
- 0.2% ropivacaine, saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Osteonecrosis of the Femoral Head
Study on Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral Head
Non-traumatic osteonecrosis is a painful disorder of the hip characterized by a necrosis of the osteomedullary tissue, which leads to subchondral bone collapse and joint destruction.
- Trial name
- NCT01529008
- Testing
- Core decompression/PREOB® implantation
- Volunteers
- 68 people
- Sponsor
- Bone Therapeutics S.A
Long Bone Delayed-Union Fracture
Phase 1/2a Study on Allogeneic Osteoblastic Cells Implantation in Delayed-Union Fractures
Fracture healing is a complex physiological process caused by interaction of cellular elements, cytokines and signaling proteins, which results in the formation of new bone.
- Trial name
- NCT02020590
- Testing
- ALLOB® implantation
- Volunteers
- 25 people
- Sponsor
- Bone Therapeutics S.A
Tenosynovitis
Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone
The clinical trial is a randomized control trial to compare the efficacy of a combined lidocaine and corticosteroid (CS) injection versus a corticosteroid injection (CS) alone on pain, range of motion, and patient reported…
- Trial name
- NCT03704584
- Testing
- Treatment Group: Corticosteroid injection, Control Group (corticosteroid alone), Treatment Group: Lidocaine
- Where
- 3 sites in United States
- Volunteers
- 62 people
- Sponsor
- Emory University
Venous Thromboembolism, Deep Vein Thrombosis
Weight-Based Enoxaparin Dosing and Real-Time Dose Adjustment in Orthopaedic Trauma
The rates of Venous thromboembolism (VTE) after orthopedic surgery are as high as 40-60% without prophylactic measures. Enoxaparin, a low-molecular-weight heparin, produces an anticoagulant effect by binding antithrombin, thereby…
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolus
- Trial name
- NCT03339349
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Pain
Efficacy and Safety Study of Caldolor (IV Ibuprofen) in Hospitalized Adult Orthopedic Patients
The primary objective of this study of Caldolor (IV ibuprofen) administered to post-operative hospitalized adult orthopedic patients every 6 hours for at least 24 hours is to determine the efficacy of Caldolor (IV ibuprofen)…
- Trial name
- NCT00470600
- Testing
- Caldolor, Normal Saline
- Where
- 9 sites in United States, South Africa
- Volunteers
- 185 people
- Sponsor
- Cumberland Pharmaceuticals
Older Adults, Anxiety
Behavioral Activation and Medication Optimization for Perioperative Mental Health Feasibility Study
Inadequate management of preoperative mental health disorders often contributes to poor postoperative outcomes, including increased rates of readmission, delirium, falls, and mortality.
- Conditions
- Older Adults, Anxiety, Depression, Cardiac Surgery
- Trial name
- NCT05110690
- Testing
- Behavioral Activation, Medication Optimization
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Washington University School of Medicine
Surgery, Anesthesia
Endotracheal Tube Holder and Bite Guard Research
This study aims to test the effectiveness of a novel combined endotracheal tube holder and bite guard when compared with the current standard of care, tape and an oral airway.
- Trial name
- NCT02347488
- Testing
- Haider ETT Tube Holder and Bite Guard, Tape
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Injury as a Result of Positioning
Prospective Evaluation of Cognitive Outcomes After Anesthesia on Patients in the Beach Chair Position
The purpose of this study was to use Near Infrared Spectroscopy (NIRS) monitoring on participants undergoing shoulder surgery in the beach chair position (BCP) to determine cerebral desaturation events (CDE) and to further…
- Trial name
- BCP (NCT02674334)
- Testing
- NIRS, NIRS monitored not treated
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- West Virginia University
Bone Sarcoma, Femur Fracture
Dalteparin in Preventing DVT in Participants With Cancer
This trial studies how well dalteparin works in preventing deep vein thrombosis (DVT) (blood clots) in participants with cancer. Dalteparin is a blood thinner that can treat blood clots and may prevent them from forming.
- Conditions
- Bone Sarcoma, Femur Fracture, Lymphoma, Metastatic Neoplasm
- Trial name
- NCT00525057
- Testing
- Dalteparin
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
Hand Injuries, Wrist Injuries
Study of A Long Lasting Local Anesthestic for Hand, Wrist or Finger Surgery
The purpose of this study is to compare Exparel, a new, long-lasting numbing medication and a shorter-acting nerve block to a traditional single-shot nerve block in patients having hand, wrist or finger surgery.
- Conditions
- Hand Injuries, Wrist Injuries, Finger Injuries
- Trial name
- NCT02058303
- Testing
- Exparel Forearm block, Bupivacaine supraclavicular block
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Pain
Assessing the Efficacy of IV Ibuprofen for Treatment of Pain in Orthopedic Trauma Patients
STUDY OBJECTIVES: 1. To evaluate the effectiveness of around the clock (OTC) IV ibuprofen (8 doses) in decreasing pain in orthopedic trauma patients with fractures of the extremities, face, pelvis and/or ribs compared to patients…
- Trial name
- NCT02152163
- Testing
- IV Ibuprofen
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Delray Medical Center
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated
Total Knee Arthroplasty
Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty
One postoperative complication following unilateral or bilateral total knee arthroplasty is thrombosis (blood clot formation). In this prospective, double-blinded randomized controlled clinical trial, researchers are…
- Trial name
- NCT01815918
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York