Clinical trials: Orthopedics
Adolescent Idiopathic Scoliosis
Orthopaedic Manipulation in Treatment of Adolescent Idiopathic Scoliosis
To examine the clinical efficacy of the Orthopaedic Manipulation Techniques of the Lin School of Lingnan Region in the treatment of Adolescent Idiopathic Scoliosis
- Trial name
- NCT05639023
- Testing
- Manipulation Techniques, Physiotherapy Scoliosis-Specific Exercise
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Cognitive Impairment, Mild
Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With MCI
According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups.
- Trial name
- MCI (NCT03165396)
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Third Central Clinical College of Tianjin Medical University
Hand Fractures
Mirror Therapy and Hand Rehabilitation
Objective: The purpose of this study is to determine effects of mirror therapy in restoring hand function in patients with flexor lag following orthopedic injuries.
- Trial name
- NCT01503762
- Testing
- Mirror therapy, Classical rehabilitation techniques
- Where
- Iran
- Volunteers
- 23 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Foot
Validation of the American Orthopedic Foot and Ankle Society Midfoot Scale
Today, one of the frequently used scales in the evaluation of foot problems is the American Orthopedic Foot and Ankle Association Scale.
- Trial name
- NCT05246488
- Testing
- American Orthopedic Foot and Ankle Association Midfoot Scale, Foot and Ankle Ability Measure/FAAM, SF-12 Quality of Life Scale, Visual Analog Scale (VAS)
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- University of Beykent
Femoral Neck Fractures, Intertrochanteric Fractures
Opioid-Free Pain Treatment in Trauma Patients
Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.
- Conditions
- Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture
- Trial name
- NCT06078371
- Testing
- Opioid-free pain treatment
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Muscle Atrophy, Postoperative Pain
Post-surgery Muscle Preservation and Pain Reduction Through Blood Flow Restriction Training in Orthopedic Spinal Surgery
This project investigates the effects of the Blood-Flow-Restriction (BFR) training method on postoperative muscle atrophy and pain after spinal surgery. Two groups are formed for this purpose.
- Conditions
- Muscle Atrophy, Postoperative Pain, Spondylolisthesis, Spondylodiskitis
- Trial name
- NCT06962683
- Testing
- Blood-Flow-Restriction Training
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Orthopaedic Trauma
Outcomes for Robotics in Orthopaedic Trauma
Our project aims to integrate whether robotic assistance of reduction and fixation in orthopaedic trauma surgery can enhance accuracy and surgical outcomes.
- Trial name
- NCT07732803
- Testing
- Robotic Assistance: The robotic system (R-Universal® Intelligent Robotic Surgical Systems, Beijing Rossum Robot Technology Co., Ltd.)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Venous Thromboembolism
Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs
To assess the safety and pharmacokinetics of DU-176b administered to patients with severe renal impairment undergoing orthopedic surgery of the lower limbs, compared with DU-176b administered to patients with mild renal…
- Trial name
- NCT01857583
- Testing
- 15mg DU-176b, 30mg DU-176b, Fondaparinux
- Where
- Japan
- Volunteers
- 80 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Procedural Sedation, Regional Anesthesia Block
Lusedra (Fospropofol Disodium) for Minimal to Moderate Sedation for Regional Anesthesia Block Prior to Orthopedic Surgery
How does Lusedra compare with current standard of care (midazolam) for minimal to moderate sedation for regional anesthesia blocks prior to orthopedic surgery?
- Conditions
- Procedural Sedation, Regional Anesthesia Block, Orthopedic Surgery
- Trial name
- NCT01195103
- Testing
- Fospropofol disodium, Fentanyl
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Primary Body Region (Arranged Most Common to Least), Lumbar/SI
ATI Evidence-based Guide Investigating Clinical Services
The goal of this study is to evaluate how standard-of-care outpatient rehabilitation is delivered and how variation in care delivery mechanisms relates to clinical outcomes, service utilization, and value in patients receiving…
- Conditions
- Primary Body Region (Arranged Most Common to Least), Lumbar/SI, Knee, Shoulder
- Trial name
- AEGIS (NCT02285868)
- Where
- United States
- Volunteers
- 4,000,000 people, healthy volunteers welcome
- Sponsor
- ATI Holdings, LLC
Femur Fracture, Periprosthetic Fracture of Hip
Dose-Response Association Between Cerclage Wire Number and Infection Risk
The purpose of this dual-center retrospective study is to investigate the relationship between the number of metallic cerclage wires used in femoral fracture surgery and the risk of developing deep infections.
- Conditions
- Femur Fracture, Periprosthetic Fracture of Hip, Periprosthetic Fracture of the Femur, Surgical Site Infection (SSI)
- Trial name
- C-INFECT (NCT07434258)
- Testing
- 1 Metallic Cerclage Wiring, 2 metalic cerclage wire, 3 metalic cerclage wire
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Acute Postoperative Pain, Bunionectomy
Evaluate the Efficacy and Safety of ACP-044 for the Treatment of Acute Postoperative Pain Following Bunionectomy
To evaluate the efficacy of ACP-044 compared with placebo in the treatment of acute postoperative pain
- Trial name
- NCT04855240
- Testing
- ACP-044 Dose A, ACP-044 Dose B
- Where
- 4 sites in United States
- Volunteers
- 239 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Educational Problems, Covid19
The Influence and Effects of the COVID-19 Pandemic on Orthopaedic Resident Training
Orthopedic residents, like all other healthcare professionals, face unique challenges during the coronavirus disease 2019 (COVID-19). The rapid spread of COVID-19 has forced healthcare systems around the world to adapt.
- Conditions
- Educational Problems, Covid19, Burnout, Student, Depression
- Trial name
- NCT04967768
- Testing
- Questionnaire about impact of the COVID-19 pandemic on orthopaedic resident training
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Sleep Disturbance, Trauma
Treatment for Sleep Disturbance in Orthopaedic Trauma Patients
The purpose of the study is to test the efficacy of sleep treatment in human patients following traumatic injury. Specifically, the study will determine if treatment consisting of melatonin and education related to sleep habits…
- Trial name
- NCT03779243
- Testing
- Melatonin 5mg and Sleep Education
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Anemia, Blood Transfusion
A Study of the Safety and Effectiveness of Epoetin Alfa in Facilitating Self-donation of Blood Before Surgery in Patients Who Are Undergoing Orthopedic Surgery and Who Have Low Hematocrit Levels (the Percent of Red Blood Cells in Whole Blood)
The purpose of this study is to evaluate the safety and effectiveness of epoetin alfa and to determine whether epoetin alfa will facilitate self-donation of blood before surgery in patients who have anemia, (as indicated by low…
- Conditions
- Anemia, Blood Transfusion, Orthopedic Procedures
- Trial name
- NCT00270114
- Testing
- epoetin alfa
- Volunteers
- 55 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Orthopedic Surgery
Biofilm Formation and Antibiotic Sensitivity Patterns
Detection of bacteria that form biofilm and its sensitivity to antibiotics in patients with surgical site infection after orthopedic surgery.
- Trial name
- NCT05181163
- Testing
- swab
- Volunteers
- 100 people
- Sponsor
- Sohag University
Surgical Site Infection
Nasal Decolonization for Orthopedic Trauma Patients
Many surgical site infections are caused by bacteria that is transferred from a patient's nose to their open surgical wound. Some small studies have shown that putting povidone-iodine in a patient's nose reduces this risk.
- Trial name
- NCT04146116
- Testing
- intranasal povidone-iodine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Iowa
Knee Total Joint Replacement, Hip Total Joint Replacement
Increasing Awareness of Opioid Disposal in the Orthopedic Patient Population
Researchers are trying to determine if providing education on proper disposal of unused opioid medications to the orthopedic patient undergoing a planned hip or knee total joint replacement will increase the percentage of…
- Trial name
- NCT03954964
- Testing
- Education on disposal of opioids
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Disability or Chronic Disease Leading to Disablement
Effect of Lower Extremity Traction on the Popliteal Angle After Percutaneous Needle Tenotomy of the Knee Flexor Muscles.
People with neuromotor disability (i.e. following an inborn or acquired spinal cord, cerebral or peripheral neurological lesion) are at risk of neuro-orthopaedic disorders.
- Trial name
- NCT05736328
- Testing
- Traction
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut de Sante Parasport Connecte Synergies
Environment, Waste Output
USE LESS, a Comparative Cohort Study of Climate Change Impact From Orthopedic Surgery
A prospective comparative cohort study with the objective to quantify and compare carbon dioxide equivalent (CO₂e) emissions from orthopedic surgeries performed in two different operating room (OR) settings using different sets…
- Trial name
- USELESS (NCT07657039)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet